Results 31 to 40 of about 52,257,618 (175)

To Be or Not to Be an OXA-48 Carbapenemase

Microorganisms, 2022
Since the first description of OXA-48, more than forty variants have been recovered from Enterobacterales isolates. Whereas some OXA-48-related enzymes have been reported as conferring similar resistance patterns, namely, the hydrolysis of carbapenems ...
Laura Dabos, Saoussen Oueslati, Sandrine Bernabeu, Rémy A. Bonnin, Laurent Dortet, Thierry Naas   +5 more
doaj   +2 more sources

Phenotypic and Genotypic Features of Klebsiella pneumoniae Harboring Carbapenemases in Egypt: OXA-48-Like Carbapenemases as an Investigated Model [PDF]

Antibiotics, 2020
This study aimed at the characterization of carbapenem-resistant Klebsiella pneumoniae isolates focusing on typing of the blaOXA-48-like genes. Additionally, the correlation between the resistance pattern and biofilm formation capacity of the carbapenem ...
Suzan Mohammed Ragheb, Mahmoud Mohamed Tawfick, Amani Ali El-Kholy, Abeer Khairy Abdulall   +3 more
doaj   +2 more sources

Limits of rapid diagnostics: genomic and structural insights into OXA-48–like mediated carbapenem resistance in Escherichia coli [PDF]

Frontiers in Microbiology
Carbapenem-resistant Escherichia coli (CREC) represent a major clinical threat because of limited treatment options and frequent multidrug resistance.
Aya A. Diab, Deena Jalal, Youssef M. Fadel, Omar Samir, Lobna Shalaby, Lobna Shalaby, Mervat Elanany, Mervat Elanany, Sabah A. Abo-Elmaaty, Ramy K. Aziz, Ramy K. Aziz, Ahmed AbdelAziz Sayed, Ahmed AbdelAziz Sayed, Mervat G. Hassan   +13 more
doaj   +2 more sources

In-Vitro Selection of Ceftazidime/Avibactam Resistance in OXA-48-Like-Expressing Klebsiella pneumoniae: In-Vitro and In-Vivo Fitness, Genetic Basis and Activities of β-Lactam Plus Novel β-Lactamase Inhibitor or β-Lactam Enhancer Combinations [PDF]

Antibiotics, 2021
Ceftazidime/avibactam uniquely demonstrates activity against both KPC and OXA-48-like carbapenemase-expressing Enterobacterales. Clinical resistance to ceftazidime/avibactam in KPC-producers was foreseen in in-vitro resistance studies.
Snehal Palwe, Yamuna Devi Bakthavatchalam, Kshama Khobragadea, Arun S. Kharat, Kamini Walia, Balaji Veeraraghavan   +5 more
doaj   +2 more sources

Characterisation of OXA-244, a chromosomally-encoded OXA-48-like β-lactamase from Escherichia coli [PDF]

International Journal of Antimicrobial Agents, 2015
International audienceABSTRACT Shewanella spp. constitute a reservoir of antibiotic resistance determinants. In a bile sample, we identified three extended-spectrum-β-lactamase (ESBL)-producing bacteria ( Escherichia coli , Klebsiella pneumoniae , and ...
Dortet, Laurent, Potron, Anaïs, Nordmann, Patrice, Poirel, Laurent, Potron A, Dortet L, Nordmann P, Poirel L   +7 more
core   +5 more sources

Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, severely challenge treatment of multi-drug resistant bacterial infections. OXA-48 is among the most widely disseminated carbapenemases in Enterobacterales, consequently new treatment ...
Hoff JF, Goudar KE, Beer M, Hinchliffe P, Shaw JM, Tooke CL, Takebayashi Y, Mulholland AJ, Schofield CJ, Spencer J.   +9 more
europepmc   +3 more sources

Carbapenem-Resistant NDM and OXA-48-like Producing K. pneumoniae: From Menacing Superbug to a Mundane Bacteria; A Retrospective Study in a Romanian Tertiary Hospital [PDF]

Antibiotics
Background: Carbapenem-resistant Klebsiella pneumoniae (Cr-Kpn) is becoming a growing public health problem through the failure of adequate treatment.
Dragos Stefan Lazar, Maria Nica, Amalia Dascalu, Corina Oprisan, Oana Albu, Daniel Romeo Codreanu, Alma Gabriela Kosa, Corneliu Petru Popescu, Simin Aysel Florescu   +8 more
doaj   +2 more sources

Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436. [PDF]

Acta Crystallogr F Struct Biol Commun, 2021
The crystal structure of the class D β-lactamase OXA-436 was solved to a resolution of 1.80 Å. Higher catalytic rates were found at higher temperatures for the clinically important antibiotic imipenem, indicating better adaptation of OXA-436 to its mesophilic host than OXA-48, which is believed to originate from an environmental source.
Lund BA, Thomassen AM, Carlsen TJW, Leiros HKS.   +3 more
europepmc   +5 more sources

Predominant Distribution of OXA-48-Like Carbapenemase in Fecal Colonization. [PDF]

Antimicrob Agents Chemother, 2020
Yuan WL, Xu JL, Guo L, Deng QF, Deng DY.
europepmc   +4 more sources

OXA-48-like carbapenemases: the phantom menace [PDF]

Journal of Antimicrobial Chemotherapy, 2012
OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly reported in enterobacterial species. To date, six OXA-48-like variants have been identified, with OXA-48 being the most widespread. They differ by a few amino acid substitutions or deletions (one to five amino acids).
Laurent, Poirel, Anaïs, Potron, Patrice, Nordmann   +2 more
openaire   +2 more sources