Results 41 to 50 of about 1,076,076 (217)

Prospective evaluation of the OXA-48K-SeT assay, an immunochromatographic test for the rapid detection of OXA-48-type carbapenemases [PDF]

Journal of Antimicrobial Chemotherapy, 2016
There is an urgent need for accurate and fast diagnostic tests to identify MDR bacteria. Here, we evaluated an immunochromatographic assay (the OXA-48 K-SeT assay) to detect OXA-48-like carbapenemase-producing Enterobacteriaceae from culture colonies.One hundred and sixty-one collection isolates with characterized β-lactamase content and 185 non ...
Laurent, Dortet, Agnès, Jousset, Vincent, Sainte-Rose, Gaëlle, Cuzon, Thierry, Naas   +4 more
openaire   +2 more sources

NDM-1 and OXA-48-Like Carbapenemases (OXA-48, OXA-181 and OXA-252) Co-Producing Shewanella xiamenensis from Hospital Wastewater, China

Infection and Drug Resistance, 2022
Yicheng Wen,1,* Xiaofang Xie,1,* Ping Xu,2,* Chengcheng Yang,1 Zhichen Zhu,1 Jie Zhu,1 Jingnan Lv,1 Haifang Zhang,1 Liang Chen,3,4 Hong Du1 1Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou ...
Wen Y, Xie X, Xu P, Yang C, Zhu Z, Zhu J, Lv J, Zhang H, Chen L, Du H   +9 more
doaj  

Klebsiella Species and Enterobacter cloacae Isolates Harboring blaOXA-181 and blaOXA-48: Resistome, Fitness Cost, and Plasmid Stability

Microbiology Spectrum, 2022
IncX3 and IncL plasmids have been named as catalysts advancing dissemination of blaOXA-181 and blaOXA-48 genes. However, their impact on the performance of host cells is vastly understudied. Genetic characteristics of blaOXA-48- and blaOXA-181-containing
Samiratu Mahazu, Isaac Prah, Yusuke Ota, Takaya Hayashi, Yoko Nukui, Masato Suzuki, Yoshihiko Hoshino, Yukihiro Akeda, Toshihiko Suzuki, Tomoko Ishino, Anthony Ablordey, Ryoichi Saito   +11 more
doaj   +1 more source

Evaluation of an Immunochromatographic Lateral Flow Assay (OXA-48 K -SeT) for Rapid Detection of OXA-48-Like Carbapenemases in Enterobacteriaceae [PDF]

Journal of Clinical Microbiology, 2016
ABSTRACT We evaluated an immunochromatographic lateral flow assay to detect OXA-48-like carbapenemases (OXA-48 K -SeT) in Enterobacteriaceae ( n = 82). One hundred percent sensitivity and specificity were observed using bacteria recovered from both solid ...
Wareham, DW, Shah, R, Betts, JW, Phee, LM, Momin, MHFA   +4 more
openaire   +4 more sources

Reenvisioning the De Mayo Reaction: A Boron‐Enabled Cycloaddition Approach

Angewandte Chemie, EarlyView.
An oxa‐boracycle conformational lock strategy enables photocatalytic [2+2] cycloaddition to afford densely substituted cyclobutylboronates. The conformational constraint suppresses triplet relaxation and promotes productive bimolecular reactivity.
Neetu Sharma, Yanyao Liu, Partha Sarathi Hazra, Evan B. Piper, Ryan Van Hoveln, Michael Kevin Brown   +5 more
wiley   +2 more sources

Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters

Angewandte Chemie, EarlyView.
A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter, Cameron J. MacRae, Haoran Xiong, Daniel Rozsar, Katherine F. P. Clarke, Darren J. Dixon   +5 more
wiley   +2 more sources

Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases

, 2020
β-lactamase mediated antibiotic resistance threatens treatment of bacterial infections. OXA-48 enzymes are clinically important class D serine β-lactamases (SBLs) that confer resistance to most β-lactam antibiotics, including carbapenems. However, OXA-48
Adrian, Mulholland, Viivi H. A., Hirvonen, Marc W. van der, Kamp, James, Spencer   +3 more
core   +1 more source

OXA-181 Beta Lactamase is not a Major Mediator of Carbapenem Resistance in Enterobacteriaceae [PDF]

Journal of Clinical and Diagnostic Research, 2013
Background: Detection of carbapenem hydrolyzing class D beta lactamase OXA-181, (a variant of OXA-48) in Enterobacteriaceae, is important, to institute appropriate therapy and to initiate preventive measures.
M. Shanthi, Uma Sekar, Arunagiri K., Hemant Goverdhandas Bramhne   +3 more
doaj   +1 more source

Novel Non‐Cytotoxic Acylphosphinates and Acylphosphine Oxides Photoinitiators

Angewandte Chemie, EarlyView.
Novel acylphosphine oxide (APO) and acylphosphinate photoinitiators based on DPO and DOPO were designed to investigate structure–property relationships including photochemical performance, polymerization efficiency and cytotoxicity. While DPO derivatives showed excellent reactivity, DOPO‐based systems also displayed good efficiency and significantly ...
Jiansong Yin, Yijun Zhang, Bernadette Graff, Céline Dietlin, Michael Schmitt, Fabrice Morlet‐Savary, Tatiana Petithory, Laurent Pieuchot, Jing Zhang, Xiaotong Peng, Yangyang Xu, Jean‐Michel Becht, Pu Xiao, Jacques Lalevée   +13 more
wiley   +2 more sources

Association Between Types of Carbapenemase and Clinical Outcomes of Infection Due to Carbapenem Resistance Enterobacterales

Infection and Drug Resistance, 2022
Korawan Pudpong,1,2 Sutthiporn Pattharachayakul,3 Wichai Santimaleeworagun,4,5 Ozioma F Nwabor,6 Varaporn Laohaprertthisan,7 Thanaporn Hortiwakul,6 Boonsri Charernmak,6 Sarunyou Chusri6 1Department of Pharmacy, College of Pharmacotherapy Thailand ...
Pudpong K, Pattharachayakul S, Santimaleeworagun W, Nwabor NF, Laohaprertthisan V, Hortiwakul T, Charernmak B, Chusri S   +7 more
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