Results 31 to 40 of about 30,220 (240)

Klebsiella Species and Enterobacter cloacae Isolates Harboring blaOXA-181 and blaOXA-48: Resistome, Fitness Cost, and Plasmid Stability

Microbiology Spectrum, 2022
IncX3 and IncL plasmids have been named as catalysts advancing dissemination of blaOXA-181 and blaOXA-48 genes. However, their impact on the performance of host cells is vastly understudied. Genetic characteristics of blaOXA-48- and blaOXA-181-containing
Samiratu Mahazu, Isaac Prah, Yusuke Ota, Takaya Hayashi, Yoko Nukui, Masato Suzuki, Yoshihiko Hoshino, Yukihiro Akeda, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito   +11 more
doaj   +1 more source

Substrate Specificity of OXA-48 after β5−β6 Loop Replacement [PDF]

ACS Infectious Diseases, 2020
OXA-48 carbapenemase has rapidly spread in many countries worldwide with several OXA-48-variants being described, differing by a few amino acid (AA) substitutions or deletions, mostly in the β5-β6 loop. While single AA substitutions have only a minor impact on OXA-48 hydrolytic profiles, others with 4 AA deletions result in loss of carbapenem ...
Laura Dabos, Agustin Zavala, Rémy A. Bonnin, Oliver Beckstein, Pascal Retailleau, Bogdan I. Iorga, Thierry Naas   +6 more
openaire   +2 more sources

Increasing proportion of carbapenemase-producing Enterobacteriaceae and emergence of a MCR-1 producer through a multicentric study among hospital-based and private laboratories in Belgium from September to November 2015 [PDF]

, 2017
Carbapenemase-producing Enterobacteriaceae (CPE) strains have been increasingly reported in Belgium. We aimed to determine the proportion of CPE among Enterobacteriaceae isolated from hospitalised patients and community outpatients in Belgium in 2015 ...
Bauraing, Caroline, Berhin, Catherine, Boelens, Jerina, Bogaerts, Pierre, Claeys, Geert, Glupczynski, Youri, Hoebeke, Martin, Huang, Te Din, multicentre study group, on behalf of a   +8 more
core   +1 more source

OXA-48-like carbapenemases producing Enterobacteriaceae in different niches [PDF]

European Journal of Clinical Microbiology & Infectious Diseases, 2017
The emergence of carbapenem-resistant enterobacterial species poses a serious threat to public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are widely distributed among Enterobacteriaceae, with significant geographical differences.
Assia, Mairi, Alix, Pantel, Albert, Sotto, Jean-Philippe, Lavigne, Aziz, Touati   +4 more
openaire   +2 more sources

OXA-181 Beta Lactamase is not a Major Mediator of Carbapenem Resistance in Enterobacteriaceae [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Detection of carbapenem hydrolyzing class D beta lactamase OXA-181, (a variant of OXA-48) in Enterobacteriaceae, is important, to institute appropriate therapy and to initiate preventive measures.
M. Shanthi, Uma Sekar, Arunagiri K., Hemant Goverdhandas Bramhne   +3 more
doaj   +1 more source

OXA-484, an OXA-48-Type Carbapenem-Hydrolyzing Class D β-Lactamase From Escherichia coli

Frontiers in Microbiology, 2021
OXA-48-like carbapenemases are among the most frequent carbapenemases in Gram-negative Enterobacterales worldwide with the highest prevalence in the Middle East, North Africa and Europe.
Julian Sommer, Kristina M. Gerbracht, Felix F. Krause, Florian Wild, Manuela Tietgen, Manuela Tietgen, Manuela Tietgen, Sara Riedel-Christ, Janko Sattler, Axel Hamprecht, Axel Hamprecht, Volkhard A. J. Kempf, Volkhard A. J. Kempf, Stephan Göttig   +13 more
doaj   +1 more source

Concurrent interspecies and clonal dissemination of OXA-48 carbapenemase [PDF]

Clinical Microbiology and Infection, 2015
Several isolates of four different carbapenemase-producing Enterobacteriaceae species were recovered from a patient hospitalized for 4 months in a teaching hospital in Madrid. These species comprised seven Klebsiella pneumoniae belonging to ST15, four Escherichia coli belonging to ST2531, two Serratia marcescens and one Citrobacter freundii.
Arana, D.M., Saez, D., García-Hierro, P., Bautista, V., Fernández-Romero, S., Ángel de la Cal, M., Alós, J.I., Oteo, J.   +7 more
openaire   +2 more sources

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study. [PDF]

, 2019
Antimicrobial resistance (AMR) poses a threat to public health. Clinical microbiology laboratories typically rely on culturing bacteria for antimicrobial-susceptibility testing (AST).
Aller, SD, Bruchmann, S, Clark, T, Coello Pelegrin, A, Cormican, M, Diez Benavente, E, Doyle, RM, Ellington, MJ, Harris, KA, Huggett, JF, McGrath, E, Moran-Gilad, J, Motro, Y, O'Sullivan, DM, Phelan, J, Phuong Thuy Nguyen, T, Shaw, LP, Stabler, RA, van Belkum, A, van Dorp, L, Woodford, N   +20 more
core   +4 more sources

National survey of colistin resistance among carbapenemase-producing Enterobacteriaceae and outbreak caused by colistin-resistant OXA-48-producing Klebsiella pneumoniae, France, 2014 [PDF]

, 2016
From January 2014 to December 2014, 972 consecutive non-replicate carbapenemase-producing Enterobacteriaceae isolates from colonised or infected patients were collected at the Associated French National Reference Centre as part of the French national ...
Dortet, L, Jayol, A, Nordmann, P, Poirel, L   +3 more
core   +1 more source

Phosphonopeptides Revisited, in an Era of Increasing Antimicrobial Resistance [PDF]

, 2020
Given the increase in resistance to antibacterial agents, there is an urgent need for the development of new agents with novel modes of action. As an interim solution, it is also prudent to reinvestigate old or abandoned antibacterial compounds to assess
Anderson, Rosaleen, Bedernjak, Alexandre F., Cummings, Stephen P., Day, Kathryn M., Gray, Mark, Jones, Amanda L., Marrs, Emma C.L., Perry, John D., Varadi, Linda   +8 more
core   +2 more sources