Results 31 to 40 of about 24,184 (203)

Klebsiella Species and Enterobacter cloacae Isolates Harboring blaOXA-181 and blaOXA-48: Resistome, Fitness Cost, and Plasmid Stability

Microbiology Spectrum, 2022
IncX3 and IncL plasmids have been named as catalysts advancing dissemination of blaOXA-181 and blaOXA-48 genes. However, their impact on the performance of host cells is vastly understudied. Genetic characteristics of blaOXA-48- and blaOXA-181-containing
Samiratu Mahazu, Isaac Prah, Yusuke Ota, Takaya Hayashi, Yoko Nukui, Masato Suzuki, Yoshihiko Hoshino, Yukihiro Akeda, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito   +11 more
doaj   +1 more source

Prospective evaluation of the OXA-48K-SeT assay, an immunochromatographic test for the rapid detection of OXA-48-type carbapenemases [PDF]

Journal of Antimicrobial Chemotherapy, 2016
There is an urgent need for accurate and fast diagnostic tests to identify MDR bacteria. Here, we evaluated an immunochromatographic assay (the OXA-48 K-SeT assay) to detect OXA-48-like carbapenemase-producing Enterobacteriaceae from culture colonies.One hundred and sixty-one collection isolates with characterized β-lactamase content and 185 non ...
Laurent, Dortet, Agnès, Jousset, Vincent, Sainte-Rose, Gaëlle, Cuzon, Thierry, Naas   +4 more
openaire   +2 more sources

Evaluation of an Immunochromatographic Lateral Flow Assay (OXA-48 K -SeT) for Rapid Detection of OXA-48-Like Carbapenemases in Enterobacteriaceae [PDF]

Journal of Clinical Microbiology, 2016
ABSTRACT We evaluated an immunochromatographic lateral flow assay to detect OXA-48-like carbapenemases (OXA-48 K -SeT) in Enterobacteriaceae ( n = 82). One hundred percent sensitivity and specificity were observed using bacteria recovered from both solid ...
Wareham, DW, Shah, R, Betts, JW, Phee, LM, Momin, MHFA   +4 more
openaire   +4 more sources

OXA-181 Beta Lactamase is not a Major Mediator of Carbapenem Resistance in Enterobacteriaceae [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Detection of carbapenem hydrolyzing class D beta lactamase OXA-181, (a variant of OXA-48) in Enterobacteriaceae, is important, to institute appropriate therapy and to initiate preventive measures.
M. Shanthi, Uma Sekar, Arunagiri K., Hemant Goverdhandas Bramhne   +3 more
doaj   +1 more source

Association Between Types of Carbapenemase and Clinical Outcomes of Infection Due to Carbapenem Resistance Enterobacterales

Infection and Drug Resistance, 2022
Korawan Pudpong,1,2 Sutthiporn Pattharachayakul,3 Wichai Santimaleeworagun,4,5 Ozioma F Nwabor,6 Varaporn Laohaprertthisan,7 Thanaporn Hortiwakul,6 Boonsri Charernmak,6 Sarunyou Chusri6 1Department of Pharmacy, College of Pharmacotherapy Thailand ...
Pudpong K, Pattharachayakul S, Santimaleeworagun W, Nwabor NF, Laohaprertthisan V, Hortiwakul T, Charernmak B, Chusri S   +7 more
doaj  

Detection of OXA-181 Carbapenemase in Shigella flexneri

Emerging Infectious Diseases
We report the detection of OXA-181 carbapenemase in an azithromycin-resistant Shigella spp. bacteria in an immunocompromised patient. The emergence of OXA-181 in Shigella spp.
Ghulam Dhabaan, Hassan Jamal, Danielle Ouellette, Sarah Alexander, Karen Arane, Aaron Campigotto, Manal Tadros, Pierre-Philippe Piché-Renaud   +7 more
doaj   +1 more source

Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]

Journal of Antimicrobial Chemotherapy, 2015
Abstract Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Oueslati S, Nordmann P, Poirel L
openaire   +5 more sources

Emergence of OXA-48-Producing Klebsiella pneumoniae in Taiwan

PLOS ONE, 2015
The isolation of OXA-48-producing Enterobacteriaceae has increased dramatically in Mediterranean countries in the past 10 years, and has recently emerged in Asia. Between January 2012 and May 2014, a total of 760 carbapenem non-susceptible Klebsiella pneumoniae (CnSKP) isolates were collected during a Taiwan national surveillance.
Ling Ma, Jann-Tay Wang, Tsu-Lan Wu, L Kristopher Siu, Yin-Ching Chuang, Jung-Chung Lin, Min-Chi Lu, Po-Liang Lu   +7 more
openaire   +4 more sources

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Detection of rare carbapenemases in Enterobacterales—comparison of two colorimetric and three CIM-based carbapenemase assays

Microbiology Spectrum
Rapid and reliable detection of carbapenemase-producing Enterobacterales (CPE) is crucial for prompt treatment and infection control. Most assays target the primary four enzymes (KPC, OXA-48-like, VIM, and NDM), often missing less common variants (e.g ...
Lukas Schaffarczyk, Janina Noster, Yvonne Stelzer, Janko Sattler, Sören Gatermann, Axel Hamprecht   +5 more
doaj   +1 more source