Results 151 to 160 of about 56,505 (288)

Voltage-gated sodium channel, Nav 1.8, regulates calcium dynamics in the dorsal root ganglion induced by cold nociceptive stimulus. [PDF]

PLoS One
Dey MR, Li B, Heddleston J, Aihara E.
europepmc   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Polypharmacy among adolescents and adults with cerebral palsy in a clinical setting

PM&R, EarlyView.
Abstract Background Adolescents and adults with cerebral palsy often experience multimorbidity related to their condition, which primarily affects movement and posture but is also associated with pain, epilepsy, mood disorders, and other conditions. As such, these patients are often prescribed a range of medications to manage symptoms, thereby putting ...
Caitlin Cassidy, Joshua C. Wiener, Karen Pratt, Laura Brunton   +3 more
wiley   +1 more source

Boy in the Barrel: Excruciating Paroxysmal Pain Disorder Associated With an SCN9A Gain-of-Function Variant. [PDF]

J Peripher Nerv Syst
Tomaselli PJ, Frezatti RSS, Record CJ, Schiavoni MCL, Dominik N, Vandrovcova J, Reilly MM, Marques W.   +7 more
europepmc   +1 more source

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Successful Treatment of Rapid Cycling Bipolar Disorder With Lurasidone, Clozapine, and Valproate: A Case Report. [PDF]

Bipolar Disord
Potměšil P, Kopeček M, Andrashko V.
europepmc   +1 more source

Ammonia Oxidation for Energy Conversion and Environmental Remediation: Mechanism‐Guided Catalyst Design for Electrochemical, Photocatalytic, and Photoelectrochemical Systems

Small, EarlyView.
This review establishes a mechanism‐guided framework for catalyst design in electrochemical, photocatalytic, and photoelectrochemical ammonia oxidation. By correlating catalyst structure, reaction mechanisms, catalytic performance, and device‐level architectures, it highlights rational engineering strategies and future directions toward efficient ...
Dong Hyun Heo, Won Young Song, Mi Gyoung Lee   +2 more
wiley   +1 more source

Acute catatonia and psychosis in the context of seizure exacerbation in epilepsy: a case report. [PDF]

Front Psychiatry
Alowais M, Khan Z, Salamah F, Khalil D, Murad L, Marashi S.   +5 more
europepmc   +1 more source

Photocatalytic and Biotechnological Strategies for Remediation of Persistent Organic Pollutants: Mechanisms, Toxicity, and Antimicrobial Perspectives

Environmental Toxicology, EarlyView.
ABSTRACT Persistent organic pollutants (POPs) pose significant ecological and human health risks due to their persistence, bioaccumulation, toxicity, and global distribution. Conventional remediation methods are often inadequate for achieving complete mineralization, demonstrating the need for advanced and substantial approaches.
Viola O. Okechukwu, Patrick B. Njobeh, Jonathan O. Okonkwo   +2 more
wiley   +1 more source

Application of electrostatic and multi‐layer embedding in Hirshfeld atom refinements: a cost‐effective approach for approximating bulk effects in crystalline environments

Journal of Applied Crystallography, EarlyView.
A new efficient embedding mechanism for molecule‐in‐a‐crystal electron‐density calculations during Hirshfeld atom refinement is made available in NoSpherA2 and benchmarked.One of the main advantages of Hirshfeld atom refinement (HAR), besides improved refinement statistics and reduced uncertainties of all derived parameters, is the possibility of ...
Bruno Landeros-Rivera, Florian Kleemiss
wiley   +1 more source