Results 21 to 30 of about 49,551,276 (233)

Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness [PDF]

Frontiers in Microbiology, 2019
OXA-48 is the most common carbapenemase in Enterobacterales in Germany and one of the most frequent carbapenemases worldwide. Several reports have associated blaOXA–48 with a virulent host phenotype.
Axel Hamprecht, Julian Sommer, Matthias Willmann, Christina Brender, Yvonne Stelzer, Felix F. Krause, Tsvetan Tsvetkov, Florian Wild, Sara Riedel-Christ, Julia Kutschenreuter, Can Imirzalioglu, Aitor Gonzaga, Ulrich Nübel, Ulrich Nübel, Stephan Göttig   +14 more
doaj   +4 more sources

Arising Prevalence of OXA-48 producer Escherichia coli and OXA-48 with NDM co-producer Klebsiella pneumoniae Strains [PDF]

Romanian Journal of Laboratory Medicine, 2019
Background/aim: This prospective study aimed to determine the presence of the most common carbapenemase genes, blaOXA-48, blaKPC, blaIMP, blaVIM and blaNDM on carbapenem resistant clinical K.pneumoniae and E.coli isolates. Materials and methods: Isolates
Uskudar-Guclu Aylin, Guney Mustafa, Sig Ali Korhan, Kilic Selcuk, Baysallar Mehmet   +4 more
doaj   +3 more sources

Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020. [PDF]

, 2022
OXA-48-type ß-lactamases are the most prevalent carbapenemase-type in Enterobacterales in Switzerland, predominantly found in Escherichia coli and Klebsiella pneumoniae.
Poirel, L., Nordmann, P., Perreten, V., Findlay, Jacqueline, Findlay, J., Perreten, Vincent, Nordmann, Patrice, Poirel, Laurent   +7 more
core   +3 more sources

Treatment of Infections by OXA-48-Producing Enterobacteriaceae [PDF]

Antimicrobial Agents and Chemotherapy, 2018
Carbapenemase-producing Enterobacteriaceae (CPE) contribute significantly to the global public health threat of antimicrobial resistance. OXA-48 and its variants are unique carbapenemases with low-level hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins.
Adam Stewart, Patrick Harris, Andrew Henderson, David Paterson   +3 more
openaire   +5 more sources

Multiscale simulations identify origins of differential carbapenem hydrolysis by the OXA-48 β-lactamase [PDF]

, 2022
OXA-48 β-lactamases are frequently encountered in bacterial infections caused by carbapenem-resistant Gram-negative bacteria. Due to the importance of carbapenems in treatment of healthcare-associated infections, and the increasingly wide dissemination ...
Marc, van der Kamp, Tal, Moshe Weizmann, Adrian, Mulholland, James , Spencer, Viivi, Hirvonen   +4 more
core   +2 more sources

OXA-48-like carbapenemases: the phantom menace [PDF]

Journal of Antimicrobial Chemotherapy, 2012
OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly reported in enterobacterial species. To date, six OXA-48-like variants have been identified, with OXA-48 being the most widespread. They differ by a few amino acid substitutions or deletions (one to five amino acids).
Laurent, Poirel, Anaïs, Potron, Patrice, Nordmann   +2 more
openaire   +2 more sources

Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48

, 2021
Despite the advances in β-lactamase inhibitor development, limited options exist for the class D carbapenemase known as OXA-48. OXA-48 is one of the most prevalent carbapenemases in carbapenem-resistant Enterobacteriaceae infections and is not ...
Doris Mia Taylor, Justin Anglin (5953505), Doris Mia Taylor (8623326), Lingfei Wang, B. V. Venkataram Prasad, Lingfei Wang (2803441), Martin M. Matzuk, Justin Anglin, B. V. Venkataram Prasad (8623332), Banumathi Sankaran, Jin Wang, Liya Hu (2851901), Liya Hu, Timothy Palzkill (47788), Banumathi Sankaran (1341699), Timothy Palzkill, Martin M. Matzuk (200210), Jin Wang (29560)   +17 more
core   +1 more source

Epidemic spread of OXA-48 beta-lactamase in Croatia [PDF]

Journal of Medical Microbiology, 2018
A dramatic increase in OXA-48 β-lactamase was observed recently not only in large hospital centres, but also in smaller suburban hospital centres in geographic areas bordering Croatia. The aim of the study was to analyse the epidemiology, the mechanisms of antibiotic resistance and the routes of spread of OXA-48 carbapenemase in Croatia.Carbapenemase ...
Bedenić, Branka, Slade, Mia, Starčević, Lidija Žele, Sardelić, Sanda, Vranić-Ladavac, Mirna, Benčić, Ana, Zujić Atalić, Vlasta, Bogdan, Maja, Bubonja-Šonje, Marina, Tomić-Paradžik, Maja, Tot, Tatjana, Lukić-Grlić, Amarela, Drenjančević, Domagoj, Varda-Brkić, Dijana, Bandić-Pavlović, Daniela, Mihaljević, Slobodan, Zarfel, Gernot, Gužvinec, Marija, Conzemius, Rick, Barišić, Ivan, Tambić-Andraševic, Arjana   +20 more
openaire   +5 more sources

Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases [PDF]

, 2020
β-lactamase mediated antibiotic resistance threatens treatment of bacterial infections. OXA-48 enzymes are clinically important class D serine β-lactamases (SBLs) that confer resistance to most β-lactam antibiotics, including carbapenems. However, OXA-48
Adrian, Mulholland, Viivi H. A., Hirvonen, Marc W. van der, Kamp, James, Spencer   +3 more
core   +2 more sources

Spread of OXA-48-Encoding Plasmid in Turkey and Beyond [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT Eighteen carbapenem-resistant, OXA-48-positive enterobacterial isolates recovered from Turkey, Lebanon, Egypt, France, and Belgium were analyzed. In most isolates, similar 70-kb plasmids carrying the carbapenemase gene bla OXA-48 were identified.
Carrer, Amelie, Poirel, Laurent, Yilmaz, Mesut, Akan, Oezay Arikan, Feriha, Cilli, Cuzon, Gaelle, Matar, Ghassan, Honderlick, Patrick, Nordmann, Patrice   +8 more
openaire   +4 more sources