Results 121 to 130 of about 120,317 (381)

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012

Journal of Research in Medical Sciences, 2013
Background: Carbamazepine has been used as AEDs since 1965, and is most effective against partial seizures. Two basic mechanisms of action have been proposed: 1) enhancement of sodium channel inactivation by reducing high-frequency repetitive firing of ...
Zahra Tolou-Ghamari, Mohammad Zare, Jafar Mehvari Habibabadi, Mohammad Reza Najafi   +3 more
doaj  

A case report: Management of carbamazepine intoxication using hemodialysis followed by continuous venovenous hemodialysis

SAGE Open Medical Case Reports
An 18-year-old woman presented to the emergency department. She had ingested 43 extended-release tablets of carbamazepine 400 mg. Although the patient had high carbamazepine plasma levels and classified as severe intoxication, her clinical symptoms were ...
Heshu Abdullah-Koolmees, Vivian CC Mekel, Agnes I Veldkamp, Martine G Caris, Eleonora L Swart   +4 more
doaj   +1 more source

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document

European Journal of Heart Failure, EarlyView.
Main categories of harmful drugs in heart failure. CCB, calcium channel blocker; DPP4i, dipeptidyl peptidase‐4 inhibitor; HER2‐TT, human epidermal growth factor receptor 2‐targeted therapy; NSAID, non‐steroidal anti‐inflammatory drug; TKI, tyrosine kinase inhibitor; TZD, thiazolidinedione; VEGF Inh, vascular endothelial growth factor inhibitor.
Amr Abdin, Johann Bauersachs, Magdy Abdelhamid, Suleman Aktaa, Hussam Al Ghorani, Antonio Bayes‐Genis, Jan Biegus, Michael Böhm, Javed Butler, Nicolas Girerd, Marco Metra, Wilfried Mullens, Hadi Skouri, Muthiah Vaduganathan, Seif El Hadidi, Giuseppe M.C. Rosano, Gianluigi Savarese   +16 more
wiley   +1 more source

Relation between serum vitamin B₁₂ level and duration of treatment with carbamazepine in epilepsy patients

Bangabandhu Sheikh Mujib Medical University Journal, 2016
Vitamin B12 levels in the serum of 58 epileptic patients receiving only carbamazepine for at least 6 months were measured. Same number of epilepsy patients with no history of taking antiepileptic medicine were taken as control.
Mohammad Tariqul Islam, Khair M. Sobhan, Mahjabin Rahman Shawly, Shafiqur Saleheen, Mohammad Masum Emran, M. A. Hannan   +5 more
doaj   +1 more source

Grape-Like Cnts/Batio3 Nanocatalyst Boosted Hydraulic-Driven Piezo-Activation of Peroxymonosulfate for Carbamazepine Removal

, 2022
Ying Zheng, Wei Zhuang, Xiaohui Zhang, Junying Xiang, Xuxu Wang, Ziheng Song, Zhiping Cao, Chun Zhao   +7 more
openalex   +1 more source

Radiofrequency thermocoagulation for the treatment of refractory focal status epilepticus

Epileptic Disorders, EarlyView.
Abstract This case study reports the first documented use of stereoelectroencephalography (SEEG)‐guided radiofrequency thermocoagulation (RFTC) to treat refractory status epilepticus (RSE). A 33‐year‐old woman with drug‐resistant epilepsy and recurrent RSE underwent SEEG to define her epileptogenic zone.
Odile Feys, Julia Makhalova, Thomas Manners, José‐David Herrera‐García, Romain Carron, Fabrice Bartolomei   +5 more
wiley   +1 more source

Unmet needs of women with epilepsy living in rural low‐ and middle‐income countries: The experience of the Bolivian Chaco

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy affects approximately 70 million people worldwide, with 80% living in low‐ and middle‐income countries (LMICs), where many people with epilepsy (PWE) go undiagnosed or untreated. Over the last few decades, many efforts have been made worldwide to reduce the treatment gap (TG) in LMICs.
Alessandra Nicoletti, Gianluca Latino, Calogero Edoardo Cicero, Anna Barbiero, Chiara Aguzzoli, Bianca Ribelli, Valentina Petrini, Maria Micieli, Sandra Padilla, Estela Vilte, Francesco Cosmi, Elizabeth Blanca Crespo Gomez, Alessandro Bartoloni, Loretta Giuliano   +13 more
wiley   +1 more source

Cilostazol geno-protective effects mitigate carbamazepine-induced genotoxicity in human cultured blood lymphocytes

Toxicology Reports
Background: Carbamazepine is one of the most widely used antiepileptic drugs. Carbamazepine has been shown to be toxic to cells. Cilostazol, an antiplatelet agent, has known antioxidant, antiproliferative, anti-inflammatory, and anti-tumor effects ...
Enaam M. Al Momany, Abeer M. Rababa’h, Karem H. Alzoubi, Omar F. Khabour   +3 more
doaj   +1 more source

Pentoxifylline ameliorates carbamazepine-induced hepatotoxicity via down expression of CYP3A4 and NF-kB gene expression in the rat: in vivo study [PDF]

Pharmacia
Drug-induced liver injury (DILI) is a serious complication of many drugs, including carbamazepine; this study investigates the protective effect of pentoxifylline (PTX) against DILI induced by carbamazepine in rat models by attenuating CYP3A4 and NF-κB ...
Farah Rafie Mohammed, Yassir Mustafa Kamal Al Mulla Hummadi, Muthanna I. Al-Ezzi   +2 more
doaj   +3 more sources