Results 11 to 20 of about 24,350 (217)

How To Detect NDM-1 Producers [PDF]

Journal of Clinical Microbiology, 2010
Enterobacterial isolates expressing the carbapenemase NDM-1 are emerging worldwide. Twenty-seven NDM-1-positive isolates of worldwide origin were included in this study to identify these strains as not only pathogens but also colonizers of normal flora ...
Toleman, Mark Alexander Howard, Laurent Poirel, Amélie Carrër, Timothy R. Walsh, Mark A. Toleman, Carrer, Amelie, Patrice Nordmann, Nordmann, Patrice, Poirel, Laurent, Walsh, Timothy Rutland   +9 more
core   +4 more sources

The emerging NDM carbapenemases

Trends in Microbiology, 2011
Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 ...
Laurent Poirel, Timothy R. Walsh, Livermore, David M., Walsh, Timothy R., Livermore, David M, David M. Livermore, Patrice Nordmann, Walsh, Timothy R, Nordmann, Patrice, Poirel, Laurent   +9 more
core   +6 more sources

Metallo-Beta-Lactamases: NDM

Journal of Education, Health and Sport, 2019
New Delhi, an enzyme belonging to the Metallo-beta-lactamases and Carbapenemases group, is most commonly found in Klebsiella pneumoniae and Escherichia coli. It determines these bacteria resistance to the majority of known antibiotics.
Kamil Leis, Ewelina Mazur, Paweł Szyperski, Patryk Kaczor, Michalina Kolan, Bartłomiej Wiśniewski, Magdalena Jabłońska, Aleksandra Kulczyńska, Aleksandra Baska, Jakub Kazik, Daria Bojczuk, Klaudyna Grzelakowska, Krystian Kałużny, Przemysław Gałązka   +13 more
doaj   +8 more sources

NDM-1 encoded by a pNDM-BJ01-like plasmid p3SP-NDM in clinical Enterobacter aerogenes [PDF]

Frontiers in Microbiology, 2015
A carbapenem-nonsusceptible Enterobacter aerogenes strain named 3-SP was isolated from a human case of pneumonia in a Chinese teaching hospital. NDM-1 carbapenemase is produced by a pNDM-BJ01-like conjugative plasmid designated p3SP-NDM to account for ...
Dongsheng eZhou
core   +4 more sources

INFECTIONS CAUSED BY NDM- AND NDM+KPC-PRODUCING ENTEROBACTERALES: EPIDEMIOLOGICAL PROFILE IN A UNIVERSITY HOSPITAL

The Brazilian Journal of Infectious Diseases
Introduction/Objective: The production of New Delhi Metallo-β-lactamase (NDM) by Enterobacterales has a major impact on antimicrobial therapy, particularly in multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains, significantly limiting ...
Rafael Amoroso Santos, Leonardo Neves de Andrade, Valdes Roberto Bollela, Denissani Aparecida Ferrari dos Santos Lima, Nathália de Lima Martins Abichabki, Natali Canelli Valim, Cinara Silva Feliciano, Renata Helena Candido Pocente, Lécio Rodrigues Ferreira, Nayara Maria Garcia, Amaury Quaggio Neto   +10 more
core   +2 more sources

Functional dynamics of water in New Delhi metallo-β-lactamase catalysis. [PDF]

Protein Sci
Abstract Water plays a critical role in the hydrolysis of antibiotics by New Delhi metallo‐β‐lactamases (NDMs). The reaction proceeds through a nucleophilic attack on the β‐lactam ring, followed by cleavage of the C–N bond and formation of an anionic nitrogen intermediate. This intermediate is then protonated by a water molecule diffusing from the bulk
Kandhan P, Xiong C, Palzkill T, Tao P.
europepmc   +2 more sources

The spread and acquisition of NDM-1: a multifactorial problem

Expert Review of Anti-infective Therapy, 2014
Bla NDM is a major mechanism of resistance of Gram-negative bacteria to β-lactam antibiotics including the carbapenems. bla NDM has been acquired by a large range of Gram-negative bacilli, especially by the Enterobacteriaceae and Acinetobacter spp.
Paterson, David L., Wailan, Alexander M.
core   +6 more sources

Genotypic Distribution and Antimicrobial Susceptibilities of Carbapenemase-Producing Enterobacteriaceae Isolated in Tertiary Care Hospital in South India

Journal of Pure and Applied Microbiology, 2022
Antimicrobial resistance has emerged as a major danger to contemporary medicine around the world. Carbapenems are the highest class of B-lactam drugs which are considered as the most effective and safest antibiotics available.
S. Abhishek, Shweta Sagar Naik, K.V. Leela, D. Maheswary   +3 more
doaj   +1 more source

Genomic transmission analysis of multidrug-resistant Gram-negative bacteria within a newborn unit of a Kenyan tertiary hospital: A four-month prospective colonization study

Frontiers in Cellular and Infection Microbiology, 2022
ObjectiveMultidrug-resistant organisms (MDRO), especially carbapenem-resistant organisms (CRO), represent a threat for newborns. This study investigates the colonization prevalence of these pathogens in a newborn unit at a Kenyan tertiary hospital in an ...
David Villinger, David Villinger, David Villinger, Tilman G. Schultze, Tilman G. Schultze, Tilman G. Schultze, Victor M. Musyoki, Irene Inwani, Jalemba Aluvaala, Lydia Okutoyi, Anna-Henriette Ziegler, Imke Wieters, Imke Wieters, Christoph Stephan, Christoph Stephan, Beatrice Museve, Volkhard A. J. Kempf, Volkhard A. J. Kempf, Volkhard A. J. Kempf, Moses Masika   +19 more
doaj   +1 more source

Author Correction: A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel   +9 more
doaj   +1 more source