Results 201 to 210 of about 56,505 (288)

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2260-2272, October 2026.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Integrating machine learning and retrospective cohort to explore the effects of AEDs on the prognosis of LGG and identify related molecular targets. [PDF]

BMC Pharmacol Toxicol
Zhou M, Huang Q, Liang H, Yang H, Li M.
europepmc   +1 more source

Nerve conduction velocity in patients under longterm treatment with antiepileptic drugs [PDF]

, 1990
Krause, Klaus-Henning, Berlit, Peter
core  

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Genetic Polymorphisms <i>CYP3A4*22</i>, <i>CYP3A5*3</i>, and CYP2D6 Predicted Phenotypes Are Not Associated with Antipsychotic Treatment Outcomes in Neurotypical Prepubertal Boys with Conduct Disorders. [PDF]

Pharmaceuticals (Basel)
Ivashchenko DV, Che MD, Aysin FR, Tuchkova SN, Korsakov IN, Ianavichiute EI, Ivashchenko MA, Shimanov PV, Kondratieva RV, Shubin AV, Mirzaev KB, Shevchenko YS, Sychev DA.   +12 more
europepmc   +1 more source

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Antipsychotic use among paediatric patients living with epilepsy in Uganda. [PDF]

Sci Rep
Abaatyo J, Arinda A, Kawesi H, Kaggwa MM.   +3 more
europepmc   +1 more source

Peripartum Management of Vagus Nerve Stimulation and Antiseizure Medications During Two Pregnancies in a Woman With Drug‐Resistant Epilepsy: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT There are limited reports on vagus nerve stimulation (VNS) therapy during pregnancy. We report a case of two pregnancies in a woman with drug‐resistant epilepsy (DRE) managed with VNS. A woman with epilepsy underwent implantation of a VNS device because antiseizure medications (ASMs) and a lobectomy were not sufficient to control seizures ...
Motoki Ono, Ryoichi Asaka, Yasuhiro Tanaka, Chiho Fuseya, Norihiko Kikuchi, Tsutomu Miyamoto   +5 more
wiley   +1 more source

Systematic Management of a Critical CYP3A4 Interaction Between Cabozantinib and Carbamazepine: A Case Report of a Clinically Relevant Pharmacokinetic Interaction. [PDF]

Clin Case Rep
Nizet P, Huon JF, Viala C, Robin S, Ammor W.   +4 more
europepmc   +1 more source