Results 61 to 70 of about 1,712,313 (354)

Maternal Lipid Metabolism Directs Fetal Liver Programming following Nutrient Stress

Cell Reports, 2019
Summary: The extreme metabolic demands of pregnancy require coordinated metabolic adaptations between mother and fetus to balance fetal growth and maternal health with nutrient availability.
Caitlyn E. Bowman, Ebru S. Selen Alpergin, Kyle Cavagnini, Danielle M. Smith, Susanna Scafidi, Michael J. Wolfgang   +5 more
doaj   +1 more source

A Validated Model to Predict Severe Weight Loss in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Severe weight loss in amyotrophic lateral sclerosis (ALS) is common, multifactorial, and associated with shortened survival. Using longitudinal weight data from over 6000 patients with ALS across three cohorts, we built an accelerated failure time model to predict the risk of future severe (≥ 10%) weight loss using five single‐timepoint ...
David G. Lester, Kevin Talbot, Martin R. Turner, Alexander G. Thompson, the Pooled Resource Open‐Access ALS Clinical Trials Consortium   +4 more
wiley   +1 more source

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

Quantitative analysis of the grain amyloplast proteome reveals differences in metabolism between two wheat cultivars at two stages of grain development

BMC Genomics, 2018
Background Wheat (Triticum aestivum L.) is one of the world’s most important grain crops. The amyloplast, a specialized organelle, is the major site for starch synthesis and storage in wheat grain.
Dongyun Ma, Xin Huang, Junfeng Hou, Ying Ma, Qiaoxia Han, Gege Hou, Chenyang Wang, Tiancai Guo   +7 more
doaj   +1 more source

DRAM for distilling microbial metabolism to automate the curation of microbiome function

bioRxiv, 2020
Microbial and viral communities transform the chemistry of Earth’s ecosystems, yet the specific reactions catalyzed by these biological engines are hard to decode due to the absence of a scalable, metabolically resolved, annotation software.
Michael Shaffer, M. Borton, Bridget B. McGivern, A. Zayed, S. L. La Rosa, L. Solden, Pengfei Liu, Adrienne B. Narrowe, J. Rodríguez-Ramos, B. Bolduc, M. C. Gazitúa, R. Daly, Garrett Smith, D. Vik, Phil B. Pope, Matthew B. Sullivan, S. Roux, K. Wrighton   +17 more
semanticscholar   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Percutaneous coronary intervention for patients with type 2 diabetes mellitus: risks and novel way to manage

Сахарный диабет, 2019
The article is a literature review devoted to issues of planned percutaneous coronary intervention for patients with type 2 diabetes mellitus. Pathogenetic base of poor prognosis and new ways to pharmacological risk correction are described.
Anastasia M. Kochergina, Alina A. Khorlampenko   +1 more
doaj   +1 more source

dbCAN2: a meta server for automated carbohydrate-active enzyme annotation

Nucleic Acids Res., 2018
Complex carbohydrates of plants are the main food sources of animals and microbes, and serve as promising renewable feedstock for biofuel and biomaterial production.
Han Zhang, Tanner Yohe, Le Huang, Sarah Entwistle, Peizhi Wu, Zhenglu Yang, P. Busk, Ying Xu, Yanbin Yin   +8 more
semanticscholar   +1 more source

Key Trends and Insights in Smart Polymeric Skin Wearable Patches

Advanced Engineering Materials, EarlyView.
Intelligent polymers, which respond to various physical and biological stimuli, are explored for the development of skin wearable patches in biomedical applications. Smart polymers, also known as intelligent or stimuli‐responsive polymers, play a crucial role in the development of advanced wearable patches due to their versatility and softness.
Sergio J. Peñas‐Núñez, Rajat Rai, Miryam Criado‐Gonzalez   +2 more
wiley   +1 more source

Effects of heat stress on carbohydrate and lipid metabolism in growing pigs

Physiological Reports, 2015
Heat stress (HS) jeopardizes human and animal health and reduces animal agriculture productivity; however, its pathophysiology is not well understood. Study objectives were to evaluate the direct effects of HS on carbohydrate and lipid metabolism. Female
M. Victoria Sanz Fernandez, Jay S. Johnson, M. Abuajamieh, S. Stoakes, J. Seibert, Lindsay Cox, S. Kahl, T. Elsasser, J. Ross, S. Clay Isom, R. Rhoads, L. Baumgard   +11 more
semanticscholar   +1 more source