Results 11 to 20 of about 30,220 (240)
Journal of Pure and Applied Microbiology, 2017 Carbapenems are a class of beta-lactam antibiotics with broad spectrum of activity. They are often considered as a last resort in treatment of infections caused by multidrug resistant organisms.
Basma A. El Awady +3 more
doaj +2 more sources
Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]
Journal of Antimicrobial Chemotherapy, 2015 Objectives: Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum ...
Nordmann, Patrice +2 more
core +6 more sources
Evaluation of an Immunochromatographic Lateral Flow Assay (OXA-48 K-SeT) for Rapid Detection of OXA-48-Like Carbapenemases in Enterobacteriaceae [PDF]
Journal of Clinical Microbiology, 2016 We evaluated an immunochromatographic lateral flow assay for the detection of OXA-48-like carbapenemases (OXA-48 K-SeT) in Enterobacteriaceae (n=82). 100% sensitivity and specificity was observed using bacteria recovered from both solid media and spiked ...
Betts, JW +4 more
core +5 more sources
Infection and Drug Resistance, 2022 Yicheng Wen,1,* Xiaofang Xie,1,* Ping Xu,2,* Chengcheng Yang,1 Zhichen Zhu,1 Jie Zhu,1 Jingnan Lv,1 Haifang Zhang,1 Liang Chen,3,4 Hong Du1 1Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou ...
Wen Y +9 more
doaj +3 more sources
To Be or Not to Be an OXA-48 Carbapenemase [PDF]
Microorganisms, 2022 Since the first description of OXA-48, more than forty variants have been recovered from Enterobacterales isolates. Whereas some OXA-48-related enzymes have been reported as conferring similar resistance patterns, namely, the hydrolysis of carbapenems ...
Laura Dabos +5 more
doaj +3 more sources
Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness [PDF]
Frontiers in Microbiology, 2019 OXA-48 is the most common carbapenemase in Enterobacterales in Germany and one of the most frequent carbapenemases worldwide. Several reports have associated blaOXA–48 with a virulent host phenotype.
Axel Hamprecht +14 more
doaj +5 more sources
Arising Prevalence of OXA-48 producer Escherichia coli and OXA-48 with NDM co-producer Klebsiella pneumoniae Strains [PDF]
Romanian Journal of Laboratory Medicine, 2019 Background/aim: This prospective study aimed to determine the presence of the most common carbapenemase genes, blaOXA-48, blaKPC, blaIMP, blaVIM and blaNDM on carbapenem resistant clinical K.pneumoniae and E.coli isolates. Materials and methods: Isolates
Uskudar-Guclu Aylin +4 more
doaj +2 more sources
Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48 [PDF]
ACS Infectious Diseases, 2021 Despite the advances in β-lactamase inhibitor development, limited options exist for the class D carbapenemase known as OXA-48. OXA-48 is one of the most prevalent carbapenemases in carbapenem-resistant Enterobacteriaceae infections and is not susceptible to most available β-lactamase inhibitors. Here, we screened various low-molecular-weight compounds
Doris Mia Taylor +8 more
openaire +3 more sources
OXA-48-like carbapenemases: the phantom menace [PDF]
Journal of Antimicrobial Chemotherapy, 2012 OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly reported in enterobacterial species. To date, six OXA-48-like variants have been identified, with OXA-48 being the most widespread. They differ by a few amino acid substitutions or deletions (one to five amino acids).
Laurent, Poirel +2 more
openaire +2 more sources
Comparative evaluation of a novel chromogenic medium (chromID OXA-48) for detection of OXA-48 producing Enterobacteriaceae [PDF]
Diagnostic Microbiology and Infectious Disease, 2013 Comparative evaluation of the recently developed chromogenic culture medium chromID OXA-48 (bioMérieux) with chromID CARBA (bioMérieux) and SUPERCARBA showed that chromID OXA-48 and SUPERCARBA media have the highest sensitivity for detection of OXA-48 producing Enterobacteriaceae (91% and 93%) comparatively to chromID CARBA (21 %).
Girlich, Delphine +3 more
openaire +2 more sources