Results 21 to 30 of about 52,257,618 (175)

OXA-48-Like β-Lactamases: Global Epidemiology, Treatment Options, and Development Pipeline. [PDF]

Antimicrob Agents Chemother, 2022
Modern medicine is threatened by the rising tide of antimicrobial resistance, especially among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β-lactamases. The penicillin and cephalosporin ascendancies were, in their turn,
Boyd SE, Holmes A, Peck R, Livermore DM, Hope W.   +4 more
europepmc   +5 more sources

Emergence of carbapenem-resistant Klebsiella pneumoniae harbouring bla OXA-48-like genes in China [PDF]

Journal of Medical Microbiology, 2021
Klebsiella pneumoniae strains carrying OXA-48-like carbapenemases are increasingly prevalent across the globe. There is thus an urgent need to better understand the mechanisms that underpin the dissemination of bla OXA-48-like carbapenemases. To this end,
Yan, Rushuang, Fu, Ying, Moran, Robert A, Fang, Li, Yu, Yunsong, Chen, Ying, Yang, Yunxing, Chen, Yan, Zhao, Dongdong, Hua, Xiaoting, Shen, Ping, Jiang, Yan, van Schaik, Willem; id_orcid, Yunxing Yang, Yunsong Yu, Dongdong Zhao, Yan Chen, Willem van Schaik, Li Fang, Xiaoting Hua, Yan Jiang, Rushuang Yan, Ying Fu, Ping Shen, Ying Chen, Robert A. Moran   +25 more
core   +4 more sources

Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases. [PDF]

RSC Med Chem
Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, challenge the treatment of multi-drug resistant bacteria. The OXA-48 carbapenemase is widely disseminated in Enterobacterales, necessitating new treatments for producer strains ...
Hoff JF, Goudar KE, Calvopiña K, Beer M, Hinchliffe P, Shaw JM, Tooke CL, Takebayashi Y, Cadzow AF, Harmer NJ, Mulholland AJ, Schofield CJ, Spencer J.   +12 more
europepmc   +5 more sources

Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases [PDF]

Scientific Reports, 2022
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems was identified.
Vendula Studentova, Vendula Sudova, Ibrahim Bitar, Veronika Paskova, Jiri Moravec, Petr Pompach, Michael Volny, Petr Novak, Jaroslav Hrabak   +8 more
doaj   +2 more sources

In vitro activity of ceftazidime–avibactam and comparators against OXA-48-like Enterobacterales collected between 2016 and 2020 [PDF]

Microbiology Spectrum
Oxacillinases (OXA)-48-like β-lactamases are one of the most common resistance determinants among carbapenem-resistant Enterobacterales reported globally. Moreover, there is no standard treatment available against organisms producing OXA-48-like enzymes,
Gregory Stone, Mark Wise, Eric Utt
doaj   +2 more sources

Spatiotemporal genomic analysis and risk assessment of the plasmids carrying bla OXA-48-like genes based on a large-scale international dataset [PDF]

BMC Microbiology
Background The spread of OXA-48-like carbapenemases represents a major public health challenge. Although previous studies have investigated OXA-48-like carbapenemases risk factors, nosocomial dissemination, and plasmid dynamics, an integrated plasmid ...
Qiheng Yuan, Junlin Wang, Xiaowei Liu, Xumeng Yu, Jiatao Li, Du Guo, Qinru Jing, Yongliang Lou, Yutong Kang, Meiqin Zheng   +9 more
doaj   +2 more sources

Culture-independent methods reveal high diversity of OXA-48-like genes in water environments [PDF]

Journal of Water and Health, 2017
The carbapenemase OXA-48 was identified for the first time in 2001 and is now one of the greatest concerns in terms of antibiotic resistance.
Isabel Silva, Marta Tacão, Isabel Henriques   +2 more
core   +3 more sources

A greater than expected variability among OXA-48-like carbapenemases

, 2018
International audienceBackground: OXA-48-like carbapenemases represent a major health concern given their difficult detection, their epidemic behavior and their propensity to modify their spectrum of hydrolysis through point mutations.
Zavala, Agustin, Naas, Thierry, Dabos, Maria, Laura, Oueslati, Saoussen, Iorga, Bogdan I.   +4 more
core   +5 more sources

Laboratory detection and clinical implication of oxacillinase-48 like carbapenemase: The hidden threat

Journal of Global Infectious Diseases, 2016
Carbapenemase producing Gram-negative pathogen is of great concern for physician. The challenging aspects are treatment option and infection control.
Yamuna Devi Bakthavatchalam, Shalini Anandan, Balaji Veeraraghavan   +2 more
doaj   +2 more sources

An MLST approach to support tracking of plasmids carrying OXA-48-like carbapenemase. [PDF]

J Antimicrob Chemother, 2019
Objectives The prevalence of infections caused by OXA-48-like carbapenemase-producing organisms in Ireland has increased dramatically since 2011 and is an urgent public health issue.
Brehony C, McGrath E, Brennan W, Tuohy A, Whyte T, Brisse S, Maiden M, Jolley K, Morris D, Cormican M.   +9 more
europepmc   +9 more sources