Results 11 to 20 of about 49,551,276 (233)

To Be or Not to Be an OXA-48 Carbapenemase [PDF]

Microorganisms, 2022
Since the first description of OXA-48, more than forty variants have been recovered from Enterobacterales isolates. Whereas some OXA-48-related enzymes have been reported as conferring similar resistance patterns, namely, the hydrolysis of carbapenems ...
Laura Dabos, Saoussen Oueslati, Sandrine Bernabeu, Rémy A. Bonnin, Laurent Dortet, Thierry Naas   +5 more
doaj   +4 more sources

Detection of OXA-48-Carbapenemase-Producing Enterobacteriaceae using ChromID OXA-48 in Critical Care Patients in Egypt

Journal of Pure and Applied Microbiology, 2017
Carbapenems are a class of beta-lactam antibiotics with broad spectrum of activity. They are often considered as a last resort in treatment of infections caused by multidrug resistant organisms.
Basma A. El Awady, Mera G. Anan, Hamida A. Gohar, Mohamed H. Saleh   +3 more
doaj   +3 more sources

On the Evolvability of OXA-48. A comprehensive study of new functions within the β-lactamase OXA-48 [PDF]

, 2021
Our understanding of how antimicrobial resistance enzymes evolve to expand their substrate spectrum is limited. OXA-48, an enzyme able to catalyse the hydrolysis of β-lactam drugs, has become one of the most successfully disseminating β-lactamases. Although OXA-48 hydrolyses penicillins with high efficiency, its activity towards oxyimino cephalosporins,
Fröhlich, Christopher
core   +5 more sources

Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48 [PDF]

ACS Infectious Diseases, 2021
Despite the advances in β-lactamase inhibitor development, limited options exist for the class D carbapenemase known as OXA-48. OXA-48 is one of the most prevalent carbapenemases in carbapenem-resistant Enterobacteriaceae infections and is not susceptible to most available β-lactamase inhibitors. Here, we screened various low-molecular-weight compounds
Doris Mia Taylor, Justin Anglin, Liya Hu, Lingfei Wang, Banumathi Sankaran, Jin Wang, Martin M. Matzuk, B. V. Venkataram Prasad, Timothy Palzkill   +8 more
openaire   +5 more sources

Evaluation of a New Phenotypic OXA-48 Disk Test for Differentiation of OXA-48 Carbapenemase-Producing Enterobacteriaceae Clinical Isolates [PDF]

Journal of Clinical Microbiology, 2015
ABSTRACT The current phenotypic methods for detecting carbapenemase-producing Enterobacteriaceae (CPE) allow differentiation between class A and B carbapenemases, but they cannot confirm in a single test class D OXA-48 carbapenemase producers.
Tsakris, A., Poulou, A., Bogaerts, P., Dimitroulia, E., Pournaras, S., Glupczynski, Y.   +5 more
core   +6 more sources

Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]

Journal of Antimicrobial Chemotherapy, 2015
Abstract Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Oueslati S, Nordmann P, Poirel L
core   +8 more sources

OXA-484, an OXA-48-Type Carbapenem-Hydrolyzing Class D β-Lactamase From Escherichia coli

Frontiers in Microbiology, 2021
OXA-48-like carbapenemases are among the most frequent carbapenemases in Gram-negative Enterobacterales worldwide with the highest prevalence in the Middle East, North Africa and Europe.
Julian Sommer, Kristina M. Gerbracht, Felix F. Krause, Florian Wild, Manuela Tietgen, Manuela Tietgen, Manuela Tietgen, Sara Riedel-Christ, Janko Sattler, Axel Hamprecht, Axel Hamprecht, Volkhard A. J. Kempf, Volkhard A. J. Kempf, Stephan Göttig   +13 more
doaj   +2 more sources

Emergence of OXA-48 Carbapenemase in Taiwan

Journal of Microbiology, Immunology and Infection, 2015
[[abstract]]Purpose: OXA-48 producing Enterbacteriaceae are increased dramatically in Mediterranean countries in the past ten years. It has been found in Asia recently. Here, we report the emergence of OXA-48 during a nationwide survey in Taiwan. Methods:
Ma, Ling, Chen, Peijing, Lin, Fumei, Ding, Yijiun, Huang, Liyue, Chang, Jenchang, Liu, Qihong, Tai, Yukuo, Lu, Poliang   +8 more
openaire   +2 more sources

Investigation of OXA-48 Variants in Enterobacterales Isolates from an OXA-48-Endemic Region

Microbial Drug Resistance
Since their first identification in Türkiye in 2001, OXA-48-like carbapenemases have posed diagnostic challenges due to variant-specific phenotypic and resistance profiles. We investigated the distribution of OXA-48 variants and their association with antimicrobial susceptibility, carbapenem minimum inhibitory concentrations (MICs),
Şevval Arduç Tok, Leyla Genç, Ayşe Barış, Elif Aktaş   +3 more
openaire   +2 more sources

Molecular epidemiology of OXA-48-producing Klebsiella pneumoniae in France [PDF]

Clinical Microbiology and Infection, 2014
We characterized 53 OXA-48-producing Klebsiella pneumoniae (OXA-48-Kp) isolated between 2011 and 2013 in 21 French hospitals. All the isolates were genotyped using MLST and PFGE and the population structure of the species was determined by a nucleotide-based analysis of the entire K. pneumoniae MLST database.
Liapis, E., Pantel, A., Robert, J., Nicolas-Chanoine, M.-H., Cavalié, L., van Der Mee-Marquet, N., de Champs, C., Aissa, N., Eloy, C., Blanc, V., Guyeux, Christophe, Hocquet, D., Lavigne, J.-P., Bertrand, X., Renseigné, Non   +14 more
openaire   +5 more sources