Results 1 to 10 of about 18,841 (138)

Molecular characterization and comparison of bla NDM-1 -carrying and bla NDM-5 -harboring IncX3-type plasmids in carbapenem-resistant Klebsiella pneumoniae

Microbiology Spectrum, 2023
Carbapenem-resistant Klebsiella pneumoniae (CRKP), which harbors the bla NDM plasmid, has been reported extensively and is considered a global threat clinically.
Yunxing Yang, Longjie Zhou, Darong Duan   +2 more
exaly   +3 more sources

Production of plasmid-encoding NDM-1 in clinical Raoultella ornithinolytica and Leclercia adecarboxylata from China

Frontiers in Microbiology, 2015
Raoultella ornithinolytica YNKP001 and Leclercia adecarboxylata P10164, harboring conjugative plasmids pYNKP001-NDM and pP10164-NDM with determination of complete nucleotide sequences, respectively, were isolated from two different Chinese patients ...
Fengjun Sun, , Dongsheng Zhou
exaly   +3 more sources

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Scientific Reports, 2021
Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases.
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel   +9 more
doaj   +1 more source

Antibiotic-resistance genes in E. coli strains in GCC countries: A meta-analysis

Saudi Journal of Medicine and Medical Sciences, 2022
Background: Antimicrobial resistance (AMR) in Escherichia coli is an alarming issue worldwide, including in the Gulf Cooperation Council (GCC) countries, yet the prevailing gene patterns have not recently been reviewed.
Khalid Mubarak Bindayna, Ronni Mol Joji, Hicham Ezzat, Haitham Ali Jahrami   +3 more
doaj   +1 more source

Genotypic Distribution and Antimicrobial Susceptibilities of Carbapenemase-Producing Enterobacteriaceae Isolated in Tertiary Care Hospital in South India

Journal of Pure and Applied Microbiology, 2022
Antimicrobial resistance has emerged as a major danger to contemporary medicine around the world. Carbapenems are the highest class of B-lactam drugs which are considered as the most effective and safest antibiotics available.
S. Abhishek, Shweta Sagar Naik, K.V. Leela, D. Maheswary   +3 more
doaj   +1 more source

Genomic transmission analysis of multidrug-resistant Gram-negative bacteria within a newborn unit of a Kenyan tertiary hospital: A four-month prospective colonization study

Frontiers in Cellular and Infection Microbiology, 2022
ObjectiveMultidrug-resistant organisms (MDRO), especially carbapenem-resistant organisms (CRO), represent a threat for newborns. This study investigates the colonization prevalence of these pathogens in a newborn unit at a Kenyan tertiary hospital in an ...
David Villinger, David Villinger, David Villinger, Tilman G. Schultze, Tilman G. Schultze, Tilman G. Schultze, Victor M. Musyoki, Irene Inwani, Jalemba Aluvaala, Lydia Okutoyi, Anna-Henriette Ziegler, Imke Wieters, Imke Wieters, Christoph Stephan, Christoph Stephan, Beatrice Museve, Volkhard A. J. Kempf, Volkhard A. J. Kempf, Volkhard A. J. Kempf, Moses Masika   +19 more
doaj   +1 more source

Author Correction: A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel   +9 more
doaj   +1 more source

The First Experience of Combined Use of Cefepime/Sulbactam and Aztreonam in ICU Patients with Nosocomial Infections Caused by Carbapenem-Resistant Gram-Negative Microorganisms Producing Class B and D Carbapenemases

Антибиотики и Химиотерапия, 2023
Background. The difficulties of antibacterial therapy of infections caused by carbapenemase-producing  gram-negative bacteria are associated with limited options for adequate therapy since, in addition to resistance to carbapenems and other beta-lactams ...
M. P. Suvorova, I. N. Sychev, O. V. Ignatenko, E. N. Burmistrova, S. S. Mirzakhamidova, L. V. Fedina, R. M. Vakolyuk, S. V. Yakovlev   +7 more
doaj   +1 more source

The Changing Epidemiology of Carbapenemase-Producing Enterobacterales

Rambam Maimonides Medical Journal, 2022
Objective Israeli hospitals were confronted with a major national outbreak of carbapenemase-producing Enterobacterales (CPE) starting in 2006, caused predominantly by monoclonal Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ...
Khetam Hussein, Yuval Geffen, Orna Eluk, Sigal Warman, Worood Aboalheja, Tamar Alon, Ibrahim Firan, Mical Paul   +7 more
doaj   +1 more source

The uncertain role of substandard and falsified medicines in the emergence and spread of antimicrobial resistance

Nature Communications, 2023
Approximately 10% of antimicrobials used by humans in low- and middle-income countries are estimated to be substandard or falsified. In addition to their negative impact on morbidity and mortality, they may also be important drivers of antimicrobial ...
Sean Cavany, Stella Nanyonga, Cathrin Hauk, Cherry Lim, Joel Tarning, Benn Sartorius, Christiane Dolecek, Céline Caillet, Paul N. Newton, Ben S. Cooper   +9 more
doaj   +1 more source