Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48 [PDF]
ACS Infectious Diseases, 2021 Despite the advances in β-lactamase inhibitor development, limited options exist for the class D carbapenemase known as OXA-48. OXA-48 is one of the most prevalent carbapenemases in carbapenem-resistant Enterobacteriaceae infections and is not susceptible to most available β-lactamase inhibitors. Here, we screened various low-molecular-weight compounds
Doris Mia Taylor +8 more
openaire +5 more sources
Evaluation of a New Phenotypic OXA-48 Disk Test for Differentiation of OXA-48 Carbapenemase-Producing Enterobacteriaceae Clinical Isolates [PDF]
Journal of Clinical Microbiology, 2015 ABSTRACT The current phenotypic methods for detecting carbapenemase-producing Enterobacteriaceae (CPE) allow differentiation between class A and B carbapenemases, but they cannot confirm in a single test class D OXA-48 carbapenemase producers.
Tsakris, A. +5 more
core +6 more sources
Discovery of bla(OXA-199), a chromosome-based bla(OXA-48)-like variant, in Shewanella xiamenensis. [PDF]
PLoS ONE, 2012 INTRODUCTION: bla(OXA-48) is a globally emerging carbapenemase-encoding gene. The progenitor of bla(OXA-48) appears to be a Shewanella species. The presence of the bla(OXA-48)-like gene was investigated for two Shewanella xiamenensis strains.
Zhiyong Zong
doaj +2 more sources
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs [PDF]
mSphere, 2019 Infections due to carbapenemase-producing Gram-negative pathogens are associated with limited treatment options and consequently lead to increased mortality and morbidity.
Christopher Fröhlich +5 more
doaj +4 more sources
Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]
Journal of Antimicrobial Chemotherapy, 2015 Abstract Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Oueslati S, Nordmann P, Poirel L
core +8 more sources
Arising Prevalence of OXA-48 producer Escherichia coli and OXA-48 with NDM co-producer Klebsiella pneumoniae Strains [PDF]
Romanian Journal of Laboratory Medicine, 2019 Background/aim: This prospective study aimed to determine the presence of the most common carbapenemase genes, blaOXA-48, blaKPC, blaIMP, blaVIM and blaNDM on carbapenem resistant clinical K.pneumoniae and E.coli isolates. Materials and methods: Isolates
Uskudar-Guclu Aylin +4 more
doaj +3 more sources
Clinical outcomes of carbapenem therapy in OXA-48–producing Enterobacterales infections: a French multicentre cohort, systematic review, and meta-analysis [PDF]
Emerging Microbes and InfectionsOXA-48–producing Enterobacterales (OXA-48-PE) represent a growing global health threat. Most of OXA-48–PE remain categorized susceptible to carbapenems, which might encourage their use despite uncertain clinical efficacy.
Laurent Dortet +8 more
doaj +2 more sources
Predominance of OXA-48 carbapenemase-producing Klebsiella pneumoniae strains in tertiary hospital in Sarajevo, Bosnia and Herzegovina [PDF]
Biomolecules & BiomedicineKlebsiella pneumoniae, a member of the Enterobacteriaceae family, demonstrates an increasing trend of resistance to carbapenems and is a common cause of both hospital- and community-acquired infections.
Amela Dedeić Ljubović +5 more
doaj +2 more sources
OXA-484, an OXA-48-Type Carbapenem-Hydrolyzing Class D β-Lactamase From Escherichia coli
Frontiers in Microbiology, 2021 OXA-48-like carbapenemases are among the most frequent carbapenemases in Gram-negative Enterobacterales worldwide with the highest prevalence in the Middle East, North Africa and Europe.
Julian Sommer +13 more
doaj +2 more sources
Cefiderocol Comparative Resistance and Clinical Predictors in CRE-BSI: Data from an OXA-48-Endemic Region with Rising OXA-48/NDM Coproducers. [PDF]
Antibiotics (Basel)Background/Objectives: Bloodstream infections (BSIs) caused by carbapenem-resistant Enterobacterales (CREs) are a growing public health threat due to limited therapeutic options and high mortality. In Turkey, oxacillinase-48 (OXA-48) producers predominate, while OXA-48/New Delhi metallo-β-lactamase (NDM) co-producers are increasingly detected. Although
Dumlu R, Mert A.
europepmc +4 more sources