Results 221 to 230 of about 18,824 (297)

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Identification of Urethanases for Biocatalytic Recycling of Toluene Diisocyanate- and Methylene Diphenyl Diisocyanate-Based Polyurethanes. [PDF]

ChemSusChem
Pastor L, Schell K, Göbbels S, Contreras F, Bienstein M, Jäger G, Schwaneberg U, Reisky L.   +7 more
europepmc   +1 more source

(Talanta, 63(3):547-553)Simultaneous determination of airborne carbamates in workplace by high performance liquid chromatography with fluorescence detection

, 2014
Jen-Fon Jen, Hong-Ping Li, Gwo-Chen Li
core  

Click to Translate: Synthesis of Trans‐Cyclooctene Modified 5′ mRNA Caps for Bioorthogonal Activation

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Trans‐cyclooctene‐modified 5′‐Cap analogues provide a platform for bioorthogonal modulation of mRNA translation. A controlled synthetic strategy enabled access to functionalized Caps that attenuate translation and permit partial restoration upon tetrazine addition.
Niclas Zips, Ekaterina Kulko, Stephanie Kath‐Schorr   +2 more
wiley   +1 more source

3-Component reactions for accessing heterocycle-rich topologies: trapping of pyrrole-stabilized carbenes <i>via</i> net bimolecular C-H or N-H insertion. [PDF]

Chem Sci
Guzman AL, Toll KB, Hoye TR.
europepmc   +1 more source

Structure‐Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
We developed new derivatives of the cancer drug ponatinib, significantly reducing and altering its spectrum of target kinases. Compound 5 retained the efficacy in inhibiting the colony formation of MDA‐MB‐231 cells and acted primarily on B‐Raf and Flt‐1 as its main targets in a kinase panel.
Tobias Betzholz, Ting Liu, Andreas Krämer, Verena Dederer, Stefan Knapp, Sebastian Mathea, Christian Ducho, Matthias Engel   +7 more
wiley   +1 more source

Discovery of orally active and serine-targeting covalent inhibitors against hCES2A for ameliorating irinotecan-triggered gut toxicity. [PDF]

Acta Pharm Sin B
Zhang Y, Fan Y, Song Y, Zhu G, Li X, Huang J, Guo X, Luan C, Kang D, Chen L, Xiao Z, Guo Z, Zeng H, Chen D, Sang Z, Ge G.   +15 more
europepmc   +1 more source

Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou, Kalliopi Christopoulou, Amalia D. Kalampaliki, Aikaterini F. Giannopoulou, Eleftheria Chatziorfanou, Vivi Bafiti, Andreas Krämer, Athanasios Papakyriakou, Dimitrios J. Stravopodis, Stefan Knapp, Ioannis K. Kostakis   +10 more
wiley   +1 more source

Transformation of Linear Alkenyl <i>N</i>-Alkoxy Carbamates into Cyclic Bromo Carbonates. [PDF]

Chemistry (Basel)
Sathyamoorthi S, Kelley SP.
europepmc   +1 more source

Probing 3‐Amino‐2H‐Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A palladium‐catalyzed domino reaction facilitated the discovery and rapid synthesis of selective, potent 3‐amino‐2H‐azaindazole derivatives serving as allosteric inhibitors of SHP2. Structural analysis via co‐crystallography confirmed binding at the allosteric site, thereby stabilizing the autoinhibited SHP2 conformation, qualifying this scaffold as a ...
Machoud Amoussa, Nina‐Louisa Efrém, Feng Li, Ziqiong Guo, Yvette Roske, Katrin Jana Frank, Szymon Pach, Clemens Alexander Wolf, Feng Bo, Marina Lesina, Mika Kintzel, Rana Alsalim, Victoria Zeitz, Noémi Csorba, Silke Radetzki, György M. Keserű, Oliver Daumke, Hana Algül, Gerhard Wolber, Jia Li, Marc Nazaré   +20 more
wiley   +1 more source