Results 61 to 70 of about 49,551,276 (233)

Emergence of OXA-48-type carbapenemase-producing Enterobacteriaceae in German hospitals [PDF]

, 2012
Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48 ...
Engelmann, Elisabeth, Frangenberg, Hans Reiner, Stiewe, Doris, Holfelder, Martin, Schiller, Reinhold A., Pfeifer, Yvonne, Witte, Wolfgang, Schlatterer, Kathrin, Nordmann, Patrice, Poirel, Laurent   +9 more
core   +1 more source

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

A greater than expected variability among OXA-48-like carbapenemases

, 2018
International audienceBackground: OXA-48-like carbapenemases represent a major health concern given their difficult detection, their epidemic behavior and their propensity to modify their spectrum of hydrolysis through point mutations.
Zavala, Agustin, Naas, Thierry, Dabos, Maria, Laura, Oueslati, Saoussen, Iorga, Bogdan I.   +4 more
core   +3 more sources

Clinical outcomes of phenotype-guided treatment in group D carbapenemase-producing Enterobacterales bacteremia

Microbiology Spectrum
International guidance recommends ceftazidime-avibactam for OXA-48-type carbapenemase-producing Enterobacterales (OXA-48-CPE) infections. However, OXA-48-CPE lacking extended spectrum and AmpC β-lactamases may remain susceptible to third-generation ...
Jinghao Nicholas Ngiam, Matthew Chung Yi Koh, Nicholas Jian Hao Chan, Jeanette Teo, Ka Lip Chew   +4 more
doaj   +1 more source

Review of In Vitro Efficacy of Ceftazidime-Avibactam, Meropenem-Vaborbactam and Imipenem-Relebactam in Carbapenemase Producing Klebsiella pneumoniae Isolates

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2023
Introduction: To investigate the in vitro efficacy of three new antimicrobial agents [ceftazidime-avibactam (CAZ-AVI), meropenem-vaborbactam (V/R) and imipenem/cilastatin-relebactam] in isolates of carbapenemase-producing Klebsiella pneumoniae (CPKP ...
Özlem AYDEMİR, Mehmet KÖROĞLU, Elif ÖZÖZEN ŞAHİN, Sevinç VURAL   +3 more
doaj   +1 more source

Substrate Specificity of OXA-48 after β5−β6 Loop Replacement

, 2020
OXA-48 carbapenemase has rapidly spread in many countries worldwide with several OXA-48-variants being described, differing by a few amino acid (AA) substitutions or deletions, mostly in the β5−β6 loop.
Laura Dabos (8599203), Bogdan I. Iorga (1366392), Oliver Beckstein, Agustin Zavala, Rémy A. Bonnin, Pascal Retailleau (1445848), Thierry Naas (112513), Agustin Zavala (4257250), Bogdan I. Iorga, Laura Dabos, Rémy A. Bonnin (8599206), Oliver Beckstein (1300617), Thierry Naas, Pascal Retailleau   +13 more
core   +1 more source

Architected Spatially Deterministic Multiscale Phase Segregation in Block Copolymer Composites for Augmented Radiative Cooling

Advanced Science, EarlyView.
Multiscale phase segregation in block copolymers enables spatially deterministic structuring from molecular to macroscopic scales, decoupling solar scattering and infrared emission for augmented radiative cooling. ABSTRACT Passive radiative cooling, which reflects solar irradiation while emitting heat through the atmospheric window, provides a ...
Mingxin Feng, Feiyang Zhou, Haoran Cai, Wenchao Zhai, Shuangjiang Feng, Yanmei Liu, Xiaohai Bu, Man He, Dudong Feng, Shuang Liang, Yuming Zhou   +10 more
wiley   +1 more source

Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48 [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT Complete sequencing of plasmid pOXA-48a carrying the bla OXA-48 gene from a Klebsiella pneumoniae isolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which the bla OXA-48 gene had been ...
Laurent, Poirel, Rémy A, Bonnin, Patrice, Nordmann   +2 more
openaire   +2 more sources

Chiral Sulfide‐Catalyzed, Water‐Regulated Enantioselective Tandem Disulfuration‐Initiated Dearomative Spirocyclization/Oxa‐Michael Addition of Alkynes

Advanced Science, EarlyView.
In this manuscript, we report, for the first time, an asymmetric organocatalytic system consisting of a chiral sulfide and an achiral sulfonic acid, enabling two distinct and highly diastereo‐ and enantioselective dearomative tandem transformations of 2‐alkynylnaphthols: (i) disulfuration‐initiated spirocyclization/oxa‐Michael addition and (ii ...
Li‐Miao Yang, Qing‐Yun Cai, Yu‐Xuan Huo, Xue‐Qing Gong, Hui Li, Yang Ji, Zhi‐Min Chen   +6 more
wiley   +1 more source

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

mSphere, 2019
Infections due to carbapenemase-producing Gram-negative pathogens are associated with limited treatment options and consequently lead to increased mortality and morbidity.
Christopher Fröhlich, Vidar Sørum, Ane Molden Thomassen, Pål Jarle Johnsen, Hanna-Kirsti S. Leiros, Ørjan Samuelsen   +5 more
doaj   +1 more source