Results 61 to 70 of about 30,220 (240)

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Review of In Vitro Efficacy of Ceftazidime-Avibactam, Meropenem-Vaborbactam and Imipenem-Relebactam in Carbapenemase Producing Klebsiella pneumoniae Isolates

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2023
Introduction: To investigate the in vitro efficacy of three new antimicrobial agents [ceftazidime-avibactam (CAZ-AVI), meropenem-vaborbactam (V/R) and imipenem/cilastatin-relebactam] in isolates of carbapenemase-producing Klebsiella pneumoniae (CPKP ...
Özlem AYDEMİR, Mehmet KÖROĞLU, Elif ÖZÖZEN ŞAHİN, Sevinç VURAL   +3 more
doaj   +1 more source

Whole genome sequencing,molecular typing and in vivovirulence of OXA-48-producingEscherichia coli isolates includingST131 H30-Rx, H22 and H41subclones [PDF]

, 2017
Carbapenem-resistant Enterobacteriaceae, including the increasingly reported OXA-48 Escherichia coli producers, are an emerging public health threat worldwide.
A Carattoli, A Carattoli, A Carrër, A Mora, A Potron, AHAM Hoek van, DR Zerbino, E Zankari, F Tanfous Ben, G Dahbi, G Gerhold, G Peirano, GC Cerqueira, J Blanco, J Fernández, J Fernández, JF Turton, JR Johnson, JR Johnson, K Power, KG Joensen, KG Joensen, L Chen, L Poirel, L Poirel, LW Riley, M Golebiewski, M-H Nicolas-Chanoine, MP Garcillán-Barcia, MV Larsen, N Stoesser, N-F Alikhan, NK Petty, O Clermont, O Clermont, P Nordmann, PL Ho, R Beyrouthy, R Beyrouthy, RR Spurbeck, S Ktari, SJ Weissman, SK Gupta, T Giani, T Wirth, TJ Johnson, VF Lanza, X Liu   +47 more
core   +7 more sources

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Performance of a new in-house medium Carba MTL-broth for the rapid detection of carbapenemase-producing Enterobacteriaceae

Journal of Infection in Developing Countries, 2019
Introduction: The spread of carbapenemase-producing Enterobacteriaceae (CPE) represents a major public health issue. Methods allowing rapid detection of carbapenemases in developing countries are therefore urgently needed.
Assia Mairi, Abdelaziz Touati, Alix Pantel, Catherine Dunyach-Remy, Albert Sotto, Christophe De Champs, Jean-Philippe Lavigne   +6 more
doaj   +1 more source

Drug Resistance and Molecular Characteristics of Carbapenem-Resistant OXA-48-Producing Klebsiella pneumoniae Strains in Hainan, China

Microorganisms, 2023
Background: The emergence and global spread of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are of great concern to health services worldwide.
Min Ye, Lei Liu, Bin Liu, Xiangdong Zhou, Qi Li   +4 more
doaj   +1 more source

Molecular epidemiology of OXA-48-producing Klebsiella pneumoniae in France [PDF]

Clinical Microbiology and Infection, 2014
We characterized 53 OXA-48-producing Klebsiella pneumoniae (OXA-48-Kp) isolated between 2011 and 2013 in 21 French hospitals. All the isolates were genotyped using MLST and PFGE and the population structure of the species was determined by a nucleotide-based analysis of the entire K. pneumoniae MLST database.
Liapis, E., Pantel, A., Robert, J., Nicolas-Chanoine, M.-H., Cavalié, L., van Der Mee-Marquet, N., de Champs, C., Aissa, N., Eloy, C., Blanc, V., Guyeux, Christophe, Hocquet, D., Lavigne, J.-P., Bertrand, X., Renseigné, Non   +14 more
openaire   +3 more sources

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, EarlyView.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Prevalence of class D carbapenemases among extended-spectrum β-lactamases producing Escherichia coli isolates from educational hospitals in Shahrekord [PDF]

, 2016
Introduction: Extended-spectrum β-lactamases (ESBLs) are a set of plasmid-borne, various and quickly evolving enzymes that are a main therapeutic issue now-a-days for inpatient and outpatient treatment.
Damavandi, M.-S., Gholipour, A., Lotifpour, M.   +2 more
core   +1 more source

Genome Sequence of OXA-48 Carbapenemase-Producing Klebsiella pneumoniae KpO3210 [PDF]

Journal of Bacteriology, 2012
ABSTRACT Klebsiella pneumoniae KpO3210 is a OXA-48 carbapenemase-producing isolate obtained from a blood culture in the context of an outbreak in Hospital Universitario La Paz (Madrid, Spain) in 2010. It belongs to the major clone detected during the outbreak and is resistant to all beta-lactams and to several other ...
Jan-Jaap, Wesselink, Elena, López-Camacho, Santiago, de la Peña, Ricardo, Ramos-Ruiz, Guillermo, Ruiz-Carrascoso, Silvia, Lusa-Bernal, Victor M, Fernández-Soria, Rosa, Gómez-Gil, Paulino, Gomez-Puertas, Jesús, Mingorance   +9 more
openaire   +2 more sources