Results 51 to 60 of about 4,799 (244)

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host‐Derived 12‐HEPE Against Ulcerative Colitis

Advanced Science, EarlyView.
A sulfated polysaccharide (SCP) from Cyclocarya paliurus alleviates ulcerative colitis by reshaping the gut microbiome. This remodeled microbiota orchestrates the upregulation of the host‐derived lipid 12‐HEPE, which directly inhibits the TLR4/NF‐κB pathway to suppress inflammation.
Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen, Jun Yang, Jianhua Xie   +11 more
wiley   +1 more source

Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity

Molecules, 2018
Background: Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity.
Carmela Saturnino, Fedora Grande, Stefano Aquaro, Anna Caruso, Domenico Iacopetta, Maria Grazia Bonomo, Pasquale Longo, Dominique Schols, Maria Stefania Sinicropi   +8 more
doaj   +1 more source

Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate

Nature Communications, 2020
Asymmetric functionalization of N–H bonds constitutes an important but less developed class of reactions. Here, the authors report the asymmetric direct N-propargylation of indoles and carbazoles with a lithium SPINOL phosphate as the chiral catalyst and
Yingcheng Wang, Sheng Wang, Wenyu Shan, Zhihui Shao   +3 more
doaj   +1 more source

Atroposelective Access to π‐Conjugated 1,2‐Azaborepines Enabled by Palladium‐Catalyzed Cyclization of N‐Heterobiaryls with Alkynylboronates

Advanced Science, EarlyView.
We report a palladium‐catalyzed atroposelective cyclization of N‐heterobiaryl triflates with alkynyl boronates to access seven‐membered 1,2‐BN‐bridged biaryls with high yields and excellent enantioselectivity via a cascade DyKAT, cis‐carbopalladation, and 1,2‐migration, which expands the toolbox for axially chiral π‐conjugated boron compounds and opens
Fengya He, Zhen Wang, Haoyu Guo, Shuguang Chen, Xu Zhang, Yongjia Shang, Hui Wang   +6 more
wiley   +1 more source

Trap Depth Modulation and Antenna Effect of Organic Ligands for Enhancing Rare‐Earth Long Persistent Luminescence

Advanced Science, EarlyView.
Different from the current research trends that mainly focus on optimizing a single color system, a universal organic–inorganic hybrid strategy is proposed, aiming to synergistically enhance the luminescent properties of red, green, and blue multi‐color inorganic long‐persistent phosphorescent materials by trap depth modulation and antenna effect of ...
Ting Tan, Nian Li, Bangmin Liu, Hao Wang, Xia Huang, Yuanjin Chen, Zhonghao Wang, Chaolong Yang   +7 more
wiley   +1 more source

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products.
Samar Issa, Anthony Prandina, Nicolas Bedel, Pål Rongved, Saïd Yous, Marc Le Borgne, Zouhair Bouaziz   +6 more
doaj   +1 more source

Donor Extended Blue TADF Dendrimer for High‐Performance Solution‐Processed OLEDs

Advanced Science, EarlyView.
A dendronized MR‐TADF emitter, DOBNA‐SpAc‐DCz, was designed to improve solubility, hole transport, and exciton dynamics for solution‐processed OLEDs. Incorporation of ter(tert‐butylcarbazole) dendrons decreases ΔEST and accelerates RISC, yielding short delayed lifetimes (∼2 µs).
Mahni Fatahi, Yuka Yasuda, Ryo Kondo, Hironori Kaji, Eli Zysman‐Colman   +4 more
wiley   +1 more source

Bypassing Pre‐Photoactivation in High‐Barrier Polyamide for Robust and Scalable Organic Persistent Luminescence

Advanced Science, EarlyView.
A universal paradigm resolves the trade‐off between ambient stability and barrier properties in organic persistent luminescent (OPL) polymers. By interlocking chromophores within a high‐barrier MXD6 matrix, we achieved no Pre‐photoactivation OPLs with exceptional long‐term stability in water.
Yunlong Yang, Sha Liu, Shilin Bo, Longming Jin, Baijun Tang, Zhiying Guo, Chengtao Gao, Xionggang Wang, Yuejun Liu, Qiang Zheng, Zi Liang Wu   +10 more
wiley   +1 more source

Tunable Synthesis of Multi‐Responsive NH‐Containing Helical Nanographenes With a Chiroptical Switching Function

Angewandte Chemie, EarlyView.
The Scholl reaction of 1,3,6,8‐tetrakis(oligophenyl)‐appended carbazoles afforded stable NH‐containing helical nanographenes, which showed significant redshift and reversible on/off switching of CPL upon the addition of base and acid, respectively. Furthermore, excited‐state proton transfer occurred in dimethyl sulfoxide to generate anionic species ...
Chihiro Maeda, Sayaka Michishita, Issa Yasutomo, Ryota Shimizu, Yuto Uchida, Hideyuki Otsuka, Ken Tanaka, Tadashi Ema   +7 more
wiley   +2 more sources

Base-Promoted S_NAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles

Molecules, 2019
KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has ...
Muhammad Asif Iqbal, Hina Mehmood, Jiaying Lv, Ruimao Hua   +3 more
doaj   +1 more source