Results 91 to 100 of about 4,464,693 (301)

Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme [PDF]

, 2012
The transketolase (TKT) enzyme in Mycobacterium tuberculosis represents a novel drug target for tuberculosis treatment and has low homology with the orthologous human enzyme.
Jones, T. Alwyn, Elizabeth Fullam, Cole, Stewart T., Stewart T. Cole, Jones, T Alwyn, Florence Pojer, Fullam, Elizabeth, Pojer, Florence, Bergfors, Terese, Fullam, E., Cole, Stewart T, Bergfors, T., T. Alwyn Jones, Jones, T. A., Terese Bergfors, Pojer, F., Cole, S. T., Jones, T. Alwyn,, Bergfors, Terese,   +18 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 [PDF]

, 2006
Includes bibliographical references.Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin
Chitapi, Itai
core   +1 more source

Comparative genomics reveals carbohydrate enzymatic fluctuations and herbivorous adaptations in arthropods

Computational and Structural Biotechnology Journal
Background: Arthropods represent the largest and most diverse phylum on Earth, playing a pivotal role in the biosphere. One key to their evolutionary success is their ability to feed on plant material.
Dairon Ojeda-Martinez, Isabel Diaz, M. Estrella Santamaria, Félix Ortego   +3 more
doaj   +1 more source

MACiE: a database of enzyme reaction mechanisms. [PDF]

, 2005
SUMMARY: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create
Gemma L. Holliday, Bartlett, G J, Noel M. O'Boyle, Janet M. Thornton, O'Boyle, N M, Peter Murray-Rust, John B. O. Mitchell, Holliday, G L, Almonacid, D E, Murray-Rust, P, Daniel E. Almonacid, Thornton, J M, Mitchell, John Blayney Owen, Gail J. Bartlett   +13 more
core   +2 more sources

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Improvement in carbohydrate and phlorotannin extraction from Macrocystis pyrifera using carbohydrate active enzyme from marine Alternaria sp. as pretreatment

Journal of Applied Phycology, 2017
The commercial importance of brown seaweed has been increasing over the past decade, especially due to industries interested in the extraction of phycocolloids and, more recently, of polyphenol compounds such as phlorotannins.
A. Leyton, R. Pezoa-Conte, P. Mäki-Arvela, J. Mikkola, M. Lienqueo   +4 more
semanticscholar   +1 more source

Generation of a Library of Carbohydrate-Active Enzymes for Plant Biomass Deconstruction

International Journal of Molecular Sciences, 2022
In nature, the deconstruction of plant carbohydrates is carried out by carbohydrate-active enzymes (CAZymes). A high-throughput (HTP) strategy was used to isolate and clone 1476 genes obtained from a diverse library of recombinant CAZymes covering a variety of sequence-based families, enzyme classes, and source organisms.
Cardoso, Vânia, Brás, Joana, Costa, Inês, Ferreira, Luís, Gama, Luís, Vincentelli, Renaud, Henrissat, Bernard, Fontes, Carlos   +7 more
openaire   +5 more sources

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source