Results 131 to 140 of about 1,076,076 (217)

carbapenems resistance mediated by OXA-48-like carbapenemases

, 2013
Les carbapénèmes constituent le traitement de dernier recours des infections associées à des germes multirésistants producteurs de -lactamases à spectre étendu.
Potron, Anaïs
core  

Zwitterionic Penicillin‐Derived Sulfone Inhibitor for Combating β‐Lactamase‐Mediated Antibiotic Resistance

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Diana Rodríguez, Emilio Lence, Juan C. Vázquez‐Ucha, Alejandro Beceiro, Concepción González‐Bello   +4 more
wiley   +1 more source

Emergence of OXA-48-producing Enterobacteriaceae in Switzerland

International Journal of Antimicrobial Agents, 2012
Potron A, Schrenzel J, Poirel L, Renzi G, Cherkaoui A, Nordmann P.   +5 more
openaire   +2 more sources

Mimicking the Ala220 Duplication of OXA-146 (an OXA-23 variant) in OXA-40 and OXA-48 Highlights Mechanistic Differences among Class D Carbapenemases.

, 2015
Background: Class D carbapenem-hydrolyzing β-lactamases (CHDLs), such as OXA-23, OXA-24/40 and OXA-48 commonly share very poor catalytic activity on expanded-spectrum cephalosporins, especially ceftazidime.
DE LUCA, FILOMENA, Pagliantini, Giorgio, DOCQUIER, JEAN DENIS, ROSSOLINI, GIAN MARIA   +3 more
core  

Synthesis of a Novel, Highly Symmetric Bis-Oxa-Bridged Compound

, 2016
A highly oxygenated, novel pentacyclic bis-oxa-bridged compound 8 was synthesized with remarkable efficiency starting from readily available tetrachloro-5,5-dimethoxyclopentadiene and 1,4-cyclohexadiene in three steps.
Jyotirmayee Dash (1616845), Faiz Ahmed Khan (599454)   +1 more
core   +1 more source

Role of amino acid 159 in carbapenem and temocillin hydrolysis of OXA-933, a novel OXA-48 variant

International audienceOXA-48 has rapidly disseminated worldwide and become one of the most common carbapenemases in many countries with more than 45 variants reported with, in some cases, significant differences in their hydrolysis profiles.
Rima, Mariam, Creton, Elodie, Dortet, Laurent, Naas, Thierry, Oueslati, Saoussen, Cotelon, Garance, Iorga, Bogdan I., Bonnin, Rémy   +7 more
core   +1 more source

Enzyme mechanism, thermostability, and structural studies of OXA-48 like carbapenemases involved in antibiotic resistance [PDF]

, 2018
Antibiotic resistance is being recognized as a world-wide crisis in modern medicine, rapidly outpacing available treatment options. The serine-beta-lactamase OXA-48 was first identified from a carbapenem- and multidrug- resistant Klebsiella pneumoniae ...
Thomassen, Ane Molden
core  

The difficulties of identifying and treating Enterobacterales with OXA-48-like carbapenemases [PDF]

Clinical Microbiology and Infection, 2020
Kidd, James M., Livermore, David M., Nicolau, David P.   +2 more
openaire   +3 more sources

OXA-48-like carbapenemases producing Enterobacteriaceaein different niches

, 2018
The emergence of carbapenem-resistant enterobacterialspecies poses a serious threat to public health worldwide.OXA-48-type carbapenem-hydrolyzing class D?- l a c tamas e s a r e widel y d i s t r i b u t e d amongEnterobacteriaceae, with significant ...
Mairi, Assia...[et al.]
core  

Culture-independent methods reveal high diversity of OXA-48-like genes in water environments

, 2017
The carbapenemase OXA-48 was identified for the first time in 2001 and is now one of the greatest concerns in terms of antibiotic resistance.
Isabel Silva, Marta Tacão, Isabel Henriques   +2 more
core   +1 more source