Treatment of Infections by OXA-48-Producing Enterobacteriaceae [PDF]
Antimicrobial Agents and Chemotherapy, 2018 Carbapenemase-producing Enterobacteriaceae (CPE) contribute significantly to the global public health threat of antimicrobial resistance. OXA-48 and its variants are unique carbapenemases with low-level hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins.
Adam Stewart +3 more
openaire +3 more sources
Evaluation of a New Phenotypic OXA-48 Disk Test for Differentiation of OXA-48 Carbapenemase-Producing Enterobacteriaceae Clinical Isolates [PDF]
Journal of Clinical Microbiology, 2015 ABSTRACT The current phenotypic methods for detecting carbapenemase-producing Enterobacteriaceae (CPE) allow differentiation between class A and B carbapenemases, but they cannot confirm in a single test class D OXA-48 carbapenemase producers.
Tsakris, A. +5 more
openaire +3 more sources
Journal of Global Infectious Diseases, 2016 Carbapenemase producing Gram-negative pathogen is of great concern for physician. The challenging aspects are treatment option and infection control.
Yamuna Devi Bakthavatchalam +2 more
doaj +1 more source
One-Step Differential Detection of OXA-48-Like Variants Using High-Resolution Melting (HRM) Analysis
Antibiotics, 2020 OXA-48-like carbapenemase gene remains a hidden threat, as different OXA-48 variants have varying presentations of susceptibility to antibiotics that might affect the treatment decisions.
Min Yi Lau +6 more
doaj +1 more source
Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors
Frontiers in Pharmacology, 2022 Carbapenem resistance in Enterobacteriaceae caused by OXA-48 β-lactamase is a growing global health threat and has rapidly spread in many regions of the world. Developing inhibitors is a promising way to overcome antibiotic resistance. However, there are
Yuejuan Zhang +14 more
doaj +1 more source
Structural basis for different substrate profiles of two closely related class D β-lactamases and their inhibition by halogens [PDF]
, 2015 OXA-163 and OXA-48 are closely related class D β-lactamases that exhibit different substrate profiles. OXA-163 hydrolyzes oxyimino-cephalosporins, particularly ceftazidime, while OXA-48 prefers carbapenem substrates.
Chow, Dar-Chone +8 more
core +1 more source
OXA-48-Producing Enterobacteriaceae Causing Bacteremia, United Arab Emirates [PDF]
International Journal of Infectious Diseases, 2015 OXA-48-producing isolates were identified in approximately 4% and less than 1% of ESBL-producing and non-ESBL-producing E. coli and K. pneumoniae causing bacteremia at the largest tertiary hospital in Abu Dhabi.
Chulsoo Ahn +7 more
openaire +3 more sources
Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014. [PDF]
, 2016 In 2014, a total of 2,976 Enterobacteriaceae isolates with decreased susceptibility to carbapenems were received at the French Associated National Reference Center for Antibiotic Resistance (NRC) and were characterised for their molecular resistance ...
Cuzon, G. +3 more
core +1 more source
Genetic and biochemical characterization of OXA-405, an OXA-48-Type extended-spectrum β-lactamase without significant carbapenemase activity [PDF]
, 2015 The epidemiology of carbapenemases worldwide is showing that OXA-48 variants are becoming the predominant carbapenemase type in Enterobacteriaceae in many countries.
Dortet, Laurent +5 more
core +1 more source
OXA-163-producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010. [PDF]
, 2012 Two genetically unrelated OXA-163-carrying Klebsiella pneumoniae strains were identified from two infection cases in June 2009 and May 2010 in Cairo, Egypt. OXA-163-producing Enterobacteriaceae had been previously reported in Argentina only.
Abdelaziz, M. +5 more
core +1 more source