Results 81 to 90 of about 10,538,307 (206)

Serum NGAL to Clinically Distinguish Cholangiocarcinoma from Benign Biliary Tract Diseases

International Journal of Hepatology, 2011
Aim. To determine whether the serum level of NGAL can discriminate cholangiocarcinoma from benign biliary tract disease in patients. Methods. This study was performed according to a prospective-specimen-collection, retrospective-blinded-evaluation ...
Kawin Leelawat, Siriluck Narong, Jerasak Wannaprasert, Surang Leelawat   +3 more
doaj   +1 more source

Clinical Significance of a Cell‐Of‐Origin‐Based Classification in Pancreatic Ductal Adenocarcinoma

Cancer Science, EarlyView.
Schematic overview of a cell‐of‐origin‐based classification of pancreatic ductal adenocarcinoma (PDAC), highlighting distinct biological features and therapeutic implications of Acinar‐ and Ductal‐subtypes. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited therapeutic options and poor clinical ...
Tatsuya Kikuchi, Soichiro Ako, Hironari Kato, Hideaki Kinugasa, Masaki Uchida, Takashi Oda, Ryosuke Hirai, Akihiro Matsumi, Kazuya Miyamoto, Hiroyuki Terasawa, Yuki Fujii, Daisuke Uchida, Kazuyuki Matsumoto, Koichiro Tsutsumi, Shigeru Horiguchi, Kazuya Yasui, Tomokazu Fuji, Kosei Takagi, Hirokazu Kato, Tomoyuki Honda, Fumio Otsuka, Motoyuki Otsuka   +21 more
wiley   +1 more source

Plasma Proteomic Profiling Identifies Candidate Biomarkers for Pancreatic Ductal Adenocarcinoma. [PDF]

J Clin Lab Anal
Using DIA‐based plasma proteomics followed by ELISA validation, we identified eight circulating proteins that were significantly elevated in patients with pancreatic ductal adenocarcinoma. These proteins reflect key tumor‐associated biological processes, including exocrine dysfunction and immune remodeling, and may serve as candidates for future multi ...
Xiang L, Jin Y, Hu R, He Y, Zhang Y, Li A.   +5 more
europepmc   +2 more sources

Serum carbohydrate antigen 19-9 in pancreatic adenocarcinoma: a mini review for surgeons

, 2017
The optimal management of oncological conditions is reflected by the careful interpretation of investigations for screening, diagnosis, staging, prognostication and surveillance.
Vijayaragavan Muralidharan, Gold, G, Grace Gold, Christopher Christophi, Su Kah Goh, Goh, SK, Christophi, C, Muralidharan, V   +7 more
core   +1 more source

Carbohydrate antigen 19-9 is extremely elevated in polycystic liver disease. [PDF]

, 2009
Contains fulltext : 80299.pdf (Publisher’s version ) (Open Access)BACKGROUND/AIMS: Carbohydrate antigen 19-9 (CA19-9) is used as a biomarker to differentiate benign from malignant gastrointestinal disorders.
Waanders, Esmé, Brouwer, J.T., Fred C. G. J. Sweep, Aerts, R., van Oijen, Martijn G. H., Esmé Waanders, Drenth, J.P.H., Aerts, Raymond, Waanders, E., Drenth, Joost P. H., Nevens, Frederik, Oijen, M.G.H. van, Frederik Nevens, Johannes T. Brouwer, Raymond Aerts, Sweep, Fred C. G. J., Joost P. H. Drenth, van Keimpema, Loes, Loes Van Keimpema, Martijn G. H. Van Oijen, Keimpema, L. van, Nevens, F., Sweep, C.G.J., Brouwer, Johannes T.   +23 more
core   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source

Single-cell RNA sequencing reveals the process of CA19-9 production and dynamics of the immune microenvironment between CA19-9 (+) and CA19-9 (−) PDAC

Chinese Medical Journal
. Background:. Pancreatic ductal adenocarcinoma (PDAC) is one of the main types of malignant tumor of the digestive system, and patient prognosis is affected by difficulties in early diagnosis, poor treatment response, and a high postoperative ...
Deyu Zhang, Fang Cui, Kailian Zheng, Wanshun Li, Yue Liu, Chang Wu, Lisi Peng, Zhenghui Yang, Qianqian Chen, Chuanchao Xia, Shiyu Li, Zhendong Jin, Xiaojiang Xu, Gang Jin, Zhaoshen Li, Haojie Huang, Xiangxiang Pan   +16 more
doaj   +1 more source

Localized Gastrointestinal Light Chain (AL) Amyloidosis Under Surveillance for Five Years: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Amyloidosis, characterized by the deposition of abnormal protein fibrils in organs, is classified as systemic or localized. Amyloid light chain (AL)‐type localized amyloidosis is uncommon, particularly when confined to the gastrointestinal tract.
Shunsuke Kojimahara, Keiichi Tominaga, Akira Yamamiya, Mimari Kanazawa, Takanao Tanaka, Takeshi Sugaya, Nagaaki Katoh, Atsushi Irisawa   +7 more
wiley   +1 more source

The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice [PDF]

, 2019
Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown.
Schoepfer, Christina, Da Silva, Brandon, Creighton, Brianna, Spielman, Benjamin, Yu, Kenneth H, Gimotty, Phyllis A, Engle, Dannielle D, Park, Youngkyu, Oni, Tobiloba E, Tiriac, Hervé, Hruban, Ralph H, Tuveson, David A, Afinowicz, Lauren, Whalen, Sean, Rivera, Keith D, Wright, Kevin, Alagesan, Brinda, Lee, Eun Jung, Goggins, Michael G, Hollingsworth, Michael A, Pappin, Darryl J, Grützmann, Robert, Pommier, Arnaud, Aust, Daniela, Lucito, Matthew S, Yao, Melissa A, Pilarsky, Christian, Pollard, Katherine S   +27 more
core   +2 more sources

Optimal Stenting Strategy During Chemotherapy: Impact of Time to First Reintervention on Survival in Malignant Hilar Biliary Obstruction

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives Advances in chemotherapy have increased survival in biliary tract cancer patients, and reports of the effectiveness of neoadjuvant therapy are emerging. Accordingly, developing optimal drainage strategies under chemotherapy is important.
Katsuhiko Sato, Minoru Shigekawa, Teppei Yoshioka, Kazuma Daiku, Syuhei Yamamoto, Yu Sato, Takahiro Kodama, Hayato Hikita, Tetsuo Takehara   +8 more
wiley   +1 more source