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Carbohydrate-functionalized oligothiophenes for concanavalin A recognition

Chem. Commun., 2011
Versatile synthesis of fluorescent, carbohydrate-functionalized oligothiophene hybrids via Sonogashira-type cross coupling reactions is reported. The mannose derivatives reveal specific binding with the model lectin from Canavalia enisformis (Concanavalin A).
Sylvia, Schmid   +2 more
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Recognition of Carbohydrates

2013
The aim of this chapter is to provide a small guide to the different techniques used to evaluate molecular recognition of carbohydrates by artificial receptors through a selection of the most recent and innovative papers published in the field. Although an extensive amount of work has been reported on the use of reversible covalent-bond formation in ...
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Carbohydrates and antigen recognition by T cells

Glycobiology, 1997
T Lymphocytes (T cells) recognize short antigenic peptides bound to either MHC I or II molecules, in contrast to antibodies which can bind to native antigen. The mechanism by which antigens are processed into peptides, and the nature of the interactions of antigenic peptides with MHC molecules and with the T cell receptor have now been defined in some ...
F R, Carbone, P A, Gleeson
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Recognition of Anionic Carbohydrates by an Artificial Receptor in Water

Organic Letters, 2005
A tris-cationic artificial receptor 1 efficiently binds anionic carbohydrates even in aqueous solution as shown by NMR and UV titration experiments. Complex formation involves both ion pair formation and H-bonds to the sugar, explaining the preference for saccharides compared to simple anions and the observed selectivities among different sugars ...
Schmuck, Carsten, Schwegmann, Michael
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The Structural Basis for Carbohydrate Recognition By Lectins

2001
1. Different carbohydrate-specific proteins, such as lectins, may combine with the same monosaccharide or oligosaccharide by different H-bonding and hydrophobic side chains. 2. Homologous proteins with distinct specificities may bind different monosaccharides (e.g., for glucose and galactose that differ in the configuration of a single hydroxyl) by the
N, Sharon, H, Lis
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Carbohydrate Recognition Systems in Innate Immunity

1998
Carbohydrate-protein interactions have emerged as important recognition systems in the orchestration of mechanisms of innate immunity1. Unlike the usual situation of receptor-ligand pairs2, a picture is emerging of recognition systems that operate as triads: receptors, ligands and carriers.
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Carbohydrate-Carbohydrate Recognition between LewisX Glycoconjugates.

Angewandte Chemie (International ed. in English)
The strong dependence of the NOE on the molecular mobility rendered the weak bond of a homotypical carbohydrate-carbohydrate recognition detectable in a simplified model system. The membrane-bound LeX trisaccharide 1, which functions as a receptor, transiently binds the dissolved LeX trisaccharide 2, thus slowing down its rotational diffusion.
Armin, Geyer   +2 more
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Overcoming Degeneracy in Carbohydrate Recognition

Angewandte Chemie International Edition, 2003
Amit, Basu, Daniel, Kahne
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Carbohydrate recognition molecules on lymphocytes

Biochemical Society Transactions, 1992
C R, Parish   +3 more
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