Resveratrol-Based Carbamates as Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, Computational Study and Biometal Complexation Capability [PDF]
MoleculesConsidering our previous experience in the design of new cholinesterase inhibitors, especially resveratrol analogs, in this research, the basic stilbene skeleton was used as a structural unit for new carbamates designed as potentially highly selective ...
Maja Sviben +8 more
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Heterostilbene Carbamates with Selective and Remarkable Butyrylcholinesterase Inhibition: Computational Study and Physico-Chemical Properties [PDF]
BiomoleculesThis manuscript reports the synthesis and characterization of 19 novel heterostilbene carbamates, designed as selective butyrylcholinesterase (BChE) inhibitors with potential applications in the treatment of neurodegenerative disorders, particularly ...
Anamarija Raspudić +11 more
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Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa [PDF]
ParasiteThe spread of resistance to insecticides, such as pyrethroids, in Aedes vectors increases the risk of spread of arboviral diseases. In Gabon, the insecticide resistance profiles of Ae. aegypti and Ae. albopictus species remain poorly known.
Obame-Nkoghe Judicaël +14 more
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Molecules, 2021 Neurological and neurodegenerative diseases are debilitating conditions, and frequently lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of 2-AG (2-arachidonoylglycerol), a neuroprotective ...
Anca Zanfirescu +4 more
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Modeling of Isocyanate Synthesis by the Thermal Decomposition of Carbamates
Computation, 2020 The presented work is devoted to isocyanate synthesis by the thermal decomposition of carbamates model. The work describes the existing isocyanate-obtaining processes and the main problems in the study of isocyanate synthesis by the thermal decomposition
Ratmir Dashkin +7 more
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Benzyl Carbamates of 4-Aminosalicylanilides as Possible BACE1 Modulators
Chemistry Proceedings, 2022 Recently, a series of thirty-eight 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides designed as potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors were described as potential drugs to alleviate the symptoms of Alzheimer’s ...
Petra Majerova +6 more
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Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates
Molecules, 2020 Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1).
Anita Bosak +5 more
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QSTR Modeling to Find Relevant DFT Descriptors Related to the Toxicity of Carbamates
Molecules, 2022 Compounds containing carbamate moieties and their derivatives can generate serious public health threats and environmental problems due their high potential toxicity.
Emma H. Acosta-Jiménez +8 more
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Potential revival of cholinesterase inhibitors as drugs in veterinary medicine
Frontiers in Veterinary Science, 2023 The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes
Neža Žnidaršič +3 more
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Heliyon, 2019 Carbamates are synthetic pesticides, extensively used throughout the world due to their broad specificity against various insect pests. However, their enormous and inadequate use have made them a potential threat to the environment.
Anum Fareed +8 more
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