Results 81 to 90 of about 24,184 (203)

A Unified Approach for the Synthesis of Conformationally Locked and sp2‐sp3 Fused Hybrids

Chemistry – A European Journal, EarlyView.
This study presents a systematic platform to build rigid sp2–sp3 hybrids via benzyne cycloadditions. Arene‑fused bicyclic oxa‐, aza‐, and carbocycles are converted into medicinally relevant amino acids and applied to Enalapril analogues synthesis. The hybrids combine aromatic interactions with 3D rigidity, tuning lipophilicity, pKa, and solubility ...
Ervis Saraci, Federica Plavi, Giovanni Viscardi, Chad N. Ungarean, Massimo Boiocchi, Christophe Salome, Quentin Lefebvre, Thomas C. Fessard, David Sarlah   +8 more
wiley   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, EarlyView.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Stereoselective and Diastereospecific Aminosilylation and Hydrosilylation of Heterobicyclic Alkenes by Copper Catalysis Under Mild Conditions

European Journal of Organic Chemistry, EarlyView.
An efficient and straightforward methodology for the stereoselective and diastereospecific aminosilylation and hydrosilylation of heterobicyclic norbornene derivatives is introduced. The mild conditions enable the functionalization of norbornene substrates with broad functional‐group tolerance.
Daniel Kamzol, Wende Chen, Aleksander Hoffman, René Wilhelm   +3 more
wiley   +1 more source

Primeros aislados de Escherichia coli con carbapenemasas tipo OXA 48 en Panamá

Infectio
La OXA-48, una beta-lactamasa de clase D, posee una capacidad de diseminación muy alta, hidroliza los carbapenemicos débilmente; sin embargo, cuando se asocia con otros mecanismos de resistencia como las B-lactamasas de espectro extendido (ESBL), AmpC o ...
Olmedo Villarreal
doaj   +1 more source

Countrywide spread of OXA-48 carbapenemase in Lebanon: surveillance and genetic characterization of carbapenem-non-susceptible Enterobacteriaceae in 10 hospitals over a one-year period

International Journal of Infectious Diseases, 2014
Objectives: To detect, characterize, and assess the genetic clonality of carbapenem-non-susceptible Enterobacteriaceae in 10 Lebanese hospitals in 2012. Methods: Selected Enterobacteriaceae isolates with reduced susceptibility to carbapenems were subject
D. Hammoudi, C. Ayoub Moubareck, J. Aires, A. Adaime, A. Barakat, N. Fayad, N. Hakime, M. Houmani, T. Itani, Z. Najjar, M. Suleiman, R. Sarraf, D. Karam Sarkis   +12 more
doaj   +1 more source

Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases

iMetaOmics, EarlyView.
An integrative metagenomic framework combining sequence, structural, and functional inference reveals a phylogenetically diverse and structurally conserved repertoire of putative beta‐lactamases across Antarctic soil microbiomes, with predominance of class A and subclass B3 enzymes and limited but detectable associations with mobile genetic elements ...
José Coche‐Miranda, Patricio Arros, Nicolás Canales, Camilo Berríos‐Pastén, Gastón Azziz, Rosalba Lagos, Julieta Orlando, Francisco P. Chávez, Andrés E. Marcoleta   +8 more
wiley   +1 more source

First report of carbapenemase OXA-181-producing Serratia marcescens

Journal of Global Antimicrobial Resistance, 2021
Aziza Messaoudi, Wejdene Mansour, Lamia Tilouche, Pierre Châtre, Antoine Drapeau, Chrifa Chaouch, Sana Azaiez, Olfa Bouallègue, Jean-Yves Madec, Marisa Haenni   +9 more
doaj   +1 more source

Frequency and Benefits of Oxa- 48-Like Gene Detection in Imipenem Resistant Enterobacterales Using Phenotypic Methods

Pakistan Armed Forces Medical Journal
Objectives: To determine frequency of OXA-48 like gene in CRE and to find effectiveness of phenotypic methods for OXA-48 like gene detection. Study Design: cross-sectional study.
Saeeda Bano, Shahina Yasmin, Tariq Butt, Shazia Taj, Nehaj Tariq, Aleena Butt   +5 more
doaj   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Frequency of OXA-48 Gene in the Enterobacteriaceae in a Tertiary Care Hospital in Lahore [PDF]

Journal of Sharif Medical & Dental College, 2019
Objective: The objective of this study was to determine the frequency of OXA-48 gene in the Enterobacteriaceae isolated from the clinical samples of hospitalized patients.
Asma Yaqoob, Namra Yunus, Sameen Bit Ali, Hirra Ghaffar, Aqsa Aslam, Sadaf Nasir   +5 more
doaj