Results 121 to 130 of about 30,220 (240)
Frequency of OXA-48 Gene in the Enterobacteriaceae in a Tertiary Care Hospital in Lahore [PDF]
Journal of Sharif Medical & Dental College, 2019 Objective: The objective of this study was to determine the frequency of OXA-48 gene in the Enterobacteriaceae isolated from the clinical samples of hospitalized patients.
Asma Yaqoob +5 more
doaj
An outbreak of carbapenem-resistant OXA-48 – producing Klebsiella pneumonia associated to duodenoscopy [PDF]
, 2015 Background Carbapenemase-producing Enterobacteriaceae (CPE) have become a major problem for healthcare systems worldwide. While the first reports from European hospitals described the introduction of CPE from endemic countries, there is now a growing ...
Gastmeier, Petra +7 more
core +2 more sources
Mapping the SHP2 Allosteric Pocket With Target‐Biased Covalent Fragments
ChemBioChem, Volume 27, Issue 8, April 2026.Target‐biased fragments combine electrophilic warheads with inhibitor pharmacophore elements. Applied to the oncogenic phosphatase SHP2, they covalently label K492 in the tunnel allosteric site, enhancing enzyme inhibition and providing a starting point for covalent SHP2 inhibitor development.
Nina‐Louisa Efrém +15 more
wiley +1 more source
First report of carbapenemase OXA-181-producing Serratia marcescens
Journal of Global Antimicrobial Resistance, 2021 Aziza Messaoudi +9 more
doaj +1 more source
Journal of Global Antimicrobial ResistanceAIM: This study aims to investigate current molecular epidemiology of carbapenemases in Enterobacterales in tertiary care hospital and comparison of phenotypic carbapenemase detection methods. Molecular tests were used as the gold standard.
Mustafa Yılmaz, Gül Durmaz
doaj +1 more source
Complete Sequence of a blaOXA-48-Harboring IncL Plasmid from an Enterobacter cloacae Clinical Isolate [PDF]
, 2015 Free PMC Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574381/We report a 63,584-bp conjugative IncL plasmid (pUR17313-1) from an Enterobacter cloacae clinical isolate, containing a blaOXA-48 gene.
Caniça, Manuela +2 more
core +1 more source
On the Evolvability of OXA-48. A comprehensive study of new functions within the β-lactamase OXA-48
, 2021 Our understanding of how antimicrobial resistance enzymes evolve to expand their substrate spectrum is limited. OXA-48, an enzyme able to catalyse the hydrolysis of β-lactam drugs, has become one of the most successfully disseminating β-lactamases. Although OXA-48 hydrolyses penicillins with high efficiency, its activity towards oxyimino cephalosporins,
openaire +1 more source
Cyclodextrin‐Amino Acid Conjugates: Synthesis and Pharmaceutical Applications
ChemistryEurope, Volume 4, Issue 4, April 2026.Cyclodextrins (CDs) can be combined with amino acids via host‐guest complexation or by covalent conjugation through various synthetic routes. The chemical modifications introduce structural versatility, multifunctionality, and biocompatibility, which are essential characteristics for designing effective, next‐generation pharmaceutical formulations ...
Andrea Cesari +2 more
wiley +1 more source
International Journal of Infectious Diseases, 2014 Objectives: To detect, characterize, and assess the genetic clonality of carbapenem-non-susceptible Enterobacteriaceae in 10 Lebanese hospitals in 2012. Methods: Selected Enterobacteriaceae isolates with reduced susceptibility to carbapenems were subject
D. Hammoudi +12 more
doaj +1 more source
NDM-1 and OXA-163 producing Klebsiella pneumoniae isolates in Cairo, Egypt, 2012 [PDF]
, 2013 Here we describe carbapenem resistance determinants in two Klebsiella pneumoniae isolates recovered from two hospitalised patients in the same intensive care unit of a cancer hospital in Cairo, Egypt.
Abdelaziz, M. O. +4 more
core +1 more source