Results 111 to 120 of about 21,815 (192)

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

open access: yesAdvanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni   +15 more
wiley   +1 more source

METABOLISM OF CARBOHYDRATES BY PSEUDOMONAS SACCHAROPHILA I [PDF]

open access: bronze, 1956
Michael Doudoroff   +3 more
openalex   +1 more source

Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma

open access: yesAdvanced Science, EarlyView.
To address the challenge of postoperative recurrence, Combo Gel, a peptide‐based hydrogel that integrates glutamine metabolism modulation with chemodynamic therapy (CDT) is engineered. This innovative system, containing CB‐839 and copper peptide nanoparticles (Cu‐His NPs), enhances CDT's efficacy and promotes immunogenic cell death, thereby ...
Yiran Guo   +9 more
wiley   +1 more source

Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

open access: yesAdvanced Science, EarlyView.
A potent HDAC11‐specific inhibitor, B6, is identified using substrate‐mimic and bioisosteric replacement strategies. B6 demonstrates high oral bioavailability, extensive liver distribution, and a favorable safety profile. B6 effectively alleviates metabolic dysfunction‐associated steatotic liver disease by increasing the expression of LKB1 and ...
Feng Zhang   +10 more
wiley   +1 more source

STUDIES IN CARBOHYDRATE METABOLISM

open access: hybrid, 1925
Christen Lundsgaard, Svend Aage Holbøll
openalex   +2 more sources

EFFECTS OF METABOLIC AND HAEMOSTATIC PARAMETERS ON DIABETIC ANGIOPATHY PROGRESSION

open access: yesРоссийский кардиологический журнал, 2011
The parameters of carbohydrate, protein, lipid metabolism and haemostasis were analysed in patients with Type 1 and 2 diabetes mellitus (DM-1, DM-2), who demonstrated the progression of micro- and macroangiopathy over the five-year follow-up period ...
G. G. Petrik, S. A. Pavlishchuk
doaj  

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

open access: yesAdvanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang   +5 more
wiley   +1 more source

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