Results 171 to 180 of about 38,738 (216)

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug‐resistant focal epilepsy

open access: yesEpilepsia Open, Volume 11, Issue 4, Page 1171-1183, August 2026.
Abstract Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB treatment.
Silvano R. Gefferie   +7 more
wiley   +1 more source

Progressive myoclonus epilepsy in Down syndrome with Alzheimer's disease: An 11‐year longitudinal study and proposed diagnostic red flags

open access: yesEpilepsia Open, Volume 11, Issue 4, Page 1200-1213, August 2026.
Abstract Objective Individuals with Down syndrome (DS) face an ultra‐high risk of Alzheimer's disease (AD). Within this continuum, Progressive Myoclonus Epilepsy (PME) has emerged as a marker of advanced neurodegeneration. Building on our 2014 characterization of this syndrome, we aimed to define its long‐term natural history and pathological substrate.
Giuseppe d'Orsi   +6 more
wiley   +1 more source

Hypersensitivity reaction risk when restarting cenobamate after discontinuation: Insights from a prolonged hospitalized cohort

open access: yesEpilepsia Open, Volume 11, Issue 4, Page 1255-1262, August 2026.
Abstract Objective To evaluate the risk of hypersensitivity reactions, including dermatological rashes, when cenobamate (CNB) is restarted at maintenance doses after temporary discontinuation. Methods We leveraged the natural experiment of long antiseizure medication discontinuation during intracranial EEG evaluation and conducted a retrospective ...
Marina Feldman   +4 more
wiley   +1 more source

Occurrence and clinical correlates of depressive symptoms in adults with epilepsy: A study in Georgia

open access: yesEpilepsia Open, Volume 11, Issue 4, Page 1290-1300, August 2026.
Abstract Objective To evaluate the occurrence, clinical correlates, and screening accuracy of depressive symptoms (DS) among adults with epilepsy in Georgia, a country with limited mental health resources. Methods We conducted a cross‐sectional study in adults with epilepsy attending a tertiary care center. We assessed DS using two validated tools: the
Ketevan Silagadze   +5 more
wiley   +1 more source

Polypharmacy burden and incident epilepsy among older adults in the United States

open access: yesEpilepsia Open, Volume 11, Issue 4, Page 1370-1381, August 2026.
Abstract Objectives To estimate the prevalence of polypharmacy among older adults with incident epilepsy and to describe the most common combinations of drug classes filled prior to epilepsy diagnosis. Polypharmacy—the concurrent use of multiple medications—is common in older adults with epilepsy, but little is known about its burden and specific ...
Galen Shearn‐Nance   +9 more
wiley   +1 more source

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