Results 141 to 150 of about 1,473,629 (228)

The difficulties of identifying and treating Enterobacterales with OXA-48-like carbapenemases [PDF]

Clinical Microbiology and Infection, 2020
Kidd, James M., Livermore, David M., Nicolau, David P.   +2 more
openaire   +3 more sources

Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases

iMetaOmics, Volume 3, Issue 3, September 2026.
An integrative metagenomic framework combining sequence, structural, and functional inference reveals a phylogenetically diverse and structurally conserved repertoire of putative beta‐lactamases across Antarctic soil microbiomes, with predominance of class A and subclass B3 enzymes and limited but detectable associations with mobile genetic elements ...
José Coche‐Miranda, Patricio Arros, Nicolás Canales, Camilo Berríos‐Pastén, Gastón Azziz, Rosalba Lagos, Julieta Orlando, Francisco P. Chávez, Andrés E. Marcoleta   +8 more
wiley   +1 more source

Emergence of OXA-484, an OXA-48–type beta-lactamase, in Switzerland

Journal of Global Antimicrobial Resistance, 2023
Jacqueline Findlay, Juan Bosch Duran, Laurent Poirel, Patrice Nordmann   +3 more
doaj   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Nanomaterial‐Mediated Radiotherapy–Immunotherapy Combinations: Breaking Immunosuppression and Revolutionizing Cancer Treatment

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
Nanomaterials integrate radiotherapy and immunotherapy by enhancing radiosensitivity, remodeling the immunosuppressive tumor microenvironment, and promoting systemic antitumor immunity. This review summarizes the latest strategies of nanomaterial‐mediated combinations (RT, immunotherapy, IRT) and highlights future directions for overcoming clinical ...
Peijie Li, Xiangqin Wang, Sisi He, Hu Ma
wiley   +1 more source

Role of amino acid 159 in carbapenem and temocillin hydrolysis of OXA-933, a novel OXA-48 variant

International audienceOXA-48 has rapidly disseminated worldwide and become one of the most common carbapenemases in many countries with more than 45 variants reported with, in some cases, significant differences in their hydrolysis profiles.
Rima, Mariam, Creton, Elodie, Dortet, Laurent, Naas, Thierry, Oueslati, Saoussen, Cotelon, Garance, Iorga, Bogdan I., Bonnin, Rémy   +7 more
core   +1 more source

A Four‐Center Study on the Activity of Aztreonam and Aztreonam‐Avibactam Combination Against Clinical Isolates of Gram‐Negative Bacilli Producing Representatives of Ambler Class A, B, C or D β‐Lactamases

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT We aimed to investigate the activity of aztreonam and aztreonam‐avibactam combination against gram‐negative bacilli producing different types of β‐lactamases. Activity of aztreonam and aztreonam‐avibactam against 166 isolates (33 AmpC‐producing, 33 ESBL‐producing, 66 carbapenemase‐producing Enterobacterales, 34 metallo‐β‐lactamase‐producing P.
Gizem İnce Ceviz, Hasan Cenk Mirza, Aylin Üsküdar Güçlü, Özlem Öğüç Şanlı, Özlem Kurt Azap, Banu Sancak, Elvan Hortaç İştar, Ahmet Başustaoğlu   +7 more
wiley   +1 more source

The ER–Golgi Lipid Exchanger PsORP1 Is Essential for Phytophthora sojae Development and Is Blocked by Oxathiapiprolin via Its OSBP‐Related Domain (ORD)

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
PsORP1 anchors ER–Golgi MCSs to mediate PS/PI4P counter‐transport, and oxathiapiprolin targets the ORD to inhibit this lipid exchange. ABSTRACT Oxysterol‐binding protein (OSBP)‐related proteins (ORPs) are indispensable eukaryotic lipid transporters and promising targets for pharmaceutical and agrochemical exploitation.
Xiaofei Liu, Chengcheng Li, Guangda Shao, Qin Peng, Haixia Wang, Jianqiang Miao, Xili Liu   +6 more
wiley   +1 more source

Wildlife as a reservoir of OXA-48-like carbapenemase-producing Enterobacterales. [PDF]

Microbiol Spectr
Mehidi I, Sait-Gharout A, Bougaham AF, Gougam H, Iorga BI, Moulai R, Dortet L, Bonnin RA, Girlich D, Ahmim M, Oueslati S, Naas T.   +11 more
europepmc   +1 more source

OXA-48-like carbapenemases producing Enterobacteriaceaein different niches

, 2018
The emergence of carbapenem-resistant enterobacterialspecies poses a serious threat to public health worldwide.OXA-48-type carbapenem-hydrolyzing class D?- l a c tamas e s a r e widel y d i s t r i b u t e d amongEnterobacteriaceae, with significant ...
Mairi, Assia...[et al.]
core