Results 31 to 40 of about 1,076,076 (217)

Clinical outcomes of carbapenem therapy in OXA-48-producing Enterobacterales infections: a French multicentre cohort, systematic review, and meta-analysis. [PDF]

Emerg Microbes Infect
OXA-48–producing Enterobacterales (OXA-48-PE) represent a growing global health threat. Most of OXA-48–PE remain categorized susceptible to carbapenems, which might encourage their use despite uncertain clinical efficacy.
Dortet L, Moreau C, Dinh A, Bonnin RA, Escaut L, Seguret M, Weber L, Figueiredo S, Pilmis B.   +8 more
europepmc   +2 more sources

Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48

, 2021
Despite the advances in β-lactamase inhibitor development, limited options exist for the class D carbapenemase known as OXA-48. OXA-48 is one of the most prevalent carbapenemases in carbapenem-resistant Enterobacteriaceae infections and is not ...
Doris Mia Taylor, Justin Anglin (5953505), Doris Mia Taylor (8623326), Lingfei Wang, B. V. Venkataram Prasad, Lingfei Wang (2803441), Martin M. Matzuk, Justin Anglin, B. V. Venkataram Prasad (8623332), Banumathi Sankaran, Jin Wang, Liya Hu (2851901), Liya Hu, Timothy Palzkill (47788), Banumathi Sankaran (1341699), Timothy Palzkill, Martin M. Matzuk (200210), Jin Wang (29560)   +17 more
core   +1 more source

Characterization of OXA-48-producing Klebsiella oxytoca isolates from a hospital outbreak in Tunisia

Journal of Global Antimicrobial Resistance, 2021
Objective: There is very limited information about OXA-48-producing Klebsiella oxytoca. The aim of this study was to describe the phenotypic and molecular characterization of OXA-48-producing K.
Julia Guzmán-Puche, Rim Jenayeh, María Pérez-Vázquez, Manuel-Causse, Ferjani Asma, Boukadida Jalel, Jesús Oteo-Iglesias, Luis Martínez-Martínez   +7 more
doaj   +1 more source

Predominance of OXA-48 carbapenemase-producing Klebsiella pneumoniae strains in tertiary hospital in Sarajevo, Bosnia and Herzegovina. [PDF]

Biomol Biomed
Klebsiella pneumoniae, a member of the Enterobacteriaceae family, demonstrates an increasing trend of resistance to carbapenems and is a common cause of both hospital- and community-acquired infections.
Dedeić Ljubović A, Granov Đ, Zahirović E, Čamdžić A, Muhić A, Salimović Bešić I.   +5 more
europepmc   +2 more sources

Epidemic spread of OXA-48 beta-lactamase in Croatia [PDF]

Journal of Medical Microbiology, 2018
A dramatic increase in OXA-48 β-lactamase was observed recently not only in large hospital centres, but also in smaller suburban hospital centres in geographic areas bordering Croatia. The aim of the study was to analyse the epidemiology, the mechanisms of antibiotic resistance and the routes of spread of OXA-48 carbapenemase in Croatia.Carbapenemase ...
Bedenić, Branka, Slade, Mia, Starčević, Lidija Žele, Sardelić, Sanda, Vranić-Ladavac, Mirna, Benčić, Ana, Zujić Atalić, Vlasta, Bogdan, Maja, Bubonja-Šonje, Marina, Tomić-Paradžik, Maja, Tot, Tatjana, Lukić-Grlić, Amarela, Drenjančević, Domagoj, Varda-Brkić, Dijana, Bandić-Pavlović, Daniela, Mihaljević, Slobodan, Zarfel, Gernot, Gužvinec, Marija, Conzemius, Rick, Barišić, Ivan, Tambić-Andraševic, Arjana   +20 more
openaire   +5 more sources

Spread of OXA-48-Encoding Plasmid in Turkey and Beyond [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla OXA-48 were identified.
Carrer, Amelie, Poirel, Laurent, Yilmaz, Mesut, Akan, Oezay Arikan, Feriha, Cilli, Cuzon, Gaelle, Matar, Ghassan, Honderlick, Patrick, Nordmann, Patrice   +8 more
openaire   +4 more sources

Multiscale simulations identify origins of differential carbapenem hydrolysis by the OXA-48 β-lactamase

, 2022
OXA-48 β-lactamases are frequently encountered in bacterial infections caused by carbapenem-resistant Gram-negative bacteria. Due to the importance of carbapenems in treatment of healthcare-associated infections, and the increasingly wide dissemination ...
Marc, van der Kamp, Tal, Moshe Weizmann, Adrian, Mulholland, James , Spencer, Viivi, Hirvonen   +4 more
core   +1 more source

Laboratory detection and clinical implication of oxacillinase-48 like carbapenemase: The hidden threat

Journal of Global Infectious Diseases, 2016
Carbapenemase producing Gram-negative pathogen is of great concern for physician. The challenging aspects are treatment option and infection control.
Yamuna Devi Bakthavatchalam, Shalini Anandan, Balaji Veeraraghavan   +2 more
doaj   +1 more source

Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors

Frontiers in Pharmacology, 2022
Carbapenem resistance in Enterobacteriaceae caused by OXA-48 β-lactamase is a growing global health threat and has rapidly spread in many regions of the world. Developing inhibitors is a promising way to overcome antibiotic resistance. However, there are
Yuejuan Zhang, Yuejuan Zhang, Cheng Chen, Bin Cheng, Lei Gao, Lei Gao, Chuan Qin, Chuan Qin, Lixia Zhang, Xu Zhang, Xu Zhang, Jun Wang, Jun Wang, Yi Wan, Yi Wan   +14 more
doaj   +1 more source

Concurrent interspecies and clonal dissemination of OXA-48 carbapenemase [PDF]

Clinical Microbiology and Infection, 2015
Several isolates of four different carbapenemase-producing Enterobacteriaceae species were recovered from a patient hospitalized for 4 months in a teaching hospital in Madrid. These species comprised seven Klebsiella pneumoniae belonging to ST15, four Escherichia coli belonging to ST2531, two Serratia marcescens and one Citrobacter freundii.
Arana, D.M., Saez, D., García-Hierro, P., Bautista, V., Fernández-Romero, S., Ángel de la Cal, M., Alós, J.I., Oteo, J.   +7 more
openaire   +2 more sources