Mechanistic Basis of OXA-48-like β-Lactamases’ Hydrolysis of Carbapenems [PDF]
ACS Infectious Diseases, 2021 Carbapenem-hydrolyzing class D β-lactamases (CHDLs) are an important source of resistance to these last resort β-lactam antibiotics. OXA-48 is a member of a group of CHDLs named OXA-48-like enzymes. On the basis of sequence similarity, OXA-163 can be classified as an OXA-48-like enzyme, but it has altered substrate specificity.
Liya Hu, Banumathi Sankaran, Feng Wang
exaly +6 more sources
OXA-48-Like β-Lactamases: Global Epidemiology, Treatment Options, and Development Pipeline [PDF]
Antimicrobial Agents and Chemotherapy, 2022 Modern medicine is threatened by the rising tide of antimicrobial resistance, especially among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β-lactamases. The penicillin and cephalosporin ascendancies were, in their turn, ended by the proliferation of TEM penicillinases and CTX-M extended-spectrum β-lactamases.
Sara Elizabeth Boyd +2 more
exaly +6 more sources
OXA-48-Like-Producing Klebsiella pneumoniae in Southern Spain in 2014–2015 [PDF]
Antimicrobial Agents and Chemotherapy, 2019 The aim of this study was to characterize the population structure of 56 OXA-48-like-producing Klebsiella pneumoniae isolates, as well as extended-spectrum β-lactamase (ESBL) and carbapenemase genes, recovered in 2014 and 2015 from 16 hospitals in southern Spain.
Jesús Machuca +2 more
exaly +9 more sources
Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]
Journal of Antimicrobial Chemotherapy, 2015 Objectives: Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum ...
Nordmann, Patrice +2 more
core +6 more sources
Phenotypic and Genotypic Features of Klebsiella pneumoniae Harboring Carbapenemases in Egypt: OXA-48-Like Carbapenemases as an Investigated Model [PDF]
Antibiotics, 2020 This study aimed at the characterization of carbapenem-resistant Klebsiella pneumoniae isolates focusing on typing of the blaOXA-48-like genes. Additionally, the correlation between the resistance pattern and biofilm formation capacity of the carbapenem ...
Suzan Mohammed Ragheb +3 more
doaj +2 more sources
Emergence and Spread of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae [PDF]
Korean Journal of Nosocomial Infection Control, 2015 Since 2001, ten more OXA-48 variants have been identified. Shewanella spp. has been thought to be the original host for OXA-48-like enzymes. These enzymes strongly hydrolyze penicillins and weakly hydrolyze carbapenems, with very weak activity against ...
이경원, 정석훈
core +2 more sources
Journal of Global Antimicrobial Resistance, 2020 Objectives: The aim of this study was to elucidate the molecular features of genes, plasmids and clones of OXA-48-like producingKlebsiella pneumoniae isolates recovered in Sahloul Hospital (Sousse, Tunisia) in the period 2012–2014.
Aziza Messaoudi +8 more
doaj +3 more sources
Limits of rapid diagnostics: genomic and structural insights into OXA-48–like mediated carbapenem resistance in Escherichia coli [PDF]
Frontiers in MicrobiologyCarbapenem-resistant Escherichia coli (CREC) represent a major clinical threat because of limited treatment options and frequent multidrug resistance.
Aya A. Diab +13 more
doaj +2 more sources
In-Vitro Selection of Ceftazidime/Avibactam Resistance in OXA-48-Like-Expressing Klebsiella pneumoniae: In-Vitro and In-Vivo Fitness, Genetic Basis and Activities of β-Lactam Plus Novel β-Lactamase Inhibitor or β-Lactam Enhancer Combinations [PDF]
Antibiotics, 2021 Ceftazidime/avibactam uniquely demonstrates activity against both KPC and OXA-48-like carbapenemase-expressing Enterobacterales. Clinical resistance to ceftazidime/avibactam in KPC-producers was foreseen in in-vitro resistance studies.
Snehal Palwe +5 more
doaj +2 more sources
OXA-48-like carbapenemases in the UK: an analysis of isolates and cases from 2007 to 2014 [PDF]
Journal of Antimicrobial Chemotherapy, 2017 Objectives: OXA-48-like carbapenemases have spread worldwide since 2001. We analysed patient and microbiological data for UK isolates with these enzymes as confirmed by the national reference laboratory from November 2007 - December 2014.
Doumith, Michel +9 more
core +6 more sources