Results 131 to 140 of about 14,957,077 (381)

Autologous BCMA/TACI-targeted CAR T Cells AUTO2 [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Retractions in Rheumatology: Trends, Causes, and Implications for Research Integrity

Arthritis Care &Research, EarlyView.
Objective We aimed to describe the trends and main reasons for study retraction in rheumatology literature. Methods We reviewed the Retraction Watch database to identify retracted articles in rheumatology. We recorded the main study characteristics, authors’ countries, reasons for retraction, time from publication to retraction, and trends over time ...
Anna Maria Vettori, Michele Iudici
wiley   +1 more source

CAR T therapies in multiple myeloma: unleashing the future

Cancer Gene Therapy
In recent years, the field of cancer treatment has witnessed remarkable breakthroughs that have revolutionized the landscape of care for cancer patients.
Mohsen Sheykhhasan, Amirhossein Ahmadieh-Yazdi, Rosario Vicidomini, Naresh Poondla, Hamid Tanzadehpanah, Ashkan Dirbaziyan, Hanie Mahaki, Hamed Manoochehri, N. Kalhor, Paola Dama   +9 more
semanticscholar   +1 more source

Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors. [PDF]

, 2019
In 2017, the US Food and Drug Administration approved the first two novel cellular immunotherapies using synthetic, engineered receptors known as chimeric antigen receptors (CARs), tisagenlecleucel (Kymriah) and axicabtagene ciloleucel (Yescarta ...
Baybutt, Trevor R., Caparosa, Ellen M., Flickinger, John C., Snook, Adam E.   +3 more
core   +1 more source

Trace Nickel Activated Biphasic Core‐CuOii/Shell‐CuOi Secondary Microspheres Enable Room Temperature Parts‐Per‐Trillion‐Level NO2 Detection

Advanced Engineering Materials, EarlyView.
An idea of designing novel sensors is proposed by creating appropriate Schottky barriers and vacancies between isomorphous Core‐CuOii/ Shell‐CuOi secondary microspheres and enhancing catalytic and spill‐over effects, and electronegativity via spontaneous biphasic separation, self‐assembly, and trace‐Ni‐doping.
Bala Ismail Adamu, Peipei Chen, Shafia Mukhtar Ibrahim, Mukhtar Lawan Adam, Attia Falak, Mokhotjwa Simon Dhlamini, Hanfu Wang, Lingxiang Jiang, Weiguo Chu   +8 more
wiley   +1 more source

c-Jun overexpression in CAR T cells induces exhaustion resistance

Nature, 2019
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1–3, but dysfunction due to T cell exhaustion is an important barrier to progress4–6.
Rachel C. Lynn, Evan W. Weber, E. Sotillo, David G Gennert, P. Xu, Zinaida Good, H. Anbunathan, John Lattin, Robert B. Jones, Victor Tieu, S. Nagaraja, Jeffrey M. Granja, Charles DeBourcy, R. Majzner, Ansuman T. Satpathy, S. Quake, Michelle Monje, Howard Y. Chang, C. Mackall   +18 more
semanticscholar   +1 more source

Application of CAR-T cells in cancer gene therapy [PDF]

, 2018
Genska terapija predstavlja obećavajući terapijski alat za liječenje onih bolesti koje se konvencionalnim metodama liječenja nisu uspješno uspijele eliminirati.
Krmpotić, Klara
core   +2 more sources

Interaction between Molten Al‐Killed Mn–B Steel and Carbon‐Bonded MgO Refractories Based on Recyclates

Advanced Engineering Materials, EarlyView.
High‐temperature interactions between low‐sulfur Al‐killed Mn–B steel and MgO–C refractories (0 and 50 wt% recyclates) are studied via finger immersion tests (1600 °C). Surface‐active elements influence infiltration. MgO/CaS layer forms, along with spinel and calcium silicate.
Matheus Roberto Bellé, Lukas Neubert, Anton Yehorov, Till M. J. Stadtmüller, Christos G. Aneziris, Olena Volkova   +5 more
wiley   +1 more source

CAR‐Aptamers Enable Traceless Enrichment and Monitoring of CAR‐Positive Cells and Overcome Tumor Immune Escape

Advanced Science
Chimeric antigen receptor (CAR)‐positive cell therapy, specifically with anti‐CD19 CAR‐T (CAR19‐T) cells, achieves a high complete response during tumor treatment for hematological malignancies. Large‐scale production and application of CAR‐T therapy can
Hang Zhou, Tuersunayi Abudureheman, Wei‐Wei Zheng, Li‐Ting Yang, Jian‐Min Zhu, Ai‐Bin Liang, Cai‐Wen Duan, Kaiming Chen   +7 more
doaj   +1 more source

Tumor Antigen Escape from CAR T-cell Therapy.

Cancer Discovery, 2018
Emerging data from chimeric antigen receptor (CAR) T-cell trials in B-cell malignancies demonstrate that a common mechanism of resistance to this novel class of therapeutics is the emergence of tumors with loss or downregulation of the target antigen ...
R. Majzner, C. Mackall
semanticscholar   +1 more source