Results 171 to 180 of about 16,333 (208)

Learned aversions to intracerebral carbachol

Physiology & Behavior, 1977
Abstract The learned taste aversion paradigm was employed to test for aversive effects of microinjections of carbachol to the medial septum, lateral ventricle and ventral hippocampus. To determine the locus of action of carbachol, either a central cholinergic blocker (atropine sulfate) or a peripheral cholinergic blocker (atropine methyl nitrate) was
Richard H. Myers, John M. de Castro
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Comparison of intraocular acetylcholine and carbachol

Journal of Cataract and Refractive Surgery, 1986
Commercially available 1% acetylcholine chloride and 0.01% carbachol chloride, which are commonly used as miotics in intraocular surgery, have recently been reformulated. Comparative studies of these agents show similar miotic activity. However, in vitro perfusion of human corneas demonstrated that 1% acetylcholine chloride causes marked changes in ...
Henry F. Edelhauser, Richard W. Yee
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Determination of Carbachol in Aqueous Solution

Journal of Pharmaceutical Sciences, 1969
A more specific method of analysis of carbachol (carbamylcholine chloride) in aqueous solution is reported. The procedure requires the chlorination of the free N—H moiety which in turn is utilized to oxidize iodide to iodine. Quantitation is then accomplished by reacting this latter product with starch and measuring the resultant blue color.
Richard D. Poe, Ramona Puckett
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Carbachol effects on hippocampal neurons in vitro: dependence on the rate of rise of carbachol tissue concentration

Experimental Brain Research, 1988
Nominally K-sensitive microelectrodes were used to measure carbachol (CCh) in order to study the dependence of muscarinic effects on CCh concentration and exposure time in guinea pig hippocampal slices. Interference presumably originating from tissue choline-compounds was neutralized by pre-equilibration of the slices with 500 microM choline and ...
Udo Heinemann, W. Müller, U. Misgeld
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Pharmacological Studies on N-Demethylated Carbachol

Journal of Pharmaceutical Sciences, 1978
In attempts to find a drug more active than pilocarpine, the tertiary nitrogen derivative of carbachol, N-demethylated carbachol, was synthetized and tested on several autonomic nervous system preparations. N-Demethylated carbachol was active at muscarinic and nicotinic sites in vivo and in vitro.
C.Y. Chiou, J. Trzeciakowski
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Central hyperglycaemic effect of adrenaline and carbachol

Acta Endocrinologica, 1985
Abstract. The effect of chemical stimulation of the brain on glucoregulation was studied in anaesthetized rats. Adrenaline, noradrenaline, acetylcholine, dopamine and carbachol (5 × 10−8 mol/μl saline) were injected directly into the third cerebral ventricle and changes in hepatic venous plasma glucose, immunoreactive glucagon and insulin ...
Akihisa Iguchi, M. Gotoh, H. Matsunaga, T. Nomura, Nobuo Sakamoto, A. Yatomi   +5 more
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IR Spectrophotometric Assay of Carbachol Solutions

Journal of Pharmaceutical Sciences, 1977
Carbachol ophthalmic solutions can be assayed by evaporating a measured volume, dissolving the residue in methanol, and scanning the carbonyl stretching frequency in an IR spectrophotometer using a cell with calcium fluoride windows. Methylcellulose and other formulation vehicle components do not interfere.
Lester Chafetz, John Frank
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Central hyperglycemic effect of carbachol in rats

European Journal of Pharmacology, 1976
Intraventricular injection of carbachol produces hyperglycemia in rats at doses which are ineffective when given subcutaneously. This effect is suppressed by intraventricular administration of small amounts of atropine, further supporting the suggestion that the effect of carbachol is due to its action on central cholinergic receptors.
Mira Korner, Avner Ramu
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Carbachol☆

2007
Carbachol is a structural analog of acetylcholine and has agonist activity at muscarinic and nicotinic cholinergic receptors. It is like acetylcholine in being a quaternary amine and having a positive charge at all pH values. A major difference from acetylcholine is that carbachol is not hydrolyzed by cholinesterases.
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Effect of Carbachol on Rabbit Corneal Endothelium

Archives of Ophthalmology, 1987
We investigated the current reformulation of the commercially available intraocular preparation of carbachol for its effect on corneal thickness and endothelial cell ultrastructure. A 15-minute perfusion in the specular microscope with 0.01% carbachol caused a significant increase in the corneal swelling rate, which returned to control values after 75 ...
David S. Hull, Keith Green, Nanalane P. Frey, David Birnbaum   +3 more
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