Results 1 to 10 of about 17,417 (187)

Rapidly spreading Enterobacterales with OXA-48-like carbapenemases [PDF]

Journal of Clinical Microbiology
Enterobacterales (mostly Klebsiella pneumoniae, Escherichia coli) with OXA-48-like carbapenemases (e.g., OXA-48, -181, -232, -244) are undermining the global efficiency of carbapenem therapy. In the Middle East, North Africa, and some European countries,
Gisele Peirano, Johann D. D. Pitout
doaj   +4 more sources

Unveiling the Emergence and Genetic Diversity of OXA-48-like Carbapenemase Variants in Shewanella xiamenensis [PDF]

Microorganisms, 2023
An increase in the carbapenem-hydrolyzing capacity of class D β-lactamase has been observed in strains of multiple species, posing a significant challenge to the control of antibiotic resistance.
Xueqi Jiang, Beibei Miao, Xiaofei Zhao, Xuemei Bai, Min Yuan, Xia Chen, Xinyi Gong, Zeliang Liu, Jie Li, Shuang Meng, Xiao Han, Juan Li   +11 more
doaj   +4 more sources

Performance of disk diffusion, gradient test, and VITEK 2 for carbapenem susceptibility testing in OXA-48-like carbapenemase-producing Enterobacterales: a comparative study [PDF]

Journal of Clinical Microbiology
This study aimed to compare the performance of disk diffusion, gradient test (ETEST), and VITEK 2 (AST-N223, AST-N428, AST-N432 cards) antibiotic susceptibility testing methods with the reference broth microdilution (BMD) for carbapenem susceptibility in
Cansu Cimen, Philipp Siemer, Janko Sattler, Andreas Voss, Matthijs S. Berends, Axel Hamprecht   +5 more
doaj   +5 more sources

OXA-48-like carbapenemases in Proteus mirabilis – novel genetic environments and a challenge for detection [PDF]

Emerging Microbes and Infections
OXA-48-like enzymes represent the most frequently detected carbapenemases in Enterobacterales in Western Europe, North Africa and the Middle East. In contrast to other species, the presence of OXA-48-like in Proteus mirabilis leads to an unusually ...
Janko Sattler, Janina Noster, Yvonne Stelzer, Martina Spille, Sina Schäfer, Kyriaki Xanthopoulou, Julian Sommer, Jonathan Jantsch, Silke Peter, Stephan Göttig, Sören G. Gatermann, Axel Hamprecht   +11 more
doaj   +6 more sources

One-Step Differential Detection of OXA-48-Like Variants Using High-Resolution Melting (HRM) Analysis [PDF]

Antibiotics, 2020
OXA-48-like carbapenemase gene remains a hidden threat, as different OXA-48 variants have varying presentations of susceptibility to antibiotics that might affect the treatment decisions.
Min Yi Lau, Kartini Abdul Jabar, Kek Heng Chua, Boon Pin Kee, Sasheela Sri La Sri Ponnampalavanar, Chun Wie Chong, Cindy Shuan Ju Teh   +6 more
doaj   +5 more sources

Recombinase Polymerase Amplification Combined with Lateral Flow Strip for Rapid Detection of OXA-48-like Carbapenemase Genes in Enterobacterales [PDF]

Antibiotics, 2022
Carbapenem-resistant Enterobacterales (CRE) possessing various carbapenemases, particularly the OXA-48 group, are now rapidly spreading and becoming a major public health concern worldwide.
Phatsarawadee Hemwaranon, Arpasiri Srisrattakarn, Aroonlug Lulitanond, Patcharaporn Tippayawat, Ratree Tavichakorntrakool, Lumyai Wonglakorn, Jureerut Daduang, Aroonwadee Chanawong   +7 more
doaj   +2 more sources

Emergence of OXA-48-like Carbapenemase-Producing Escherichia coli in Baranya County, Hungary [PDF]

Antibiotics
Background: Carbapenem-resistant Escherichia coli (CREC) producing OXA-48-like carbapenemase was first detected in Hungary in 2022. The aim of the present study was to characterize such strains isolated in 2022–2025 in Baranya County, Hungary.
Fatma A. Mohamed, Mohamed Al-Bulushi, Szilvia Melegh, Bálint Timmer, Réka Meszéna, Csongor Freytag, Levente Laczkó, László Miló, Péter Urbán, Renáta Bőkényné-Tóth, Attila Gyenesei, Gábor Kardos, Adrienn Nyul, Edit Urbán, Tibor Pál, Ágnes Sonnevend   +15 more
doaj   +2 more sources

High prevalence of OXA-48-like and NDM carbapenemases among carbapenem resistant Klebsiella pneumoniae of clinical origin from Iran [PDF]

Iranian Journal of Microbiology, 2023
Background and Objectives: Klebsiella pneumoniae is increasingly developing resistance to last-resort antibiotics such as carbapenems. This study aimed to investigate the dissemination of common carbapenemase encoding genes among 48 clinical isolates of
Fatemeh Ghanbarinasab, Mehri Haeili, Somayeh Nasiri Ghanati, Mohaddeseh Moghimi   +3 more
doaj   +2 more sources

Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases [PDF]

Scientific Reports, 2022
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems was identified.
Vendula Studentova, Vendula Sudova, Ibrahim Bitar, Veronika Paskova, Jiri Moravec, Petr Pompach, Michael Volny, Petr Novak, Jaroslav Hrabak   +8 more
doaj   +2 more sources

In vitro activity of ceftazidime–avibactam and comparators against OXA-48-like Enterobacterales collected between 2016 and 2020 [PDF]

Microbiology Spectrum
Oxacillinases (OXA)-48-like β-lactamases are one of the most common resistance determinants among carbapenem-resistant Enterobacterales reported globally. Moreover, there is no standard treatment available against organisms producing OXA-48-like enzymes,
Gregory Stone, Mark Wise, Eric Utt
doaj   +2 more sources