Results 81 to 90 of about 1,473,629 (228)
Phenotypic and genotypic characteristics of OXA-48-producing K. pneumoniae isolates.
, 2016 Phenotypic and genotypic characteristics of OXA-48-producing K. pneumoniae isolates.
Yanning Ma (3143427) +6 more
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Detection of OXA-48 Carbapenemase in the Pandemic Clone Escherichia coli O25b:H4-ST131 in the Course of Investigation of an Outbreak of OXA-48-Producing Klebsiella pneumoniae [PDF]
Antimicrobial Agents and Chemotherapy, 2012 Reports of carbapenemase producing Enterobacteriaceae (CPE) have increased dramatically in the past decade.…
Morris, D. +8 more
openaire +1 more source
Heterogeneous hydrolytic features for OXA-48-like β-lactamases [PDF]
, 2017 Objectives Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins.
Oueslati, Saoussen +2 more
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Angewandte Chemie, EarlyView.Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann +10 more
wiley +1 more source
On the Evolvability of OXA-48. A comprehensive study of new functions within the β-lactamase OXA-48
, 2021 Our understanding of how antimicrobial resistance enzymes evolve to expand their substrate spectrum is limited. OXA-48, an enzyme able to catalyse the hydrolysis of β-lactam drugs, has become one of the most successfully disseminating β-lactamases. Although OXA-48 hydrolyses penicillins with high efficiency, its activity towards oxyimino cephalosporins,
openaire +1 more source
Carbapenem Resistance of OXA-48 Gene Coding in Klebsiella Pneumoniae and Escherichia Coli
Annals of Mechnikov's Institute, 2021 Introduction: Bacteria that treated with antibiotics has ability to adapt or mutate due to form a defend mechanism. OXA-48 produces isolate that have ability as a resistance to drugs and all β-lactam, including cephalosporin, cephamycin, monobactone, and
Nita Parisa +2 more
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Substrate Specificity of OXA-48 after β5−β6 Loop Replacement
, 2020 OXA-48 carbapenemase has rapidly spread in many countries worldwide with several OXA-48-variants being described, differing by a few amino acid (AA) substitutions or deletions, mostly in the β5−β6 loop.
Laura Dabos (8599203) +13 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
BMEMat, EarlyView.Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang +8 more
wiley +1 more source
Detection of OXA-181/OXA-48 carbapenemase producing Enterobacteriaceae in Bangladesh
IMC Journal of Medical Science, 2015 Carbapenem resistant Enterobacteriaceae (CRE) is becoming a major public health concern globally. Detection of carbapenem hydrolyzing enzyme carbapenemase in Enterobacteriaceae is important to institute appropriate therapy and to initiate preventive ...
Rehana Khatun, S.M. Shamsuzzaman
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