Results 61 to 70 of about 16,908 (263)

Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity

Molecules, 2018
Background: Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity.
Carmela Saturnino, Fedora Grande, Stefano Aquaro, Anna Caruso, Domenico Iacopetta, Maria Grazia Bonomo, Pasquale Longo, Dominique Schols, Maria Stefania Sinicropi   +8 more
doaj   +1 more source

Direct asymmetric N-propargylation of indoles and carbazoles catalyzed by lithium SPINOL phosphate

Nature Communications, 2020
Asymmetric functionalization of N–H bonds constitutes an important but less developed class of reactions. Here, the authors report the asymmetric direct N-propargylation of indoles and carbazoles with a lithium SPINOL phosphate as the chiral catalyst and
Yingcheng Wang, Sheng Wang, Wenyu Shan, Zhihui Shao   +3 more
doaj   +1 more source

Donor‐Substituted C(sp3)‐Bridged Phosphorus‐Heterotriangulenes as Blue Thermally Activated Delayed Fluorescence Emitters

Advanced Optical Materials, EarlyView.
The newly developed regioselective strategy for the para‐functionalization of C(sp3)‐bridged phosphorus‐centered heterotriangulene delivers a series of donor‐acceptor emitters exhibiting thermally activated delayed fluorescence. The carbazole‐substituted compounds feature a unique combination of high photoluminescence quantum yields up to 75%, deep ...
Maximilian Schöner, Angelina Jocic, Siegfried Harrer, Mahni Fatahi, Jonas Maurmann, Andrea Reule, Frank Rominger, Eli Zysman‐Colman, Milan Kivala   +8 more
wiley   +1 more source

Effect of Host Anisotropy on Phosphorescent Emitter Orientation and Light Outcoupling in OLEDs

Advanced Optical Materials, EarlyView.
The orientation of the emissive transition dipole moment of a cage‐type Iridium complex can be tuned by the anisotropic alignment of the cohost material, which is expressed as the S$S$ parameter of the film. Thus, the external quantum efficiency of OLEDs can be further enhanced to reach values above 30%.
Bình‐Minh Nguyễn, Jonas Kröber, Philipp Schütz, Klaus Ruhland, Falk May, Wolfgang Brütting   +5 more
wiley   +1 more source

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products.
Samar Issa, Anthony Prandina, Nicolas Bedel, Pål Rongved, Saïd Yous, Marc Le Borgne, Zouhair Bouaziz   +6 more
doaj   +1 more source

Design and Utilization of Stable Hydrofluoroolefin‐Based Trifluoropropynyl Surrogate for Sonogashira Coupling

Advanced Synthesis &Catalysis, EarlyView.
A novel methodology for the construction of aromatic and heteroaromatic trifluoropropynyl derivatives has been developed. The new protocol is based on a tandem Sonogashira cross‐coupling reaction between a bench‐stable trifluoropropynyl carbinol reagent, generated from the commercially available and inexpensive hydrofluoroolefin‐1234yf gas, and (hetero)
Emma Bodnár, Ferenc Béke, Klára Aradi, Zoltán Novák   +3 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Base-Promoted S_NAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles

Molecules, 2019
KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has ...
Muhammad Asif Iqbal, Hina Mehmood, Jiaying Lv, Ruimao Hua   +3 more
doaj   +1 more source

Unanticipated Interfacial Redox Reaction in the NiOx Transport Layer of Perovskite Light‐Emitting Diodes

Advanced Science, EarlyView.
This study presents the unanticipated interfacial redox reaction between NiOx and perovskite, which is characterized by XPS. This redox reaction is one of the primary reasons for the bias‐induced instability of PeLEDs and is particularly suppressed by simply applying an interface layer between NiOx and perovskite.
Thi‐Hoai Do, Aswaghosh Loganathan, Yun‐Han Wu, Yaw‐Shyan Fu, Tzung‐Fang Guo   +4 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source