Results 31 to 40 of about 49,551,276 (233)

Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors

Frontiers in Pharmacology, 2022
Carbapenem resistance in Enterobacteriaceae caused by OXA-48 β-lactamase is a growing global health threat and has rapidly spread in many regions of the world. Developing inhibitors is a promising way to overcome antibiotic resistance. However, there are
Yuejuan Zhang, Yuejuan Zhang, Cheng Chen, Bin Cheng, Lei Gao, Lei Gao, Chuan Qin, Chuan Qin, Lixia Zhang, Xu Zhang, Xu Zhang, Jun Wang, Jun Wang, Yi Wan, Yi Wan   +14 more
doaj   +1 more source

Klebsiella Species and Enterobacter cloacae Isolates Harboring blaOXA-181 and blaOXA-48: Resistome, Fitness Cost, and Plasmid Stability

Microbiology Spectrum, 2022
IncX3 and IncL plasmids have been named as catalysts advancing dissemination of blaOXA-181 and blaOXA-48 genes. However, their impact on the performance of host cells is vastly understudied. Genetic characteristics of blaOXA-48- and blaOXA-181-containing
Samiratu Mahazu, Isaac Prah, Yusuke Ota, Takaya Hayashi, Yoko Nukui, Masato Suzuki, Yoshihiko Hoshino, Yukihiro Akeda, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito   +11 more
doaj   +1 more source

NDM-1 and OXA-48-Like Carbapenemases (OXA-48, OXA-181 and OXA-252) Co-Producing Shewanella xiamenensis from Hospital Wastewater, China

Infection and Drug Resistance, 2022
Yicheng Wen,1,* Xiaofang Xie,1,* Ping Xu,2,* Chengcheng Yang,1 Zhichen Zhu,1 Jie Zhu,1 Jingnan Lv,1 Haifang Zhang,1 Liang Chen,3,4 Hong Du1 1Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou ...
Wen Y, Xie X, Xu P, Yang C, Zhu Z, Zhu J, Lv J, Zhang H, Chen L, Du H   +9 more
doaj  

Concurrent interspecies and clonal dissemination of OXA-48 carbapenemase [PDF]

Clinical Microbiology and Infection, 2015
Several isolates of four different carbapenemase-producing Enterobacteriaceae species were recovered from a patient hospitalized for 4 months in a teaching hospital in Madrid. These species comprised seven Klebsiella pneumoniae belonging to ST15, four Escherichia coli belonging to ST2531, two Serratia marcescens and one Citrobacter freundii.
Arana, D.M., Saez, D., García-Hierro, P., Bautista, V., Fernández-Romero, S., Ángel de la Cal, M., Alós, J.I., Oteo, J.   +7 more
openaire   +2 more sources

Prospective evaluation of the OXA-48K-SeT assay, an immunochromatographic test for the rapid detection of OXA-48-type carbapenemases [PDF]

Journal of Antimicrobial Chemotherapy, 2016
There is an urgent need for accurate and fast diagnostic tests to identify MDR bacteria. Here, we evaluated an immunochromatographic assay (the OXA-48 K-SeT assay) to detect OXA-48-like carbapenemase-producing Enterobacteriaceae from culture colonies.One hundred and sixty-one collection isolates with characterized β-lactamase content and 185 non ...
Laurent, Dortet, Agnès, Jousset, Vincent, Sainte-Rose, Gaëlle, Cuzon, Thierry, Naas   +4 more
openaire   +2 more sources

Cefiderocol Comparative Resistance and Clinical Predictors in CRE-BSI: Data from an OXA-48-Endemic Region with Rising OXA-48/NDM Coproducers. [PDF]

Antibiotics (Basel)
Background/Objectives: Bloodstream infections (BSIs) caused by carbapenem-resistant Enterobacterales (CREs) are a growing public health threat due to limited therapeutic options and high mortality. In Turkey, oxacillinase-48 (OXA-48) producers predominate, while OXA-48/New Delhi metallo-β-lactamase (NDM) co-producers are increasingly detected. Although
Dumlu R, Mert A.
europepmc   +4 more sources

Evaluation of an Immunochromatographic Lateral Flow Assay (OXA-48 K -SeT) for Rapid Detection of OXA-48-Like Carbapenemases in Enterobacteriaceae [PDF]

Journal of Clinical Microbiology, 2016
ABSTRACT We evaluated an immunochromatographic lateral flow assay to detect OXA-48-like carbapenemases (OXA-48 K -SeT) in Enterobacteriaceae ( n = 82). One hundred percent sensitivity and specificity were observed using bacteria recovered from both solid ...
Wareham, DW, Shah, R, Betts, JW, Phee, LM, Momin, MHFA   +4 more
openaire   +4 more sources

Association Between Types of Carbapenemase and Clinical Outcomes of Infection Due to Carbapenem Resistance Enterobacterales

Infection and Drug Resistance, 2022
Korawan Pudpong,1,2 Sutthiporn Pattharachayakul,3 Wichai Santimaleeworagun,4,5 Ozioma F Nwabor,6 Varaporn Laohaprertthisan,7 Thanaporn Hortiwakul,6 Boonsri Charernmak,6 Sarunyou Chusri6 1Department of Pharmacy, College of Pharmacotherapy Thailand ...
Pudpong K, Pattharachayakul S, Santimaleeworagun W, Nwabor NF, Laohaprertthisan V, Hortiwakul T, Charernmak B, Chusri S   +7 more
doaj  

OXA-181 Beta Lactamase is not a Major Mediator of Carbapenem Resistance in Enterobacteriaceae [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Detection of carbapenem hydrolyzing class D beta lactamase OXA-181, (a variant of OXA-48) in Enterobacteriaceae, is important, to institute appropriate therapy and to initiate preventive measures.
M. Shanthi, Uma Sekar, Arunagiri K., Hemant Goverdhandas Bramhne   +3 more
doaj   +1 more source

Detection of OXA-181 Carbapenemase in Shigella flexneri

Emerging Infectious Diseases
We report the detection of OXA-181 carbapenemase in an azithromycin-resistant Shigella spp. bacteria in an immunocompromised patient. The emergence of OXA-181 in Shigella spp.
Ghulam Dhabaan, Hassan Jamal, Danielle Ouellette, Sarah Alexander, Karen Arane, Aaron Campigotto, Manal Tadros, Pierre-Philippe Piché-Renaud   +7 more
doaj   +1 more source