Results 71 to 80 of about 49,551,276 (233)

Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]

, 2017
Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Oueslati, Saoussen, Nordmann, Patrice, Poirel, Laurent   +2 more
core  

Structural and biochemical features of OXA-517: a Carbapenem and expanded-spectrum Cephalosporin hydrolyzing OXA-48 variant

, 2023
International audienceOXA-48-producing Enterobacterales have now widely disseminated throughout the world. Several variants have now been reported, differing by just a few amino-acid substitutions or deletions, mostly in the region of the loop β5-β6.
Dabos, Laura, Raczynska, Joanna, Zavala, Agustin, Bogaerts, Pierre, Glupczynski, Youri, Peyrat, Aurélie, Glupczynski, Gerald, Girlich, Delphine, Iorga, Bogdan, Iorga, Bogdan I, Jaskólski, Mariusz, Bonnin, Remy A, Bonnin, Remy, Dortet, Laurent, Naas, Thierry, Retailleau, Pascal, Raczynska, Joanna E, Raczynska, Joanna E., Joanna E. Raczynska, Agustin Zavala, Iorga, Bogdan I., Laura Dabos, Remy A. Bonnin, Pierre Bogaerts, Pascal Retailleau, Youri Glupczynski, Mariusz Jaskólski, Delphine Girlich, Aurélie Peyrat, Bogdan I. Iorga, Laurent Dortet, Bonnin, Remy A., Thierry Naas   +32 more
core   +1 more source

Production of OXA-48 carbapenemase acts as an independent risk factor for poor outcome in Klebsiella pneumoniae infection. [PDF]

, 2023
20.500.12530/87852To know whether the production of OXA-48 carbapenemase exerts an independent impact on the outcome of Klebsiella pneumoniae infection, once adjusted by clinical syndrome and baseline risk factors.
Corbella, Laura, Fernández-Ruiz, Mario, Ruiz-Ruigómez, María, Lizasoain, Manuel, Rodríguez-Goncer, Isabel, López-Medrano, Francisco, San-Juan, Rafael, Silva, José Tiago, Hernández-Jiménez, Pilar, Villa, Jennifer, Aguado, José María   +10 more
core   +1 more source

Emergence and characterization of new OXA-181 variants in France: OXA-1181, OXA-1201, OXA-1205, OXA-1207, and OXA-1226

Microbiology Spectrum
Since 2022, the diversity of OXA-48 variants has increased in France. We analyzed the dissemination of five recent variants (OXA-1181, OXA-1201, OXA-1205, OXA-1207, and OXA-1226) mostly identified on plasmids in high-risk Escherichia coli clones.
Léa Bientz, Réva Nermont, Cécile Emeraud, Thierry Naas, Rémy A. Bonnin, Laurent Dortet   +5 more
doaj   +1 more source

Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases. [PDF]

RSC Med Chem
Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, challenge the treatment of multi-drug resistant bacteria. The OXA-48 carbapenemase is widely disseminated in Enterobacterales, necessitating new treatments for producer strains ...
Hoff JF, Goudar KE, Calvopiña K, Beer M, Hinchliffe P, Shaw JM, Tooke CL, Takebayashi Y, Cadzow AF, Harmer NJ, Mulholland AJ, Schofield CJ, Spencer J.   +12 more
europepmc   +2 more sources

Emergence and Spread of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae [PDF]

, 2015
Since 2001, ten more OXA-48 variants have been identified. Shewanella spp. has been thought to be the original host for OXA-48-like enzymes. These enzymes strongly hydrolyze penicillins and weakly hydrolyze carbapenems, with very weak activity against ...
이경원, 정석훈
core   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Rising Threat of OXA-48 and other Carbapenemase Encoding Genes among Carbapenem Resistant Enterobacteriaceae in India

Journal of Pure and Applied Microbiology, 2020
Members of Enterobacteriaceae family are responsible for both community and hospital acquired infections. Because of development of antimicrobial resistance carbapenem has remained as last resort of drug for treatment of infections caused by these ...
Satyajeet K. Pawar, Shivaji T. Mohite, Kailash D. Datkhile, Madhavi N. Patil, Satish V. Kakade   +4 more
doaj   +1 more source

EVALUATION OF FOUR PHENOTYPIC TESTS FOR THE DETECTION OF OXA-48-TYPE CARBAPENEMASE IN ENTEROBACTERIACEAE [PDF]

Romanian Journal of Infectious Diseases, 2016
Carbapenemase-producing Enterobacteriaceae have the potential to rapid dissemination in healthcare settings, becoming a major infection control and public health concern.
Daniela Talapan, Olga Mihaela Dorobat, Coralia Bleotu, Ioana Aldea, Laura Necula, Dragos Florea, Gabriel Adrian Popescu, Adrian Streinu-Cercel, Alexandru Rafila   +8 more
doaj   +1 more source

Fire‐Safe Polymeric Insulation Foams for Energy‐Efficient and Low‐Carbon Buildings

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review systematically summarizes recent advances in fire‐safe polymeric insulation foams, emphasizing the balance among flame retardancy, thermal insulation, mechanical reliability, and long‐term durability. By linking material‐level thermophysical properties with building cooling‐energy demand and operational carbon emissions, it establishes a ...
Qinhe Guo, Jiayi Pan, Dehui Jia, Min Chen, Danni Pan, Yao Yuan, Ying Pan, Yan Zhang, Lulu Xu, Kate Nguyen, Wei Wang   +10 more
wiley   +1 more source