Results 211 to 220 of about 56,505 (288)

Explore the Mechanism of Xiaoyaosan for Treatment of Bipolar Disorder Based on Network Pharmacology, Experimental Validation and Molecular Docking

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
This study evaluates Xiaoyaosan (XYS) for bipolar disorder (BD) using network pharmacology and experimental validation. Molecular docking reveals interactions between active XYS compounds and potential core targets. Animal experiments confirm XYS alleviates BD‐like behaviors in mice by suppressing core targets, elucidating its multi‐target mechanism ...
Man Chen, Nana Ding, Xingmin Qiu, Lan Li, Yali Guo, Rongyanqi Wang, Xiaowei Mo, Tan Zou, Shangzhen Yu, Xiaojuan Li, Jiaxu Chen   +10 more
wiley   +1 more source

HLA-A*32:01 and Lamotrigine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms.

JAMA Netw Open
Krantz MS, Zhou L, Wang L, Yu A, Gangula R, Ramirez-Valdez EA, Blackley S, Ostrov DA, Li D, Chopra A, Mallal S, Blumenthal K, Phillips EJ.   +12 more
europepmc   +1 more source

Exploratory prescribing risk profiles and drug drug interaction burden in older adults with depressive episodes. [PDF]

Front Psychiatry
Goldiş FD, Ardelean SM, Udrescu L.
europepmc   +1 more source

Development of a Predictive Flow Through Cell Dissolution Method for Carbamazepine Modified-Release Tablets. [PDF]

CPT Pharmacometrics Syst Pharmacol
Carvajal Barbosa L, Echeverry SM, Aragón DM.   +2 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling to Characterize the Disposition of Topiramate in Children with and without Obesity

The Journal of Clinical Pharmacology, Volume 66, Issue 10, October 2026.
Abstract Topiramate (TPM) is used to treat seizures in adults and children ≥2 years. In children, TPM dosing is body weight based. It is unknown whether children with obesity may benefit from an alternative dosing strategy. We developed a novel physiologically based pharmacokinetic (PBPK) model for TPM that accounts for age‐ and obesity‐related changes
Patricia D. Maglalang, Daniel Gonzalez, William J. Muller, Chi D. Hornik, Stuart L. Goldstein, Mobeen Rathore, Jennifer L. Ford, Stephen J. Balevic, Jaydeep Sinha, Andrea Edginton, Rachel G. Greenberg, Daniel K. Benjamin, Jia‐Yuh Chen, Kanecia O. Zimmerman, the Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee   +14 more
wiley   +1 more source

The Bright Side of the Spectrum: Self-Limited Infantile Epilepsy-Related SCN8A Gof Variant. [PDF]

Int J Dev Neurosci
Keskin F, Günay Ç, Doğan G, Baydan F, Sarıkaya Uzan G.   +4 more
europepmc   +1 more source

Updated Estimates of Agreement Between Dispensed Medications and Forensic Toxicology in Sweden

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 10, October 2026.
ABSTRACT Purpose To present updated estimates from a nationwide Swedish study comparing dispensed medications with forensic toxicological findings (2006–2013), following re‐evaluation of the toxicology dataset to address periods with non‐uniform analytical detection and inconsistent testing.
Heidi Taipale, Jari Tiihonen, Antti Tanskanen, Jonas Forsman   +3 more
wiley   +1 more source

Correction: Anticholinergic burden and health‑related quality of life among adult patients in a resource‑limited setting: a cross‑sectional study. [PDF]

Int J Clin Pharm
Gebreyohannes EA, Shibe BS, Taye WA, Lee K, Abdela OA, Ayele EM, Belachew EA, Mengistu SB, Myint PK, Soiza RL.   +9 more
europepmc   +1 more source

Environmental pollution and sustainable restoration of the Yamuna River: A review of water quality, health risks, and phycoremediation

River, Volume 5, Issue 3, Page 398-418, August 2026.
Abstract The Yamuna River, one of India's most significant river systems and the largest tributary of the Ganges River, serves critical ecological, socio‐economic, and cultural functions. However, rapid urbanization, industrialization, and intensive agriculture have severely degraded its water quality, resulting in extensive pollution with untreated ...
Dharmendra Kumar, Gaurav Kumar, Elangbam Geetanjali, Rashmi Shakya, Deepali Verma, Shivankar Agrawal, Dinabandhu Sahoo   +6 more
wiley   +1 more source

Medicine Use Preceding Fatal Poisonings Among Individuals With Bipolar Disorder

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Pharmacotherapy may reduce overall suicide risk in bipolar disorder, but prescribed medicines can also be causative agents in suicidal and accidental poisonings. This nationwide, nested case–control study utilized data from several national registers in Finland in 1996–2018.
Janina Salmelainen, Miia Tiihonen, Heidi Taipale, Johannes Lieslehto, Antti Tanskanen, Jari Tiihonen, Aleksi Hamina   +6 more
wiley   +1 more source