Results 121 to 130 of about 1,473,629 (228)

New Results From the Pre‐Pottery Neolithic Site of Al Uyaynah, Tabuk, in Northwestern Saudi Arabia

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT Al Uyaynah is a low sandstone mound on an alluvial plain, long known for its extensive surface remains of stone‐built circular and rectangular structures. Following test excavations in 2012, more detailed excavation was undertaken in 2016 within one of the largest rectangular stone structures.
Khalid Alasmari, Stephanie F. Piper, Kirsten Grothe, W. Derek Hamilton, Delphine Joly, Penny Bickle, Geoff Bailey   +6 more
wiley   +1 more source

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Enhanced meropenem activity by a microbiome derived peptide targeting oxacillinase 48 carbapenemase in carbapenem resistant Klebsiella pneumoniae isolates

Scientific Reports
Carbapenem-resistant Enterobacterales, particularly those producing oxacillinase 48 (OXA-48) carbapenemase (bla OXA−48), pose a critical global health threat, especially in the Middle East where its prevalence is remarkably high. The lack of specific OXA-
Solmaz Sadeghi, Mohammad Ali Faramarzi, Maryam Siroosi   +2 more
doaj   +1 more source

The Early Upper Palaeolithic open‐air site of Friedrichsdorf‐Seulberg, Germany, in the context of the northern central European Aurignacian

Boreas, EarlyView.
Our knowledge of the Early Upper Palaeolithic occupation in northern central Europe is very limited, and recent research at the open‐air site of Friedrichsdorf‐Seulberg in Hesse, Germany, provides important new information on the Aurignacian. The site is rather small (26.5 m2) and spatial analysis identified a central hearth with two associated ...
Tilman Böckenförde, Gabriele Russo, Neda Rahimzadeh, Felix Bittmann, Nikolitsa Nikolakopoulou, Thomas Terberger   +5 more
wiley   +1 more source

Molecular Diagnostics for WHO Priority Bacterial Pathogens: A Bibliometric Mapping of Diagnostic Platforms, Resistance Markers, and Antimicrobial Resistance Research Trends

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
This bibliometric mapping of 1746 publications (2000–2025) charts molecular diagnostics for WHO priority bacterial pathogens across platforms, targets, and resistance markers. Conventional PCR/NAAT and whole‐genome sequencing emerge as complementary core platforms, and the field evolves from targeted pathogen detection into an AMR‐centered ...
Selahattin Ünlü
wiley   +1 more source

Molecular Detection of Oxa-48 β-lactamase in Proteus spp. causing UTI

, 2019
Antibiotic resistance of pathogenic bacteria is becoming one of the most serious problems encountered by the medical community as a result of antibiotic random use. New traits of drug resistance are continuously emerging in pathogenic bacteria due to the
Mohammed Jasim Al-Shamarti
core   +1 more source

Mimicking the Ala220 Duplication of OXA-146 (an OXA-23 variant) in OXA-40 and OXA-48 Highlights Mechanistic Differences among Class D Carbapenemases.

, 2015
Background: Class D carbapenem-hydrolyzing β-lactamases (CHDLs), such as OXA-23, OXA-24/40 and OXA-48 commonly share very poor catalytic activity on expanded-spectrum cephalosporins, especially ceftazidime.
DE LUCA, FILOMENA, Pagliantini, Giorgio, DOCQUIER, JEAN DENIS, ROSSOLINI, GIAN MARIA   +3 more
core   +1 more source

Data_Sheet_1_Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness.docx

, 2019
OXA-48 is the most common carbapenemase in Enterobacterales in Germany and one of the most frequent carbapenemases worldwide. Several reports have associated blaOXA–48 with a virulent host phenotype.
Florian Wild (7616912), Axel Hamprecht (605845), Matthias Willmann (615594), Yvonne Stelzer (7616903), Felix F. Krause (7616906), Julia Kutschenreuter (7616915), Can Imirzalioglu (6205757), Ulrich Nübel (154808), Christina Brender (7616900), Aitor Gonzaga (7616918), Sara Riedel-Christ (6203687), Tsvetan Tsvetkov (7616909), Stephan Göttig (430017), Julian Sommer (7616897)   +13 more
core   +1 more source