Results 211 to 220 of about 47,769 (294)

Distinct impacts of sodium channel blockers on the strength–duration properties of human motor cortex neurons

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to determine how voltage‐gated sodium channel (VGSC) blockers modulate cortical excitability in vivo. VGSCs are critical for regulating axonal excitability, yet the effects of sodium channel‐blocking medications on human cortical neurons remain poorly characterized.
Lorenzo Rocchi, Kate Brown, Alessandro Di Santo, Hannah Smith, Angel V. Peterchev, John C. Rothwell, Ricci Hannah   +6 more
wiley   +1 more source

L-quebrachitol Modulates the Anti-convulsant Effects of Carbamazepine Possibly Through Voltage-gated Sodium Channel Blocking Mechanism in Chicks: In Vivo and In Silico Studies. [PDF]

Brain Behav
Asrafi A, Aslam M, Alkhathami AG, Hossain MS, Rakib IH, Al Hasan MS, Nun FK, Amin MF, Islam MT.   +8 more
europepmc   +1 more source

Clinical studies on serum concentration of free fraction of phenytoin, carbamazepine and valproic acid.

, 1990
Jun Hosoya, HIDEYO NAGAOKA, SYU ISHIKAWA, Yoshito Nakagawa, Yoshiaki Higashitani, Shiro Totsuka   +5 more
openalex   +2 more sources

Real‐world retention of newer ASMs, including lacosamide and brivaracetam as first or second therapies in adult‐onset epilepsy

Epilepsia, EarlyView.
Abstract Objective Newer antiseizure medications (ASMs), such as lacosamide and brivaracetam, have promising retention in clinical trials but real‐world data on their effectiveness when used as first or second treatments is missing. Because newer ASMs are often reserved for severe cases, such knowledge accumulates slowly.
André Idegård, David Larsson, Johan Zelano   +2 more
wiley   +1 more source

Severe carbamazepine-induced cardiotoxicity with multisystem involvement: early recognition and advanced therapeutic approach. [PDF]

Arch Clin Cases
Haliga RE, Coman AE, Mihai RI, Morarasu BC, Ceasovschih A, Sorodoc V.   +5 more
europepmc   +1 more source

Unmasking the role of the occipital lobe in epilepsy with eyelid myoclonia

Epilepsia, EarlyView.
Emilia Ricci, Tomasz Stanislaw Mieszczanek, Monica Zilmer, Katarzyna Cebula, Stefan Juhl, Marina Nikanorova, Katarzyna Maria Mieszczanek, Marianne Søndergaard Khinchi, Britta Inga Ulfsdotter Hesslow, Kristin Siølie Thygesen, Charlotte Reinhardt Pedersen, Kern Olofsson, Stephan Wüstenhagen, Rikke S Møller, Guido Rubboli, Sándor Beniczky, Elena Gardella   +16 more
wiley   +1 more source

The gut microbiome associated with LGI1‐antibody encephalitis

Epilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis is a cause of brain inflammation characterized by auto‐antibodies, which target cell surface neuronal proteins and lead to neuronal dysfunction. The most common form is associated with auto‐antibodies to leucine‐rich glioma‐inactivated 1 (LGI1) protein, the presentation of which includes frequent focal ...
Edmund Gilbert, Sophie Binks, Valentina Damato, Christopher Uy, Paula Colmenero, Mark Kelly, Mohamed Ibrahim Khalil, Marcus O'Brien, Marcus J Claesson, John F. Cryan, Norman Delanty, Sarosh R. Irani, Gianpiero L. Cavalleri   +12 more
wiley   +1 more source

Medications, epilepsy and climate change: Added layers of complexity. [PDF]

Br J Clin Pharmacol
Gulcebi MI, Gavas S, Sisodiya SM.
europepmc   +1 more source

Time Courses of Carbamazepine and Carbamazepine-10, 11-Epoxide Levels in Rat Brain and Blood Following Single Oral Administration of Carbamazepine as Examined by In Vivo Microdialysis.

, 1994
Ruriko Takahashi
openalex   +2 more sources

Topiramate for the treatment of neonatal seizures and beyond

Epilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source