Results 101 to 110 of about 1,473,629 (228)

Primeros aislados de Escherichia coli con carbapenemasas tipo OXA 48 en Panamá

Infectio
La OXA-48, una beta-lactamasa de clase D, posee una capacidad de diseminación muy alta, hidroliza los carbapenemicos débilmente; sin embargo, cuando se asocia con otros mecanismos de resistencia como las B-lactamasas de espectro extendido (ESBL), AmpC o ...
Olmedo Villarreal
doaj   +1 more source

Countrywide spread of OXA-48 carbapenemase in Lebanon: surveillance and genetic characterization of carbapenem-non-susceptible Enterobacteriaceae in 10 hospitals over a one-year period

International Journal of Infectious Diseases, 2014
Objectives: To detect, characterize, and assess the genetic clonality of carbapenem-non-susceptible Enterobacteriaceae in 10 Lebanese hospitals in 2012. Methods: Selected Enterobacteriaceae isolates with reduced susceptibility to carbapenems were subject
D. Hammoudi, C. Ayoub Moubareck, J. Aires, A. Adaime, A. Barakat, N. Fayad, N. Hakime, M. Houmani, T. Itani, Z. Najjar, M. Suleiman, R. Sarraf, D. Karam Sarkis   +12 more
doaj   +1 more source

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3‐Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia

Phytotherapy Research, EarlyView.
Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo, Paola Lasso, Claudia Urueña, Susana Fiorentino   +3 more
wiley   +1 more source

Novel allelic variants of blaOXA-48-like carried on IncN2 and IncC2 plasmids isolated from clinical cases in Argentina: In vivo emergence of blaOXA-567

Journal of Global Antimicrobial Resistance
: Objective: The OXA-48-like enzymes have the capacity to hydrolyse carbapenems and are members of class D β-lactamases that are primarily detected in Enterobacterales.
Juan Manuel de Mendieta, Denise De Belder, Nathalie Tijet, Barbara Ghiglione, Roberto G. Melano, Melina Rapoport, Pablo Power, Adriana Di Bella, Estefanía Biondi, Fernando Pasterán, Alejandra Corso, Sonia A. Gomez   +11 more
doaj   +1 more source

Schisandrin C Targets PPARγ to Induce Ferroptosis in Colorectal Cancer Cells and Promote M1 Macrophage Polarization

Phytotherapy Research, EarlyView.
Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei, Hong‐Ping Wen, Jian‐Bo Song, Jin‐Fang Xu, Hong‐Rui Guo   +4 more
wiley   +1 more source

Multicenter evaluation of ceftazidime-avibactam use in carbapenem-resistant Klebsiella pneumoniae bloodstream infections in OXA-48 endemic regions

Scientific Reports
Data in the literature on the use of ceftazidime-avibactam (CAZ-AVI) in carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSIs) are limited especially in OXA-48 (Oxacillinase-48) predominant regions.
Ali Mert, Okan Derin, Halis Akalın, Rıdvan Dumlu, Sibel Gündeş, Rehile Zengin, Sesin Kocagöz, Yasemin Gündoğdu, İftihar Köksal, Demet Yalçın, Cemal Üstün, Mahir Kapmaz, Levent Görenek, Kadriye Karahangil, Füsun Can, Consortium, Önder Ergönül   +16 more
doaj   +1 more source

Frequency and Benefits of Oxa- 48-Like Gene Detection in Imipenem Resistant Enterobacterales Using Phenotypic Methods

Pakistan Armed Forces Medical Journal
Objectives: To determine frequency of OXA-48 like gene in CRE and to find effectiveness of phenotypic methods for OXA-48 like gene detection. Study Design: cross-sectional study.
Saeeda Bano, Shahina Yasmin, Tariq Butt, Shazia Taj, Nehaj Tariq, Aleena Butt   +5 more
doaj   +1 more source

Frequency of OXA-48 Gene in the Enterobacteriaceae in a Tertiary Care Hospital in Lahore [PDF]

Journal of Sharif Medical & Dental College, 2019
Objective: The objective of this study was to determine the frequency of OXA-48 gene in the Enterobacteriaceae isolated from the clinical samples of hospitalized patients.
Asma Yaqoob, Namra Yunus, Sameen Bit Ali, Hirra Ghaffar, Aqsa Aslam, Sadaf Nasir   +5 more
doaj  

Sensing‐Integrated Patient‐Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics

Small, EarlyView.
The study introduces a 3D sensing‐integrated platform enabling real‐time, non‐invasive monitoring of pH dynamics in patient‐derived PDAC tumorspheres. It revealed distinct extracellular acidification patterns under FOLFIRINOX, gemcitabine, and paclitaxel, correlating with therapeutic efficacy.
Stefania Forciniti, Valentina Onesto, Anna Chiara Siciliano, Helena Iuele, Stefano D'Ugo, Norma Depalma, Cinzia Fasano, Alessandro D'Amuri, Giuseppe Gigli, Marcello G. Spampinato, Loretta L. del Mercato   +10 more
wiley   +1 more source

OXA-163, an OXA-48-Related Class D β-Lactamase with Extended Activity Toward Expanded-Spectrum Cephalosporins

, 2011
Two bla OXA-48 -like-positive isolates ( Klebsiella pneumoniae and Enterobacter cloacae ) were recovered in Argentina in 2008 as part of a large-scale survey focused on ...
Mariana Castanheira, Laurent Poirel, Amélie Carrër, Carla Parada Rodriguez, Jorgelina Smayevsky, Patrice Nordmann, Ronald N. Jones   +6 more
core   +1 more source