Results 231 to 240 of about 1,162,670 (340)

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Interactions between gut commensal bacteria and polysaccharides derived from algae and legumes: identification of metabolites produced and pathways involved. [PDF]

Curr Res Microb Sci
Biscarrat P, Pepke F, Defois-Fraysse C, Jeaidi A, Hennequet-Antier C, Rué O, Castelli F, Chollet C, Bedu-Ferrari C, Berthon JY, Chaudemanche C, Dreux-Zigha A, Langella P, Cherbuy C.   +13 more
europepmc   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Lignin-Carbohydrate Nano-Sized Structures: An Evidence of Intracellular Lignin Biosynthesis? [PDF]

Plants (Basel)
Shutskiy NA, Pokryshkin SA, Anikeenko EA, Faleva AV, Belesov AV, Pikovskoi II, Vashukova KS, Mayer LV, Kosyakov DS, Kalmykova MS, Chukhchin DG.   +10 more
europepmc   +1 more source

The Golgi Sialoglycoprotein MG160, Expressed in Pichia pastoris, Does Not Require Complex Carbohydrates and Sialic Acid for Secretion and Basic Fibroblast Growth Factor Binding

, 1997
Youjun Chen, Nicholas K. Gonatas
openalex   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Association between dietary pattern, atherogenic index of plasma, and cardiovascular disease risk factors amongst adults: A cross-sectional cohort-based study. [PDF]

PLoS One
Sayadi M, Azami P, Zibaeenezhad MJ, Motazedian N, Khademian F, Hasanzadeh M, Zibaeenejad F, Mohammadi SS, Mousavinezhad H, Daneshvar Z, Parsa N, Razeghian-Jahromi I.   +11 more
europepmc   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Interactions of Mucus Monosaccharides and the Epidermal Microbiome in Four Benthic Elasmobranchs. [PDF]

Environ Microbiol Rep
Kerr EN, Yu L, Hesse RD, Roberts CN, Bulone V, Meyer L, Edwards RA, Doane MP, Dinsdale EA.   +8 more
europepmc   +1 more source

A Metabolic-Pathway Blockade Approach to Human Longevity: Neutralizing the Effects of Carbohydrate Sugars and Isoleucine Without Dietary Restriction

Izzo, Daniel, Chat, GPT
openalex   +1 more source