Results 51 to 60 of about 30,220 (240)

Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital [PDF]

, 2016
Background: In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. pneumoniae (
Ardanuy Tisaire, María Carmen, Ayats, Josefina, Cubero, Meritxell, Cuervo Requena, Guillermo, Domínguez Luzón, Ma. Ángeles (María Ángeles), Gallego, Lucía, Liñares Louzao, Josefina, Martí Martí, Sara, Peña Miralles, Carmen, Pujol Rojo, Miquel, Sevillano, Elena, Tubau, Fe   +11 more
core   +1 more source

OXA-48-like carbapenemases in the UK: an analysis of isolates and cases from 2007 to 2014 [PDF]

, 2017
Objectives: OXA-48-like carbapenemases have spread worldwide since 2001. We analysed patient and microbiological data for UK isolates with these enzymes as confirmed by the national reference laboratory from November 2007 - December 2014.
Doumith, Michel, Findlay, Jacqueline, Hill, Robert, Hopkins, Katie L, Livermore, David M., Loy, Richard, Meunier, Danièle, Mustafa, Nazim, Pike, Rachel, Woodford, Neil   +9 more
core   +1 more source

Spread of OXA-48-Encoding Plasmid in Turkey and Beyond [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla OXA-48 were identified.
Carrer, Amelie, Poirel, Laurent, Yilmaz, Mesut, Akan, Oezay Arikan, Feriha, Cilli, Cuzon, Gaelle, Matar, Ghassan, Honderlick, Patrick, Nordmann, Patrice   +8 more
openaire   +2 more sources

Detection of rare carbapenemases in Enterobacterales—comparison of two colorimetric and three CIM-based carbapenemase assays

Microbiology Spectrum
Rapid and reliable detection of carbapenemase-producing Enterobacterales (CPE) is crucial for prompt treatment and infection control. Most assays target the primary four enzymes (KPC, OXA-48-like, VIM, and NDM), often missing less common variants (e.g ...
Lukas Schaffarczyk, Janina Noster, Yvonne Stelzer, Janko Sattler, Sören Gatermann, Axel Hamprecht   +5 more
doaj   +1 more source

β‐Triketone‐Based Ionizable Cationic Lipids Synthesized via Click Chemistry for siRNA Delivery

Advanced Science, EarlyView.
This study innovatively applies β‐triketone‐based click chemistry in the synthesis of ionizable cationic lipids (ICLs), which allows the generation of a lipid library in large quantities and in a short time. The ICLs identified achieved effective lipid nanoparticles‐mediated hepatic gene silencing in vivo using siRNA, and computational simulations are ...
Huatian Li, Haocheng Tang, Yiqing Mu, Shangyu Chen, Paul Edward Floreancig, Junmei Wang, Yixian Huang, Song Li   +7 more
wiley   +1 more source

Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae. [PDF]

, 2018
Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of studies to evaluate in vivo the efficacy of combinations therapies.
Cebrero Cangueiro, Tania, Conejo Gonzalo, Mª Carmen, Díaz, Caridad, Labrador Herrera, Gema, Pachón Ibáñez, María Eugenia, Pascual Hernández, Álvaro   +5 more
core   +1 more source

Dynamics and molecular features of OXA-48-like-producing Klebsiella pneumoniae lineages in a Tunisian hospital

Journal of Global Antimicrobial Resistance, 2020
Objectives: The aim of this study was to elucidate the molecular features of genes, plasmids and clones of OXA-48-like producingKlebsiella pneumoniae isolates recovered in Sahloul Hospital (Sousse, Tunisia) in the period 2012–2014.
Aziza Messaoudi, Marisa Haenni, Olfa Bouallègue, Estelle Saras, Pierre Chatre, Cherifa Chaouch, Noureddine Boujâafar, Wejdene Mansour, Jean-Yves Madec   +8 more
doaj   +1 more source

Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48- and NDM-Producing Escherichia coli and Klebsiella pneumoniae

Antibiotics, 2022
Double-carbapenem combinations have shown synergistic potential against carbapenemase-producing Enterobacterales, but data remain inconclusive. This study evaluated the activity of double-carbapenem combinations against 51 clinical KPC-2-, OXA-48-, NDM-1,
Lisa Allander, Karin Vickberg, Pernilla Lagerbäck, Linus Sandegren, Thomas Tängdén   +4 more
doaj   +1 more source

Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]

, 2017
Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Nordmann, Patrice, Oueslati, Saoussen, Poirel, Laurent   +2 more
core  

Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food [PDF]

, 2018
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Fernández, J., Guerra, B., Rodicio Rodicio, María del Rosario   +2 more
core   +3 more sources