Results 71 to 80 of about 293,272 (302)

Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the Fuel. [PDF]

, 2017
T-cells play a critical role in tumor immunity. Indeed, the presence of tumor-infiltrating lymphocytes is a predictor of favorable patient prognosis for many indications and is a requirement for responsiveness to immune checkpoint blockade therapy ...
Ackerman, Ahmed, Ansell, Araki, Ascierto, Beatty, Beatty, Blagih, Borkner, Brahmer, Brandacher, Brentjens, Brentjens, Bridgeman, Brocker, Brudno, Buck, Buckanovich, Burnette, Butler, Butler, Carpenito, Caruana, Caruso, Chang, Chang, Chen, Chen, Chen, Cherkassky, Chmielewski, Church, Colegio, Cordoba, Cretenet, Crompton, Cui, Curiel, Curran, Deaglio, Demaria, Doedens, Facciabene, Fesnak, Finney, Fischer, Fousek, Fox, Frauwirth, Frauwirth, Fridman, Fuertes, Gabrilovich, Gajewski, Gajewski, Galon, Gargett, Gattinoni, Gattinoni, Gattinoni, Geiger, Geissmann, Gill, Gobert, Govers, Gracias, Grada, Gross, Gross, Gubin, Gubser, Guest, Guppy, Hall, Hamanishi, Han, Harlin, Herrera, Hinrichs, Hinrichs, Ho, Hodi, Hombach, Hombach, Hombach, Hsu, Huang, Hudecek, Hwang, Iida, Ino, Irving, Italiani, James, Jass, Jensen, Jensen, Ji, Jones, Joyce, June, Justus, Kahlon, Kawalekar, Kerkar, Kershaw, Kershaw, Khalil, Khalil, Klebanoff, Klebanoff, Klebanoff, Klug, Lamers, Lanitis, Lanitis, Larkin, Le, Le, Lee, Li, Lipson, Liu, Liu, Lochner, Long, Louis, Lugli, Lunt, MacIver, Mahoney, Martinez-Forero, Marvel, Maude, Maus, Maus, Mellor, Menetrier-Caux, Mikucki, Miller, Mittal, Moon, Morgan, Morgan, Morsut, Motz, Motz, Motzer, Muniappan, Munn, Munn, Munn, Murdoch, Nghiem, Niederman, Noman, Okamoto, Otsuji, O’Sullivan, O’Sullivan, Palazón, Palmer, Pameijer, Pandiyan, Paolino, Pardoll, Parry, Patsoukis, Pearce, Pegram, Peng, Peng, Pipkin, Pluta, Porter, Powles, Prosser, Rabinovich, Rathmell, Restifo, Rizvi, Rodriguez, Rodriguez, Rosenberg, Rosenberg, Roybal, Salerno, Sallusto, Santoro, Savoldo, Scharping, Schmid, Schwartz, Semenza, Sharpe, Sikalidis, Sinclair, Singh, Sivan, Smith, Snyder, Sommermeyer, Spranger, Spranger, Spranger, Srivastava, Stromnes, Suarez, Sukumar, Sukumar, Tamada, Tan, Taylor, Terakura, Topalian, Topalian, Topalian, Torikai, Tran, Tumeh, Turatti, Urbanska, Uyttenhove, van der Merwe, van der Waart, van der Windt, van der Windt, van der Windt, van Rooij, Vander Heiden, Vuillefroy de Silly, Vuillefroy de Silly, Vétizou, Waickman, Wang, Wang, Wang, Wang, Wang, Warburg, Wherry, Willemsen, Wing, Wofford, Wu, Xu, Yang, Yang, Yaqoob, Zhang, Zhang, Zhang, Zheng   +252 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Impact of COVID-19 and Future Emerging Viruses on Hematopoietic Cell Transplantation and Other Cellular Therapies [PDF]

, 2020
COVID-19, where Co stands for corona, VI stands for virus, and D denotes disease, in the recent past referred to as 2019 novel coronavirus or 2019-nCoV, has impacted numerous lives and businesses, and has led to a surreal emergency state within world ...
Broxmeyer, Hal E., Parker, Graham C.
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases. [PDF]

, 2018
One major hurdle to the success of adoptive T-cell therapy is the identification of antigens that permit effective targeting of tumors in the absence of toxicities to essential organs.
Abraham, Tara S., Baybutt, Trevor R., Flickinger, John C., Hersperger, Adam R., Magee, Michael S., Marszalowicz, Glen P, Prajapati, Priyanka, Ridge, Natalie A., Snook, Adam E., Waldman, Scott A.   +9 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies

Molecular Cancer, 2020
Targeting T cell receptor β-chain constant region 1 (TRBC1) CAR-T could specifically kill TRBC1+ T-cell malignancies. However, over-expressed CARs on anti-TRBC1 CAR transduced TRBC1+ T cells (CAR-C1) bound to autologous TRBC1, masking TRBC1 from ...
Chaoting Zhang, Heyilimu Palashati, Zhuona Rong, Ningjing Lin, Luyan Shen, Ying Liu, Shance Li, Bentong Yu, Wenjun Yang, Zheming Lu   +9 more
doaj   +1 more source

Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells [PDF]

, 2016
The success of adoptive T-cell therapies for the treatment of cancer patients depends on transferred T-lymphocytes finding and infiltrating cancerous tissues.
Ager, Elizabeth, Mohammed, Rebar N., Watson, Heulwen Angharad, Wehenkel, Sophie C.   +3 more
core   +2 more sources