Results 11 to 20 of about 24,184 (203)

OXA-484, an OXA-48-Type Carbapenem-Hydrolyzing Class D β-Lactamase From Escherichia coli

Frontiers in Microbiology, 2021
OXA-48-like carbapenemases are among the most frequent carbapenemases in Gram-negative Enterobacterales worldwide with the highest prevalence in the Middle East, North Africa and Europe.
Stephan Göttig, Volkhard Kempf, Janko Sattler   +2 more
exaly   +3 more sources

Clinical outcomes of carbapenem therapy in OXA-48–producing Enterobacterales infections: a French multicentre cohort, systematic review, and meta-analysis [PDF]

Emerging Microbes and Infections
OXA-48–producing Enterobacterales (OXA-48-PE) represent a growing global health threat. Most of OXA-48–PE remain categorized susceptible to carbapenems, which might encourage their use despite uncertain clinical efficacy.
Laurent Dortet, Charlotte Moreau, Aurélien Dinh, Rémy A. Bonnin, Lélia Escaut, Manon Seguret, Laura Weber, Samy Figueiredo, Benoît Pilmis   +8 more
doaj   +2 more sources

Predominance of OXA-48 carbapenemase-producing Klebsiella pneumoniae strains in tertiary hospital in Sarajevo, Bosnia and Herzegovina [PDF]

Biomolecules & Biomedicine
Klebsiella pneumoniae, a member of the Enterobacteriaceae family, demonstrates an increasing trend of resistance to carbapenems and is a common cause of both hospital- and community-acquired infections.
Amela Dedeić Ljubović, Đana Granov, Edina Zahirović, Azra Čamdžić, Adis Muhić, Irma Salimović Bešić   +5 more
doaj   +2 more sources

Cefiderocol Comparative Resistance and Clinical Predictors in CRE-BSI: Data from an OXA-48-Endemic Region with Rising OXA-48/NDM Coproducers. [PDF]

Antibiotics (Basel)
Background/Objectives: Bloodstream infections (BSIs) caused by carbapenem-resistant Enterobacterales (CREs) are a growing public health threat due to limited therapeutic options and high mortality. In Turkey, oxacillinase-48 (OXA-48) producers predominate, while OXA-48/New Delhi metallo-β-lactamase (NDM) co-producers are increasingly detected. Although
Dumlu R, Mert A.
europepmc   +4 more sources

OXA-48-like carbapenemases in Proteus mirabilis – novel genetic environments and a challenge for detection [PDF]

Emerging Microbes and Infections
OXA-48-like enzymes represent the most frequently detected carbapenemases in Enterobacterales in Western Europe, North Africa and the Middle East. In contrast to other species, the presence of OXA-48-like in Proteus mirabilis leads to an unusually ...
Janko Sattler, Janina Noster, Yvonne Stelzer, Martina Spille, Sina Schäfer, Kyriaki Xanthopoulou, Julian Sommer, Jonathan Jantsch, Silke Peter, Stephan Göttig, Sören G. Gatermann, Axel Hamprecht   +11 more
doaj   +2 more sources

Multicenter evaluation of ceftazidime-avibactam use in carbapenem-resistant Klebsiella pneumoniae bloodstream infections in OXA-48 endemic regions [PDF]

Scientific Reports
Data in the literature on the use of ceftazidime-avibactam (CAZ-AVI) in carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are limited especially in OXA-48 (Oxacillinase-48) predominant regions.
Ali Mert, Okan Derin, Halis Akalın, Rıdvan Dumlu, Sibel Gündeş, Rehile Zengin, Sesin Kocagöz, Yasemin Gündoğdu, İftihar Köksal, Demet Yalçın, Cemal Üstün, Mahir Kapmaz, Levent Görenek, Kadriye Karahangil, Füsun Can, Consortium, Önder Ergönül   +16 more
doaj   +2 more sources

Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48 [PDF]

ACS Infectious Diseases, 2021
Despite the advances in β-lactamase inhibitor development, limited options exist for the class D carbapenemase known as OXA-48. OXA-48 is one of the most prevalent carbapenemases in carbapenem-resistant Enterobacteriaceae infections and is not susceptible to most available β-lactamase inhibitors. Here, we screened various low-molecular-weight compounds
Doris Mia Taylor, Justin Anglin, Liya Hu, Lingfei Wang, Banumathi Sankaran, Jin Wang, Martin M. Matzuk, B. V. Venkataram Prasad, Timothy Palzkill   +8 more
openaire   +3 more sources

Spread of the blaOXA-48/IncL Plasmid within and between Dogs in City Parks, France

Microbiology Spectrum, 2022
The blaOXA-48/IncL plasmid is increasingly reported in dogs, even in the absence of carbapenem use in animals. In this study, we witnessed the spread of this plasmid within and between dogs sharing the same relaxing area.
Marisa Haenni, Véronique Métayer, Agnese Lupo, Antoine Drapeau, Jean-Yves Madec   +4 more
doaj   +1 more source

Treatment of Infections by OXA-48-Producing Enterobacteriaceae [PDF]

Antimicrobial Agents and Chemotherapy, 2018
Carbapenemase-producing Enterobacteriaceae (CPE) contribute significantly to the global public health threat of antimicrobial resistance. OXA-48 and its variants are unique carbapenemases with low-level hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins.
Adam Stewart, Patrick Harris, Andrew Henderson, David Paterson   +3 more
openaire   +5 more sources

Discovery of bla(OXA-199), a chromosome-based bla(OXA-48)-like variant, in Shewanella xiamenensis. [PDF]

PLoS ONE, 2012
INTRODUCTION: bla(OXA-48) is a globally emerging carbapenemase-encoding gene. The progenitor of bla(OXA-48) appears to be a Shewanella species. The presence of the bla(OXA-48)-like gene was investigated for two Shewanella xiamenensis strains.
Zhiyong Zong
doaj   +1 more source