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Carbohydrate-active enzymes: sequences, shapes, contortions and cells
Biochemical Society Transactions, 2016The enzyme-catalysed degradation of oligo and polysaccharides is of considerable interest in many fields ranging from the fundamental–understanding the intrinsic chemical beauty–through to the applied, including diverse practical applications in medicine and biotechnology.
Gideon J, Davies, Spencer J, Williams
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Exploring the sheep rumen microbiome for carbohydrate-active enzymes
Antonie van Leeuwenhoek, 2015The rumen is a complex ecosystem enriched for microorganisms able to degrade biomass during the animal's digestion process. The recovery of new enzymes from naturally evolved biomass-degrading microbial communities is a promising strategy to overcome the inefficient enzymatic plant destruction in industrial production of biofuels. In this context, this
Lucas Dantas, Lopes +8 more
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Computational methods in the study of carbohydrates and carbohydrate-active enzymes
2018Different programs and methods were employed to superimpose protein structures, using members of four very different protein families as test subjects, and the results of these efforts were compared. Algorithms based on human identification of key amino acid residues on which to base the superpositions were nearly always more successful than programs ...
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Electrostatic studies of carbohydrate active enzymes
1995Abstract Most charged or titratable residues reside on the protein surface. Each of such residues will exhibit a titration behaviour that is dependent on the local context around the residue. As a consequence both pH, salt and docking of a ligand into the binding cavity of a protein can be expected to alter the protein electrostatics.
Antonio Baptista +5 more
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Functional proteomics for the discovery of carbohydrate-related enzyme activities
Current Opinion in Chemical Biology, 2005Carbohydrate metabolism is central to the growth and development of organisms. Thousands of genes that are believed to code for proteins that build and remodel saccharides have been uncovered by genome sequencing projects, thereby necessitating higher-throughput methods to delineate the chemical and biological functions of all these proteins.
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Carbohydrates and Carbohydrate-Active enZymes (CAZyme): An overview
2023Parmeshwar Vitthal Gavande +2 more
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Thermodynamic Characterisation of Carbohydrate-Active Enzymes
2011peer ...
Ebenhoeh, Oliver +4 more
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Carbohydrate-active enzyme annotation in microbiomes using dbCAN
Abstract CAZymes or carbohydrate-active enzymes are critically important for human gut health, lignocellulose degradation, global carbon recycling, soil health, and plant disease. We developed dbCAN as a web server in 2012 and actively maintain it for automated CAZyme annotation.Jinfang, Zheng +6 more
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The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
Nature Reviews Microbiology, 2013Abdessamad El Kaoutari +2 more
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