Results 21 to 30 of about 17,417 (187)

Characterisation of OXA-244, a chromosomally-encoded OXA-48-like β-lactamase from Escherichia coli [PDF]

International Journal of Antimicrobial Agents, 2016
International audienceABSTRACT Shewanella spp. constitute a reservoir of antibiotic resistance determinants. In a bile sample, we identified three extended-spectrum-β-lactamase (ESBL)-producing bacteria ( Escherichia coli , Klebsiella pneumoniae , and ...
Dortet, Laurent, Nordmann, Patrice, Poirel, Laurent, Potron, Anaïs   +3 more
core   +6 more sources

Evaluation of the Immunochromatographic NG-Test Carba 5, RESIST-5 O.O.K.N.V., and IMP K-SeT for Rapid Detection of KPC-, NDM-, IMP-, VIM-type, and OXA-48-like Carbapenemase Among Enterobacterales [PDF]

Frontiers in Microbiology, 2021
BackgroundEnterobacterales are the most common pathogens for nosocomial infections. The emergence and spread of KPC, NDM, and OXA-48-like carbapenemase-producing Enterobacterales with their extensively drug-resistant characteristics have posed great ...
Renru Han, Renru Han, Yan Guo, Yan Guo, Mingjia Peng, Mingjia Peng, Qingyu Shi, Qingyu Shi, Shi Wu, Shi Wu, Yang Yang, Yang Yang, Yonggui Zheng, Yonggui Zheng, Dandan Yin, Dandan Yin, Fupin Hu, Fupin Hu   +17 more
doaj   +2 more sources

Carbapenem-Resistant NDM and OXA-48-like Producing K. pneumoniae: From Menacing Superbug to a Mundane Bacteria; A Retrospective Study in a Romanian Tertiary Hospital [PDF]

Antibiotics
Background: Carbapenem-resistant Klebsiella pneumoniae (Cr-Kpn) is becoming a growing public health problem through the failure of adequate treatment.
Dragos Stefan Lazar, Maria Nica, Amalia Dascalu, Corina Oprisan, Oana Albu, Daniel Romeo Codreanu, Alma Gabriela Kosa, Corneliu Petru Popescu, Simin Aysel Florescu   +8 more
doaj   +2 more sources

Detection of OXA-48-like and NDM carbapenemases producing Klebsiella pneumoniae in Jordan: A pilot study

Journal of Infection and Public Health, 2017
Summary: Little is known of carbapenemase producing Klebsiella pneumoniae (CPK) in Jordan. This study aimed to determine the prevalence of CPK in a major hospital in Amman, Jordan in 2012–2013 and to characterize the isolates and detect the types of ...
Amin A. Aqel, Panagiota Giakkoupi, Hamed Alzoubi, Ibrahim Masalha, Matthew J. Ellington, Alkiviadis Vatopoulos   +5 more
doaj   +3 more sources

Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436. [PDF]

Acta Crystallogr F Struct Biol Commun, 2021
The crystal structure of the class D β-lactamase OXA-436 was solved to a resolution of 1.80 Å. Higher catalytic rates were found at higher temperatures for the clinically important antibiotic imipenem, indicating better adaptation of OXA-436 to its mesophilic host than OXA-48, which is believed to originate from an environmental source.
Lund BA, Thomassen AM, Carlsen TJW, Leiros HKS.   +3 more
europepmc   +5 more sources

Predominant Distribution of OXA-48-Like Carbapenemase in Fecal Colonization. [PDF]

Antimicrob Agents Chemother, 2020
Yuan WL, Xu JL, Guo L, Deng QF, Deng DY.
europepmc   +4 more sources

First Isolates of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae in A Specialized Cancer Center. [PDF]

Infect Chemother, 2022
OXA-48-like carbapenemases have been found in a growing and varied number of carbapenemase-producing Enterobacteriaceae (CPE) isolates, and they are spreading to several countries. Although this oxacillinase leads to weak resistance to carbapenems without affecting broad-spectrum cephalosporin activity, when they are associated with other resistance ...
Villanueva-Cotrina F, Condori DM, Gomez TO, Yactayo KM, Barron-Pastor H.   +4 more
europepmc   +3 more sources

Emergence of OXA-48-like producing Citrobacter species, Germany, 2011 to 2022. [PDF]

Euro Surveill
Background Carbapenemase-producing Enterobacterales are a public health threat worldwide and OXA-48 is the most prevalent carbapenemase in Germany and western Europe. However, the molecular epidemiology of OXA-48 in species other than Escherichia coli and Klebsiella pneumoniae remains poorly understood.
Sommer J, Reiter H, Sattler J, Cacace E, Eisfeld J, Gatermann S, Hamprecht A, Göttig S.   +7 more
europepmc   +4 more sources

Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases. [PDF]

RSC Med Chem
The OXA-48 β-lactamase protects bacteria from carbapenem antibiotics; with activity affected by sequence variation. We show variation to affect susceptibility towards diazabicyclooctane (DBO) inhibitors, dependent upon the inhibitor C2 substituent.
Hoff JF, Goudar KE, Calvopiña K, Beer M, Hinchliffe P, Shaw JM, Tooke CL, Takebayashi Y, Cadzow AF, Harmer NJ, Mulholland AJ, Schofield CJ, Spencer J.   +12 more
europepmc   +3 more sources

Characterisation of OXA-48-like carbapenemases in Escherichia coli and Klebsiella pneumoniae from North India. [PDF]

3 Biotech, 2023
The oxacillinase-48 (OXA-48)-like carbapenemases are class D β-lactamases and increasingly reported in Enterobacterial species. The detection of these carbapenemases is challenging and little information is available on the epidemiology and plasmid characteristics of OXA-48-like carbapenemase producers.
Singh S, Pathak A, Fatima N, Sahu C, Prasad KN.   +4 more
europepmc   +3 more sources