Results 61 to 70 of about 24,184 (203)
Microbiology SpectrumSince 2022, the diversity of OXA-48 variants has increased in France. We analyzed the dissemination of five recent variants (OXA-1181, OXA-1201, OXA-1205, OXA-1207, and OXA-1226) mostly identified on plasmids in high-risk Escherichia coli clones.
Léa Bientz +5 more
doaj +1 more source
OXA-48-like carbapenemases producing Enterobacteriaceae in different niches [PDF]
European Journal of Clinical Microbiology & Infectious Diseases, 2017 The emergence of carbapenem-resistant enterobacterial species poses a serious threat to public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are widely distributed among Enterobacteriaceae, with significant geographical differences.
Mairi, Assia +4 more
openaire +3 more sources
Advanced Science, EarlyView.This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu +9 more
wiley +1 more source
Journal of Microbiology, Immunology and Infection, 2021 Background: We describe the molecular epidemiology and resistance patterns of blaOXA-48 Klebsiella pneumoniae and Escherichia coli in Taiwan. Methods: In this multicenter surveillance study from January 2012 to August 2015, the identified blaOXA-48 ...
Ching-Hsun Wang +6 more
doaj +1 more source
Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48 [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACT Complete sequencing of plasmid pOXA-48a carrying the bla OXA-48 gene from a Klebsiella pneumoniae isolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which the bla OXA-48 gene had been ...
Laurent, Poirel +2 more
openaire +2 more sources
Advanced Science, EarlyView.Liquid atmospheric pressure matrix‐assisted laser desorption/ionization (LAP‐MALDI) mass spectrometry (MS) provides multiplexed biotyping of microbial cultures using a fast and simple workflow. This is demonstrated for clinically relevant bacteria, resulting in accurate antimicrobial resistance (AMR) detection, speciation by MS/MS sequencing and ...
Lily R. Adair +3 more
wiley +1 more source
Microorganisms, 2023 Background: The emergence and global spread of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are of great concern to health services worldwide.
Min Ye +4 more
doaj +1 more source
Advanced Science, EarlyView.GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun +16 more
wiley +1 more source
Detection of OXA-48 Carbapenemase in the Pandemic Clone Escherichia coli O25b:H4-ST131 in the Course of Investigation of an Outbreak of OXA-48-Producing Klebsiella pneumoniae [PDF]
Antimicrobial Agents and Chemotherapy, 2012 Reports of carbapenemase producing Enterobacteriaceae (CPE) have increased dramatically in the past decade.…
Morris, D. +8 more
openaire +1 more source
Journal of Pure and Applied Microbiology, 2020 Members of Enterobacteriaceae family are responsible for both community and hospital acquired infections. Because of development of antimicrobial resistance carbapenem has remained as last resort of drug for treatment of infections caused by these ...
Satyajeet K. Pawar +4 more
doaj +1 more source