Results 1 to 10 of about 1,076,076 (217)

To Be or Not to Be an OXA-48 Carbapenemase [PDF]

Microorganisms, 2022
Since the first description of OXA-48, more than forty variants have been recovered from Enterobacterales isolates. Whereas some OXA-48-related enzymes have been reported as conferring similar resistance patterns, namely, the hydrolysis of carbapenems and penicillins with very weak or almost no activity against expanded-spectrum cephalosporins, some ...
Laura Dabos, Saoussen Oueslati, Sandrine Bernabeu, Rémy A. Bonnin, Laurent Dortet, Thierry Naas   +5 more
core   +5 more sources

Rapidly spreading Enterobacterales with OXA-48-like carbapenemases. [PDF]

J Clin Microbiol
ABSTRACT Enterobacterales (mostly Klebsiella pneumoniae , Escherichia coli ) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy.
Peirano G, Pitout JDD.
europepmc   +5 more sources

Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness [PDF]

Frontiers in Microbiology, 2019
OXA-48 is the most common carbapenemase in Enterobacterales in Germany and one of the most frequent carbapenemases worldwide. Several reports have associated bla OXA - 48 with a virulent host phenotype. To challenge this hypothesis, 35 OXA-48-producing clinical isolates of Escherichia coli (n = 15) and Klebsiella pneumoniae (n = 20) were studied in ...
Axel Hamprecht, Julian Sommer, Matthias Willmann, Christina Brender, Yvonne Stelzer, Felix F. Krause, Tsvetan Tsvetkov, Florian Wild, Sara Riedel-Christ, Julia Kutschenreuter, Can Imirzalioglu, Aitor Gonzaga, Ulrich Nübel, Ulrich Nübel, Stephan Göttig   +14 more
core   +6 more sources

Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48 [PDF]

ACS Infectious Diseases, 2021
Despite the advances in β-lactamase inhibitor development, limited options exist for the class D carbapenemase known as OXA-48. OXA-48 is one of the most prevalent carbapenemases in carbapenem-resistant Enterobacteriaceae infections and is not susceptible to most available β-lactamase inhibitors. Here, we screened various low-molecular-weight compounds
Doris Mia Taylor, Justin Anglin, Liya Hu, Lingfei Wang, Banumathi Sankaran, Jin Wang, Martin M. Matzuk, B. V. Venkataram Prasad, Timothy Palzkill   +8 more
openaire   +4 more sources

Evaluation of a New Phenotypic OXA-48 Disk Test for Differentiation of OXA-48 Carbapenemase-Producing Enterobacteriaceae Clinical Isolates [PDF]

Journal of Clinical Microbiology, 2015
ABSTRACT The current phenotypic methods for detecting carbapenemase-producing Enterobacteriaceae (CPE) allow differentiation between class A and B carbapenemases, but they cannot confirm in a single test class D OXA-48 carbapenemase producers.
Tsakris, A., Poulou, A., Bogaerts, P., Dimitroulia, E., Pournaras, S., Glupczynski, Y.   +5 more
core   +5 more sources

The Global Ascendency of OXA-48-Type Carbapenemases [PDF]

Clinical Microbiology Reviews, 2019
Surveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks. OXA-48, OXA-181, OXA-232, OXA-204, OXA-
Johann D D Pitout, Gisele Peirano, Marleen M Kock   +2 more
exaly   +3 more sources

Role of Arginine 214 in the Substrate Specificity of OXA-48 [PDF]

Antimicrobial Agents and Chemotherapy, 2020
Increasing numbers of variants of the carbapenem-hydrolyzing class D β-lactamase OXA-48 are identified in Enterobacterales worldwide. Among them, OXA-181 and OXA-232 are of particular interest, as they differ from each other by a single amino acid substitution at position 214 (R in OXA-181 and S in OXA-232) that ...
Saoussen Oueslati, Pascal Retailleau, Laurent Dortet   +2 more
exaly   +3 more sources

Emergence of OXA-48 Carbapenemase in Taiwan

Journal of Microbiology, Immunology and Infection, 2015
[[abstract]]Purpose: OXA-48 producing Enterbacteriaceae are increased dramatically in Mediterranean countries in the past ten years. It has been found in Asia recently. Here, we report the emergence of OXA-48 during a nationwide survey in Taiwan. Methods:
Ma, Ling, Chen, Peijing, Lin, Fumei, Ding, Yijiun, Huang, Liyue, Chang, Jenchang, Liu, Qihong, Tai, Yukuo, Lu, Poliang   +8 more
openaire   +2 more sources

Comparative evaluation of a novel chromogenic medium (chromID OXA-48) for detection of OXA-48 producing Enterobacteriaceae [PDF]

Diagnostic Microbiology and Infectious Disease, 2013
Comparative evaluation of the recently developed chromogenic culture medium chromID OXA-48 (bioMérieux) with chromID CARBA (bioMérieux) and SUPERCARBA showed that chromID OXA-48 and SUPERCARBA media have the highest sensitivity for detection of OXA-48 producing Enterobacteriaceae (91% and 93%) comparatively to chromID CARBA (21 %).
Delphine Girlich, Gilles Zambardi, Patrice Nordmann   +2 more
exaly   +4 more sources

Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]

Journal of Antimicrobial Chemotherapy, 2015
Abstract Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Oueslati S, Nordmann P, Poirel L
openaire   +6 more sources