Results 61 to 70 of about 134,814 (288)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Gut Microbiome and Lignocellulose Digestion in Constrictotermes cyphergaster (Termitidae: Nasutitermitinae): A Termite Incorporating Lichen into Its Diet

Diversity
Lichen-feeding termites occupy a distinctive ecological niche. This feeding behavior underscores a complex interplay between the termites’ digestive abilities and the biochemical properties of lichens, known for their resilience and production of ...
Alberto Arab, Luciana Campos Paulino, Maria Socorro Lacerda Rolim, Letícia Ramos de Menezes, Mário Herculano de Oliveira, Renato Augusto Corrêa dos Santos, João Paulo Lourenço Franco Cairo, Maria Avany Bezerra-Gusmão, Ana Maria Costa-Leonardo, Hélida Cunha, David Sillam-Dussès   +10 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The use of soybean peroxidase in amperometric biosensors [PDF]

, 2004
Traditionally Horseradish peroxidase (HRP) the archetypal class III plant peroxidase has been investigated with respect to chemical modifications, organic solvent tolerance studies, reaction kinetics, kinetics in organic solvents, immunohistochemical and
Carolan, Neil
core  

Carbohydrate utilization and metabolism is highly differentiated in Agaricus bisporus [PDF]

, 2013
Background: Agaricus bisporus is commercially grown on compost, in which the available carbon sources consist mainly of plant-derived polysaccharides that are built out of various different constituent monosaccharides.
Eastwood, Daniel C., Patyshakuliyeva, Aleksandrina, Coutinho, Pedro M., de Vries, Ronald P., Gruben, B.S., Zhou, M., Bruijn, W., de, Brink, J., van den, de Vries , Ronald P, Birgit S Gruben, Henrissat, B., Cuotinho, P.M., Henrissat, Bernard, Kabel, Mirjam, Challen, Michael P, Wiebenga, A., Nadal, Marina, Coutinho, Pedro,, Patyshakuliyeva, A., Kabel, M., Mäkelä, Miia R, Makela, Miia R., Eastwood, Daniel C, van den Brink, J., Kabel, M.A., Wouter de Bruijn, Kabel, Mirjam, Burton, Kerry S, Gruben, Birgit S, Zhou, Miaomiao, Evy Battaglia, Coutinho, Pedro, M, Ad Wiebenga, Patyshakuliyeva, A, Challen, M.P., Gruppen , Harry, Annegret Kohler, Wiebenga, Ad, Baker, Adam, Aleksandrina Patyshakuliyeva, Eastwood, D.C., Bernard Henrissat, Vries, R.P., de, Kohler, A., Mäkelä, Miia, Baker, Adam R., Adam Baker, Francis Martin, Martin, Francis, de Bruijn, Wouter, Gruben, Birgit S., Burton, K.S., Coutinho, P.M., Burton, Kerry S., Coutinho, Pedro M, Ronald P de Vries, Baker, Adam, Jurak, Edita, Martin, F., Mirjam Kabel, Pedro M Coutinho, Daniel C Eastwood, Battaglia, E., Miia R Mäkelä, Edita Jurak, Harry Gruppen, Battaglia, Evy, Makela, M.R., Michael P Challen, de Bruijn, W., Kohler, Annegret, de Vries, R.P., Gruppen, H., Kerry S Burton, Nadal, M., Gruppen, Harry, Marina Nadal, van den Brink, Joost, Jurak, E., Miaomiao Zhou, Henrissat, Bernard, Challen, Michael P., Baker, A., Joost van den Brink   +83 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

NMR-Based Structural Glycomics for High-Throughput Screening of Carbohydrate-Active Enzyme Specificity

, 2016
We report here the development of a straightforward, sensitive, and quantitative NMR-based method for high-throughput characterization of carbohydrate structure and screening of carbohydrate active enzyme (CAZyme) specificity.
Olivier Saurel (1943209), Pierre Monsan (459255), Alain Milon (412751), Magali Remaud-Siméon (1478683), Claire Moulis (474017), Jean-Charles Portais (17821), Romain Irague (474014), Gabrielle Potocki-Véronèse (1995007), Stéphane Massou (1732612)   +8 more
core   +1 more source

Comparative genomics reveals carbohydrate enzymatic fluctuations and herbivorous adaptations in arthropods

Computational and Structural Biotechnology Journal
Background: Arthropods represent the largest and most diverse phylum on Earth, playing a pivotal role in the biosphere. One key to their evolutionary success is their ability to feed on plant material.
Dairon Ojeda-Martinez, Isabel Diaz, M. Estrella Santamaria, Félix Ortego   +3 more
doaj   +1 more source

Multimodular fused acetyl–feruloyl esterases from soil and gut Bacteroidetes improve xylanase depolymerization of recalcitrant biomass

Biotechnology for Biofuels, 2020
Background Plant biomass is an abundant and renewable carbon source that is recalcitrant towards both chemical and biochemical degradation. Xylan is the second most abundant polysaccharide in biomass after cellulose, and it possesses a variety of ...
Cathleen Kmezik, Cyrielle Bonzom, Lisbeth Olsson, Scott Mazurkewich, Johan Larsbrink   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source