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Carbapenemase-producing , Algeria

, 2010
Drissi, M., Poirel, L., Mugnier, P. D., Baba Ahmed, Z., Nordmann, P.   +4 more
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The emerging NDM carbapenemases

Trends in Microbiology, 2011
Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian
Nordmann, Patrice, Poirel, Laurent, Walsh, Timothy R, Livermore, David M   +3 more
openaire   +5 more sources

Carbapenemase-Producing Organisms: A Global Scourge [PDF]

Clinical Infectious Diseases, 2018
The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern.
Robert A Bonomo, Eileen M Burd, John Conly   +2 more
exaly   +1 more source

Carbapenemase inhibitors

Reviews in Medical Microbiology, 2017
Carbapenemase inhibitors play a critically important role in prevention of carbapenem resistance. In the current review, based on studied articles from PubMed, Google Scholar and Scopus, we summarize the current state of carbapenemase inhibitors and their importance in clinical use.
Mina Aghamali, Abed Zahedi Bialvaei, Mohammad Aghazadeh, Mohammad Asgharzadeh, Hossein Samadi Kafil   +4 more
openaire   +1 more source

Rapid LC–MS/MS detection of different carbapenemase types in carbapenemase-producing Enterobacterales

European Journal of Clinical Microbiology & Infectious Diseases, 2022
Klebsiella pneumoniae carbapenemase (KPC)-2, metallo-beta-lactamases (MBL), and oxacillinase (OXA)-48-like carbapenemases are considered the most important carbapenemases. In vitro studies have demonstrated that the carbapenemase activity of KPC-2 and MBL can be inhibited by 3-aminophenylboronic acid and ethylenediaminetetraacetic acid (EDTA ...
Gen Li, Zhihan Ye, Wenyan Zhang, Nianzhen Chen, Yangqin Ye, Yuchao Wang, Fei Wu, Keli Wang, Lieying Fan   +8 more
openaire   +2 more sources

Carbapenemases: a worldwide threat

Expert Review of Anti-infective Therapy, 2013
β-lactam antibiotics remain one of our workhorse classes for serious infection due to their usually broad activity and attractive safety profile.
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Current methods for the identification of carbapenemases

Journal of Chemotherapy, 2016
Detection of carbapenemases in clinical microbiology labs is a challenging issue. Comparison of the results of susceptibility testing with the breakpoint values of carbapenems is the first step in the screening of carbapenemase producers. To date, screening of carbapenemase-producing (CP) bacteria has been mostly performed by a selective medium ...
Abed Zahedi, Bialvaei, Hossein Samadi, Kafil, Mohammad, Asgharzadeh, Mohammad, Yousef Memar, Mehdi, Yousefi   +4 more
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Detection systems for carbapenemase gene identification should include the SME serine carbapenemase

International Journal of Antimicrobial Agents, 2013
Carbapenemase detection has become a major problem in hospitals that encounter outbreaks of infections caused by carbapenem-resistant Gram-negative bacteria. Rapid detection systems have been reported using multiplex PCR analyses and DNA microarray assays.
Karen, Bush, Megan, Pannell, John L, Lock, Anne Marie, Queenan, James H, Jorgensen, Ryan M, Lee, James S, Lewis, Deidre, Jarrett   +7 more
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Development and evaluation of the method for detecting metallo-carbapenemases among carbapenemase-producing Enterobacteriaceae

Journal of Microbiological Methods, 2019
A simple EDTA synergistic carbapenem inactivation method (esCIM) based on the simplified carbapenem inactivation method (sCIM) and EDTA synergistic carbapenem inactivation test (eCIM) detected the levels of metallo-β-lactamases (MBLs) carbapenemase.
Quanfeng, Liao, Yun, Xie, Chengcheng, Wang, Zhiyong, Zong, Siying, Wu, Ya, Liu, Weili, Zhang, Yi, Xie, Yuling, Xiao, Mei, Kang   +9 more
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Clinically significant carbapenemases: an update

Current Opinion in Infectious Diseases, 2008
To provide a brief synopsis of studies which have extended our understanding of carbapenem resistance in clinical isolates in terms of epidemiology, mechanism of action and genetic factors affecting their carriage and spread.Studies published in the last 18 months continue to confirm that VIM-2 is the dominant metallo-beta-lactamase in Pseudomonas ...
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