Results 61 to 70 of about 1,076,076 (217)

Predominance of OXA-48 Carbapenemase-Producing Enterobacterales in a Moroccan Hospital

International Journal of Microbiology, 2023
Objective. The emergence of carbapenemase-producing Enterobacterales (CPE) is a major concern that is increasingly reported worldwide. Our study aimed at investigating the resistance of CPE isolates in a Moroccan teaching hospital using phenotypic and genotypic methods. Methods.
Elmehdi Belouad, Adil Maleb, Nadia El Mrimar, Fatna Bssaibis, Adil Maleb, Mostafa Elouennass   +5 more
openaire   +3 more sources

Evaluation of In Vitro Activity of Double-Carbapenem Combinations against KPC-2-, OXA-48- and NDM-Producing Escherichia coli and Klebsiella pneumoniae

Antibiotics, 2022
Double-carbapenem combinations have shown synergistic potential against carbapenemase-producing Enterobacterales, but data remain inconclusive. This study evaluated the activity of double-carbapenem combinations against 51 clinical KPC-2-, OXA-48-, NDM-1,
Lisa Allander, Karin Vickberg, Pernilla Lagerbäck, Linus Sandegren, Thomas Tängdén   +4 more
doaj   +1 more source

Detection of Carbapenemase-producing Enterobacteriaceae using Chromogenic Medium, ChromidID OXA-48, in Critical Care Patients of Kasr Al-Ainy Hospital in Egypt

, 2017
Carbapenems are a class of beta-lactam antibiotics with broad spectrum of activity. They are often considered as a last resort in treatment of infections caused by multidrug resistant organisms.
Basma A. El Awady, Mera G. Anan, Mera Anan, Hamida A. Gohar, Hamida Gohar, Mohamed Saleh, Mohamed H. Saleh   +6 more
core   +1 more source

Performance of a new in-house medium Carba MTL-broth for the rapid detection of carbapenemase-producing Enterobacteriaceae

Journal of Infection in Developing Countries, 2019
Introduction: The spread of carbapenemase-producing Enterobacteriaceae (CPE) represents a major public health issue. Methods allowing rapid detection of carbapenemases in developing countries are therefore urgently needed.
Assia Mairi, Abdelaziz Touati, Alix Pantel, Catherine Dunyach-Remy, Albert Sotto, Christophe De Champs, Jean-Philippe Lavigne   +6 more
doaj   +1 more source

Review of In Vitro Efficacy of Ceftazidime-Avibactam, Meropenem-Vaborbactam and Imipenem-Relebactam in Carbapenemase Producing Klebsiella pneumoniae Isolates

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2023
Introduction: To investigate the in vitro efficacy of three new antimicrobial agents [ceftazidime-avibactam (CAZ-AVI), meropenem-vaborbactam (V/R) and imipenem/cilastatin-relebactam] in isolates of carbapenemase-producing Klebsiella pneumoniae (CPKP ...
Özlem AYDEMİR, Mehmet KÖROĞLU, Elif ÖZÖZEN ŞAHİN, Sevinç VURAL   +3 more
doaj   +1 more source

Multicenter evaluation of ceftazidime-avibactam use in carbapenem-resistant Klebsiella pneumoniae bloodstream infections in OXA-48 endemic regions. [PDF]

Sci Rep
Data in the literature on the use of ceftazidime-avibactam (CAZ-AVI) in carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are limited especially in OXA-48 (Oxacillinase-48) predominant regions.
Mert A, Derin O, Akalın H, Dumlu R, Gündeş S, Zengin R, Kocagöz S, Gündoğdu Y, Köksal İ, Yalçın D, Üstün C, Kapmaz M, Görenek L, Karahangil K, Can F, Consortium, Ergönül Ö.   +16 more
europepmc   +2 more sources

Clinical outcomes of phenotype-guided treatment in group D carbapenemase-producing Enterobacterales bacteremia

Microbiology Spectrum
International guidance recommends ceftazidime-avibactam for OXA-48-type carbapenemase-producing Enterobacterales (OXA-48-CPE) infections. However, OXA-48-CPE lacking extended spectrum and AmpC β-lactamases may remain susceptible to third-generation ...
Jinghao Nicholas Ngiam, Matthew Chung Yi Koh, Nicholas Jian Hao Chan, Jeanette Teo, Ka Lip Chew   +4 more
doaj   +1 more source

Drug Resistance and Molecular Characteristics of Carbapenem-Resistant OXA-48-Producing Klebsiella pneumoniae Strains in Hainan, China

Microorganisms, 2023
Background: The emergence and global spread of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are of great concern to health services worldwide.
Min Ye, Lei Liu, Bin Liu, Xiangdong Zhou, Qi Li   +4 more
doaj   +1 more source

Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48 [PDF]

Antimicrobial Agents and Chemotherapy, 2012
ABSTRACT Complete sequencing of plasmid pOXA-48a carrying the bla OXA-48 gene from a Klebsiella pneumoniae isolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which the bla OXA-48 gene had been ...
Laurent, Poirel, Rémy A, Bonnin, Patrice, Nordmann   +2 more
openaire   +2 more sources

Substrate Specificity of OXA-48 after β5−β6 Loop Replacement

, 2020
OXA-48 carbapenemase has rapidly spread in many countries worldwide with several OXA-48-variants being described, differing by a few amino acid (AA) substitutions or deletions, mostly in the β5−β6 loop.
Laura Dabos (8599203), Bogdan I. Iorga (1366392), Oliver Beckstein, Agustin Zavala, Rémy A. Bonnin, Pascal Retailleau (1445848), Thierry Naas (112513), Agustin Zavala (4257250), Bogdan I. Iorga, Laura Dabos, Rémy A. Bonnin (8599206), Oliver Beckstein (1300617), Thierry Naas, Pascal Retailleau   +13 more
core   +1 more source