Results 161 to 170 of about 14,957,077 (381)

CAR T cell immunotherapy for human cancer

Science, 2018
C. June, Roddy S. O’Connor, O. Kawalekar, S. Ghassemi, M. Milone   +4 more
semanticscholar   +1 more source

FOXO1 is a master regulator of memory programming in CAR T cells

Nature
A major limitation of chimeric antigen receptor (CAR) T cell therapies is the poor persistence of these cells in vivo1. The expression of memory-associated genes in CAR T cells is linked to their long-term persistence in patients and clinical efficacy2–6,
Alexander E Doan, Katherine P Mueller, Andy Y. Chen, Geoffrey T. Rouin, Yingshi Chen, Bence Daniel, John Lattin, M. Markovska, Brett Mozarsky, Jose Arias-Umana, Robert Hapke, Inyoung Jung, Alice Wang, Peng Xu, D. Klysz, Gabrielle Zuern, Malek Bashti, Patrick Quinn, Zhuang Miao, Katalin D. Sandor, Wenxi Zhang, Gregory M Chen, Faith Ryu, Meghan T. Logun, Junior Hall, Kai Tan, Stephan A. Grupp, Susan E. McClory, Caleb A. Lareau, J. Fraietta, E. Sotillo, Ansuman T. Satpathy, Crystal L. Mackall, Evan W. Weber   +33 more
semanticscholar   +1 more source

Stock market reactions to unfavorable product information: A case study of comments on beef safety made on an Oprah Winfrey Show [PDF]

, 2000
This study examines the impact of unfavorable media coverage on the stock market prices of major food companies, an issue of increasing importance to the food industry.
Ormanidou, Elpida, Thomsen, Michael
core   +2 more sources

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

Supplementary Figure from Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors [PDF]

, 2023
Alexandra Martin, Carmen M. Anadon, Subir Biswas, Jessica A. Mine, Katelyn F. Handley, Kyle K. Payne, Gunjan Mandal, Ricardo A. Chaurio, John J. Powers, Kimberly B. Sprenger, Kristen E. Rigolizzo, Patrick Innamarato, Carly M. Harro, Sumit Mehta, Bradford A. Perez, Robert M. Wenham, José R. Conejo-García   +16 more
openalex   +1 more source

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Science Translational Medicine, 2014
M. Davila, I. Rivière, Xiuyan Wang, S. Bartido, Jae H. Park, K. Curran, S. Chung, J. Stefanski, Oriana Bórquez-Ojeda, M. Olszewska, Jinrong Qu, Teresa Wasielewska, Q. He, Mitsú J. Fink, Himaly Shinglot, M. Youssif, M. Satter, Yongzeng Wang, James Hosey, Hilda Quintanilla, E. Halton, Y. Bernal, Diana C. G. Bouhassira, M. Arcila, M. Gonen, G. Roboz, P. Maslak, D. Douer, M. Frattini, S. Giralt, M. Sadelain, R. Brentjens   +31 more
semanticscholar   +1 more source

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction

Nature Aging
Senescent cells, which accumulate in organisms over time, contribute to age-related tissue decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies, including metabolic dysfunction and decreased physical fitness.
Corina Amor, Inés Fernández-Maestre, Saria Chowdhury, Yu-jui Ho, Sandeep Nadella, Courtenay Graham, Sebastian E. Carrasco, Emmanuella Nnuji-John, Judith Feucht, Clemens Hinterleitner, Valentin J A Barthet, Jacob A. Boyer, Riccardo Mezzadra, Matthew Wereski, D. Tuveson, Ross L. Levine, Lee W Jones, Michel Sadelain, Scott W. Lowe   +18 more
semanticscholar   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

CAR Beyond αβ T Cells: Unleashing NK Cells, Macrophages, and γδ T Lymphocytes Against Solid Tumors

Vaccines
Chimeric antigen receptor (CAR)-engineered cell therapy represents a landmark advancement in cancer immunotherapy. While αβ CAR-T therapy has demonstrated remarkable success in hematological malignancies, its efficacy in solid tumors remains constrained ...
Yunjia Xian, Lu Wen
doaj   +1 more source

Reshaping the tumor immune microenvironment to improve CAR-T cell-based cancer immunotherapy

Molecular Cancer
In many hematologic malignancies, the adoptive transfer of chimeric antigen receptor (CAR) T cells has demonstrated notable success; nevertheless, further improvements are necessary to optimize treatment efficacy. Current CAR-T therapies are particularly
Xueting Xia, Zongxin Yang, Qisi Lu, Zhenyun Liu, Lei Wang, Jinwen Du, Yuhua Li, Dong-Hua Yang, Shaojie Wu   +8 more
semanticscholar   +1 more source