Results 1 to 10 of about 24,184 (203)

Rapidly spreading Enterobacterales with OXA-48-like carbapenemases [PDF]

Journal of Clinical Microbiology
Enterobacterales (mostly Klebsiella pneumoniae, Escherichia coli) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy. In the Middle East, North Africa, and some European countries,
Gisele Peirano, Johann D. D. Pitout
doaj   +4 more sources

To Be or Not to Be an OXA-48 Carbapenemase [PDF]

Microorganisms, 2022
Since the first description of OXA-48, more than forty variants have been recovered from Enterobacterales isolates. Whereas some OXA-48-related enzymes have been reported as conferring similar resistance patterns, namely, the hydrolysis of carbapenems ...
Laura Dabos, Saoussen Oueslati, Sandrine Bernabeu, Rémy A. Bonnin, Laurent Dortet, Thierry Naas   +5 more
doaj   +3 more sources

The Global Ascendency of OXA-48-Type Carbapenemases [PDF]

Clinical Microbiology Reviews, 2019
Surveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks. OXA-48, OXA-181, OXA-232, OXA-204, OXA-
Yasufumi Matsumura, Marleen Kock, Johann Pitout   +2 more
exaly   +3 more sources

Comparative evaluation of a novel chromogenic medium (chromID OXA-48) for detection of OXA-48 producing Enterobacteriaceae [PDF]

Diagnostic Microbiology and Infectious Disease, 2013
Comparative evaluation of the recently developed chromogenic culture medium chromID OXA-48 (bioMérieux) with chromID CARBA (bioMérieux) and SUPERCARBA showed that chromID OXA-48 and SUPERCARBA media have the highest sensitivity for detection of OXA-48 producing Enterobacteriaceae (91% and 93%) comparatively to chromID CARBA (21 %).
Nordmann Patrice, Delphine Girlich, Gilles Zambardi   +2 more
exaly   +4 more sources

Role of Arginine 214 in the Substrate Specificity of OXA-48 [PDF]

Antimicrobial Agents and Chemotherapy, 2020
Increasing numbers of variants of the carbapenem-hydrolyzing class D β-lactamase OXA-48 are identified in Enterobacterales worldwide. Among them, OXA-181 and OXA-232 are of particular interest, as they differ from each other by a single amino acid substitution at position 214 (R in OXA-181 and S in OXA-232) that ...
Laurent Dortet, Thierry Naas, Remy A Bonnin   +2 more
exaly   +3 more sources

Emergence of OXA-48-like Carbapenemase-Producing Escherichia coli in Baranya County, Hungary [PDF]

Antibiotics
Background: Carbapenem-resistant Escherichia coli (CREC) producing OXA-48-like carbapenemase was first detected in Hungary in 2022. The aim of the present study was to characterize such strains isolated in 2022–2025 in Baranya County, Hungary.
Fatma A. Mohamed, Mohamed Al-Bulushi, Szilvia Melegh, Bálint Timmer, Réka Meszéna, Csongor Freytag, Levente Laczkó, László Miló, Péter Urbán, Renáta Bőkényné-Tóth, Attila Gyenesei, Gábor Kardos, Adrienn Nyul, Edit Urbán, Tibor Pál, Ágnes Sonnevend   +15 more
doaj   +2 more sources

Genetic characteristics of OXA-48-producing Enterobacterales from China

Journal of Global Antimicrobial Resistance, 2021
: Objectives: In China, OXA-48-producing Enterobacterales have been identified sporadically, causing small-scale regional outbreaks. This study investigated the molecular epidemiology, transmission and evolution of OXA-48-producing Enterobacterales and ...
Lifeng Wang, Ling Guo, Kun Ye, Jiyong Yang   +3 more
doaj   +3 more sources

Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness [PDF]

Frontiers in Microbiology, 2019
OXA-48 is the most common carbapenemase in Enterobacterales in Germany and one of the most frequent carbapenemases worldwide. Several reports have associated blaOXA–48 with a virulent host phenotype.
Axel Hamprecht, Julian Sommer, Matthias Willmann, Christina Brender, Yvonne Stelzer, Felix F. Krause, Tsvetan Tsvetkov, Florian Wild, Sara Riedel-Christ, Julia Kutschenreuter, Can Imirzalioglu, Aitor Gonzaga, Ulrich Nübel, Ulrich Nübel, Stephan Göttig   +14 more
doaj   +4 more sources

Detection of OXA-48-Carbapenemase-Producing Enterobacteriaceae using ChromID OXA-48 in Critical Care Patients in Egypt

Journal of Pure and Applied Microbiology, 2017
Carbapenems are a class of beta-lactam antibiotics with broad spectrum of activity. They are often considered as a last resort in treatment of infections caused by multidrug resistant organisms.
Basma A. El Awady, Mera G. Anan, Hamida A. Gohar, Mohamed H. Saleh   +3 more
doaj   +2 more sources

Arising Prevalence of OXA-48 producer Escherichia coli and OXA-48 with NDM co-producer Klebsiella pneumoniae Strains [PDF]

Romanian Journal of Laboratory Medicine, 2019
Background/aim: This prospective study aimed to determine the presence of the most common carbapenemase genes, blaOXA-48, blaKPC, blaIMP, blaVIM and blaNDM on carbapenem resistant clinical K.pneumoniae and E.coli isolates. Materials and methods: Isolates
Uskudar-Guclu Aylin, Guney Mustafa, Sig Ali Korhan, Kilic Selcuk, Baysallar Mehmet   +4 more
doaj   +2 more sources