Results 201 to 210 of about 33,486 (230)
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Carbapenemases: a problem in waiting?
Current Opinion in Microbiology, 2000Carbapenems are stable to most prevalent beta-lactamases, and chromosomal carbapenemases are restricted to Stenotrophomonas maltophilia, to a few Bacteroides fragilis, and to rare pathogens. Nevertheless, an acquired metallo-beta-lactamase called IMP-1 is beginning to emerge in Pseudomonas aeruginosa and Enterobacteriaceae isolates in Japan, and has ...
D M, Livermore, N, Woodford
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Emerging carbapenemases: a global perspective
International Journal of Antimicrobial Agents, 2010The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants.
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[Carbapenemases in enterobacteriaceae].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2011Carbapenem-hydrolyzing beta-lactamases are the most powerful mechanism of resistance to carbapenems. Carbapenemases have been reported extensively worldwide now in Enterobacteriaceae. Carbapenemases of the KPC type have been reported first from the USA in Klebsiella pneumoniae, then worldwide with a marked endemicity in Israel and Greece.
P, Nordmann, A, Carrer
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Analytical and Bioanalytical Chemistry, 2013
Laboratory identification of carbapenemase-producing clinical isolates is crucial to limit the spread of the bacteria. In this study, we shall first develop the matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) assay in automatic identification of carbapenemase producers.
Lijun, Wang +4 more
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Laboratory identification of carbapenemase-producing clinical isolates is crucial to limit the spread of the bacteria. In this study, we shall first develop the matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) assay in automatic identification of carbapenemase producers.
Lijun, Wang +4 more
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[Carbapenemases in Pseudomonas spp].
Enfermedades infecciosas y microbiologia clinica, 2010Pseudomonas aeruginosa is one of the most relevant nosocomial pathogens, as well as one of the main causes of chronic respiratory infections in patients with underlying diseases such as cystic fibrosis or chronic obstructive pulmonary disease. The high intrinsic antibiotic resistance of this pathogen, together with its extraordinary capacity for ...
Carlos, Juan Nicolau, Antonio, Oliver
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[ESBL and carbapenemases in Enterobacteriaceae].
Revue medicale suisse, 2015Carbapenemase-producing enterobacteria (CPE) spread all over the world during the last years, causing serious infections with increasing frequency. Very few new drugs active against CPE are expected to be clinically available. Studies summarized in this review show that there is yet room to improve our therapeutic approaches, in the treatment of ...
A, Cherkaoui +5 more
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Genomic Epidemiology of Carbapenemase-Producing Klebsiella Pneumoniae in China
Genomics, Proteomics and Bioinformatics, 2022Cuidan Li +2 more
exaly
Azetidinimines as carbapenemases inhibitors
2017The present application relates to novel azetidinimine of formula (I). Wherein R1-R6 are as defined in claim 1. The azetidinimine of the invention are useful as antibiotics and as inhibitors of a carbapenemases. The present invention thus further relates totheir use in antibiotic therapies and their methods of synthesis.
Dodd, Robert +4 more
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Carbapenemase producing Klebsiella pneumoniae: implication on future therapeutic strategies
Expert Review of Anti-Infective Therapy, 2022Ilias Karaiskos +2 more
exaly
Carbapenemase-producing Pseudomonas aeruginosa –an emerging challenge
Emerging Microbes and Infections, 2022David P Nicolau, Christian M Gill
exaly