Results 191 to 200 of about 46,917 (222)

Carbapenemase inhibitors

Reviews in Medical Microbiology, 2017
Carbapenemase inhibitors play a critically important role in prevention of carbapenem resistance. In the current review, based on studied articles from PubMed, Google Scholar and Scopus, we summarize the current state of carbapenemase inhibitors and their importance in clinical use.
Mina Aghamali, Abed Zahedi Bialvaei, Mohammad Aghazadeh, Mohammad Asgharzadeh, Hossein Samadi Kafil   +4 more
openaire   +1 more source

Rapid LC–MS/MS detection of different carbapenemase types in carbapenemase-producing Enterobacterales

European Journal of Clinical Microbiology & Infectious Diseases, 2022
Klebsiella pneumoniae carbapenemase (KPC)-2, metallo-beta-lactamases (MBL), and oxacillinase (OXA)-48-like carbapenemases are considered the most important carbapenemases. In vitro studies have demonstrated that the carbapenemase activity of KPC-2 and MBL can be inhibited by 3-aminophenylboronic acid and ethylenediaminetetraacetic acid (EDTA ...
Gen Li, Zhihan Ye, Wenyan Zhang, Nianzhen Chen, Yangqin Ye, Yuchao Wang, Fei Wu, Keli Wang, Lieying Fan   +8 more
openaire   +2 more sources

Detection systems for carbapenemase gene identification should include the SME serine carbapenemase

International Journal of Antimicrobial Agents, 2013
Carbapenemase detection has become a major problem in hospitals that encounter outbreaks of infections caused by carbapenem-resistant Gram-negative bacteria. Rapid detection systems have been reported using multiplex PCR analyses and DNA microarray assays.
Karen, Bush, Megan, Pannell, John L, Lock, Anne Marie, Queenan, James H, Jorgensen, Ryan M, Lee, James S, Lewis, Deidre, Jarrett   +7 more
openaire   +2 more sources

Carbapenemase-bildende Enterobakterien (CBE)

Endo-Praxis, 2022
Carbapenemasen sind bakterielle Enzyme, die Carbapeneme und andere Beta-Laktam-Antibiotika inaktivieren. Viele gramnegative Spezies, darunter vor allem Enterobakterien, können Carbapenemasen bilden, was die therapeutischen Möglichkeiten im Infektionsfall stark einschränkt.
Yvonne Pfeifer, Sebastian Wendt, Norman Lippmann, Christoph Lübbert   +3 more
openaire   +1 more source

Carbapenemases: a worldwide threat

Expert Review of Anti-infective Therapy, 2013
β-lactam antibiotics remain one of our workhorse classes for serious infection due to their usually broad activity and attractive safety profile.
openaire   +2 more sources

Clinically significant carbapenemases: an update

Current Opinion in Infectious Diseases, 2008
To provide a brief synopsis of studies which have extended our understanding of carbapenem resistance in clinical isolates in terms of epidemiology, mechanism of action and genetic factors affecting their carriage and spread.Studies published in the last 18 months continue to confirm that VIM-2 is the dominant metallo-beta-lactamase in Pseudomonas ...
openaire   +2 more sources

Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae

Journal of Infusion Nursing, 2010
Carbapenem-resistant Enterobacteriaceae, particularly Klebsiella pneumoniae, are rapidly emerging as significant health care-associated pathogens. Because of the adverse impact that infection caused by these extensively drug-resistant organisms can have on patient outcomes, efforts to prevent further transmission of these pathogens within the health ...
openaire   +2 more sources

[Carbapenemases in enterobacteriaceae].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2011
Carbapenem-hydrolyzing beta-lactamases are the most powerful mechanism of resistance to carbapenems. Carbapenemases have been reported extensively worldwide now in Enterobacteriaceae. Carbapenemases of the KPC type have been reported first from the USA in Klebsiella pneumoniae, then worldwide with a marked endemicity in Israel and Greece.
P, Nordmann, A, Carrer
openaire   +1 more source

Emerging carbapenemases: a global perspective

International Journal of Antimicrobial Agents, 2010
The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants.
openaire   +2 more sources

Over-treatment of carbapenemase-producing Enterobacteriaceae

Scandinavian Journal of Infectious Diseases, 2011
To describe the treatment and outcomes of patients with carbapenemase-producing Enterobacteriaceae and evaluate whether these cases represented active infection requiring antibiotic therapy or colonization.Adult inpatients with carbapenemase-producing Enterobacteriaceae were retrospectively evaluated.
Deba S, Rihani, Mark R, Wallace, Barry E, Sieger, Robert A, Waite, Marlena, Fox, Scott A, Brown, C Andrew, Deryke   +6 more
openaire   +2 more sources