Results 201 to 210 of about 29,439 (214)
Some of the next articles are maybe not open access.
Carbapenemase-bildende Enterobakterien (CBE)
Endo-Praxis, 2022Carbapenemasen sind bakterielle Enzyme, die Carbapeneme und andere Beta-Laktam-Antibiotika inaktivieren. Viele gramnegative Spezies, darunter vor allem Enterobakterien, können Carbapenemasen bilden, was die therapeutischen Möglichkeiten im Infektionsfall stark einschränkt.
Yvonne Pfeifer +3 more
openaire +1 more source
Carbapenemases: a worldwide threat
Expert Review of Anti-infective Therapy, 2013β-lactam antibiotics remain one of our workhorse classes for serious infection due to their usually broad activity and attractive safety profile.
openaire +2 more sources
Clinically significant carbapenemases: an update
Current Opinion in Infectious Diseases, 2008To provide a brief synopsis of studies which have extended our understanding of carbapenem resistance in clinical isolates in terms of epidemiology, mechanism of action and genetic factors affecting their carriage and spread.Studies published in the last 18 months continue to confirm that VIM-2 is the dominant metallo-beta-lactamase in Pseudomonas ...
openaire +2 more sources
Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae
Journal of Infusion Nursing, 2010Carbapenem-resistant Enterobacteriaceae, particularly Klebsiella pneumoniae, are rapidly emerging as significant health care-associated pathogens. Because of the adverse impact that infection caused by these extensively drug-resistant organisms can have on patient outcomes, efforts to prevent further transmission of these pathogens within the health ...
openaire +2 more sources
[Carbapenemases in enterobacteriaceae].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2011Carbapenem-hydrolyzing beta-lactamases are the most powerful mechanism of resistance to carbapenems. Carbapenemases have been reported extensively worldwide now in Enterobacteriaceae. Carbapenemases of the KPC type have been reported first from the USA in Klebsiella pneumoniae, then worldwide with a marked endemicity in Israel and Greece.
P, Nordmann, A, Carrer
openaire +1 more source
Emerging carbapenemases: a global perspective
International Journal of Antimicrobial Agents, 2010The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants.
openaire +2 more sources
Over-treatment of carbapenemase-producing Enterobacteriaceae
Scandinavian Journal of Infectious Diseases, 2011To describe the treatment and outcomes of patients with carbapenemase-producing Enterobacteriaceae and evaluate whether these cases represented active infection requiring antibiotic therapy or colonization.Adult inpatients with carbapenemase-producing Enterobacteriaceae were retrospectively evaluated.
Deba S, Rihani +6 more
openaire +2 more sources
[Carbapenemases in Pseudomonas spp].
Enfermedades infecciosas y microbiologia clinica, 2010Pseudomonas aeruginosa is one of the most relevant nosocomial pathogens, as well as one of the main causes of chronic respiratory infections in patients with underlying diseases such as cystic fibrosis or chronic obstructive pulmonary disease. The high intrinsic antibiotic resistance of this pathogen, together with its extraordinary capacity for ...
Carlos, Juan Nicolau, Antonio, Oliver
openaire +1 more source
Azetidinimines as carbapenemases inhibitors
2017The present application relates to novel azetidinimine of formula (I). Wherein R1-R6 are as defined in claim 1. The azetidinimine of the invention are useful as antibiotics and as inhibitors of a carbapenemases. The present invention thus further relates totheir use in antibiotic therapies and their methods of synthesis.
Dodd, Robert +4 more
openaire +1 more source