Results 151 to 160 of about 14,957,077 (381)

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Progress and Prospects of CAR-T Therapy for the Treatment of Solid Tumors

, 2023
Yuhan Zeng
openalex   +2 more sources

How I Treat Refractory CRS and ICANS Following CAR T-cell Therapy [PDF]

, 2023
Michael D. Jain, Melody Smith, Nirali N. Shah   +2 more
openalex   +1 more source

Composites of Shellac and Silver Nanowires as Flexible, Biobased, and Corrosion‐Resistant Transparent Conductive Electrodes

Advanced Functional Materials, EarlyView.
Shellac, a centuries‐old natural resin, is reimagined as a green material for flexible electronics. When combined with silver nanowires, shellac films deliver transparency, conductivity, and stability against humidity. These results position shellac as a sustainable alternative to synthetic polymers for transparent conductors in next‐generation ...
Rahaf Nafez Hussein, Tiago Carneiro Gomes, Eliza Ng, Simon Rondeau‐Gagné, Tricia Breen Carmichael   +4 more
wiley   +1 more source

Senolytic CAR T cells [PDF]

Nature Medicine, 2020
openaire   +2 more sources

Placental circulating T cells: a novel, allogeneic CAR-T cell platform with preserved T-cell stemness, more favorable cytokine profile, and durable efficacy compared to adult PBMC-derived CAR-T

Journal for ImmunoTherapy of Cancer
Background Chimeric antigen receptor (CAR)-T cell quality and stemness are associated with responsiveness, durability, and memory formation, which benefit clinical responses. Autologous T cell starting material across patients with cancer is variable and
Robert Hariri, Shuyang He, William van der Touw, Kathy Karasiewicz, Natalia Ruggeri Barbaro, Theodore Drashansky, Kristina Tess, Mansour Djedaini   +7 more
doaj   +1 more source

CD19/CD22 bispecific CAR-T cells for MRD-positive adult B cell acute lymphoblastic leukemia: a phase I clinical study [PDF]

, 2023
Jiahua Niu, Huiying Qiu, Xiang Fang, Lin Zhu, Jun J. Yang, Chongmei Huang, Kun Zhou, Tong Yin, Yu Cai, Baoxia Dong, Yuan Lu, Xuedong Sun, Liping Wan, Xueying Ding, Haopeng Wang, Xianmin Song   +15 more
openalex   +1 more source

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Nature
Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and multiple myeloma1–4, but the efficacy of CAR T cell therapy in solid tumours has been ...
Jack D. Chan, Christina M Scheffler, Isabelle Munoz, K. Sek, Joel N Lee, Yu-Kuan Huang, Kah Min Yap, Nicole Y. L. Saw, Jasmine Li, Amanda X. Y. Chen, Cheok Weng Chan, Emily B Derrick, Kirsten L Todd, Junming Tong, Phoebe A Dunbar, Jiawen Li, Thang X Hoang, Maria N. de Menezes, Emma V. Petley, Joelle S Kim, DatMinh Nguyen, Patrick S K Leung, Joan So, C. Deguit, J. Zhu, Imran G. House, Lev M. Kats, Andrew M Scott, Benjamin J. Solomon, Simon J. Harrison, J. Oliaro, I. Parish, Kylie M. Quinn, P. Neeson, C. Slaney, Junyun Lai, P. Beavis, P. Darcy   +37 more
semanticscholar   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Data from Tuning the Antigen Density Requirement for CAR T-cell Activity

, 2023
Robbie G. Majzner, Skyler P. Rietberg, Elena Sotillo, Rui Dong, Vipul T. Vachharajani, Louai Labanieh, June H. Myklebust, Meena Kadapakkam, Evan W. Weber, Aidan M. Tousley, Rebecca M. Richards, Sabine Heitzeneder, Sang M. Nguyen, Volker Wiebking, Johanna Theruvath, Rachel C. Lynn, Peng Xu, Alexander R. Dunn, Ronald D. Vale, Crystal L. Mackall   +19 more
openalex   +1 more source