Results 71 to 80 of about 110,777 (250)

Increasing proportion of carbapenemase-producing Enterobacteriaceae and emergence of a MCR-1 producer through a multicentric study among hospital-based and private laboratories in Belgium from September to November 2015 [PDF]

, 2017
Carbapenemase-producing Enterobacteriaceae (CPE) strains have been increasingly reported in Belgium. We aimed to determine the proportion of CPE among Enterobacteriaceae isolated from hospitalised patients and community outpatients in Belgium in 2015 ...
Bauraing, Caroline, Berhin, Catherine, Boelens, Jerina, Bogaerts, Pierre, Claeys, Geert, Glupczynski, Youri, Hoebeke, Martin, Huang, Te Din, multicentre study group, on behalf of a   +8 more
core   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

Mathematical Modeling of Amoxicillin Synthesis in Batch and Semi‐Batch Reactor: Application of Bayesian Statistics and Genetic Algorithm

Biotechnology and Bioengineering, EarlyView.
Synthesis of amoxicillin: The reaction catalyzed by penicillin G acylase is investigated in an enzymatic reactor, considering both Michaelis–Menten and mechanism‐based models with reaction and equilibrium constants. Parameters are estimated via MCMC and Genetic Algorithm, with MCMC showing superior performance in validating the mathematical model in a ...
Lucas Figueiredo Formigosa, Ingrid Cabral dos Santos, Letícia Eduarda Alves e Álvares, Emanuel Negrão Macêdo, Luciana Rocha Barros Gonçalves, Bruno Marques Viegas   +5 more
wiley   +1 more source

Molecular Characteristics and Quantitative Proteomic Analysis of Klebsiella pneumoniae Strains with Carbapenem and Colistin Resistance

Antibiotics, 2022
Carbapenem-resistant Klebsiella pneumoniae (CRKP) are usually multidrug resistant (MDR) and cause serious therapeutic problems. Colistin is a critical last-resort therapeutic option for MDR bacterial infections.
Ling Hao, Xiao Yang, Huiling Chen, Zexun Mo, Yujun Li, Shuquan Wei, Ziwen Zhao   +6 more
doaj   +1 more source

EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA): a protocol of a European multicentre observational study [PDF]

, 2017
Introduction: The rapid worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) constitutes a major challenge. The aim of the EUropean prospective cohort study on Enterobacteriaceae showing REsistance to CArbapenems (EURECA), which is part
Bravo Ferrer, José, Gutiérrez Gutiérrez, Belén, Pascual Hernández, Álvaro (Coordinador), Rodriguez Baño, Jesus, Sojo Dorado, Jesús   +4 more
core  

Antimicrobial Resistance: We Must Pursue a Collaborative, Global Approach and Use a "One Health" Approach. [PDF]

, 2019
Treating infection is a key part of the work of most clinicians [...]
Lipman, J, Lonsdale, DO
core   +1 more source

A Promising Antibacterial Inhibition of Propolis Extracts Against Carbapenem‐Resistant Bacteria Isolated From Clinical Samples

Chemistry &Biodiversity, EarlyView.
ABSTRACT The increasing inadequacy of antibiotics against multidrug‐resistant pathogens is a growing concern. In this study, the antibacterial activity of propolis extracts with different phenolic profiles against carbapenem‐resistant clinical isolates was investigated.
Ülkü Zeynep Esertaş, Neşe Inal, Zehra Can, Sevgi Kolaylı   +3 more
wiley   +1 more source

Evaluation of the Blue-Carba test for rapid detection of carbapenemases in gram-negative Bacilli [PDF]

, 2015
The Blue-Carba test (BCT) is a biochemical test for rapid (2 h)detection of carbapenemase production in Gram-negative bacillidirectly from bacterial culture .
Albornoz, Ezequiel Pablo, Ceriana, Paola, Corso, Alejandra, Gómez, Sonia Alejandra, Lucero, María Celeste, Pasteran, Fernando, Rapoport, Melina, Veliz, Omar   +7 more
core   +1 more source

Development and Validation of a High‐Throughput Screening Assay for the Legionella ADP‐Ribosyl Transferase SdeA

ChemBioChem, EarlyView.
We show the optimization and application of a fluorogenic assay to monitor Legionella SdeA activity in a High‐Throughput‐Screening campaign. Ubiquitination of proteins is one of the most crucial post‐translational modifications in eukaryotic cells, typically involving conjugation of ubiquitin to a lysine residue in a substrate using a three‐enzyme ...
Halana C. Vlaming, Vito Pol, Bjorn R. van Doodewaerd, Angeliki Moutsiopoulou, Paul P. Geurink, Robbert Q. Kim, Gerbrand J. van der Heden van Noort   +6 more
wiley   +1 more source

Carbapenem-resistant Pseudomonas aeruginosa outbreak in an intensive care unit of a teaching hospital

Brazilian Journal of Infectious Diseases
The genetic similarity of carbapenem-resistant Pseudomonas aeruginosa strains isolated in the Hospital Universitário São Francisco, Bragança Paulista, São Paulo, Brasil, was evaluated by pulsed field gel electrophoresis (PFGE).
Ana C. Gales, Patrícia L. Torres, Dominique S. O. Vilarinho, Renata S. Melo, Claudinéia F. L. Silva, Rosângela F. Cereda   +5 more
doaj   +1 more source