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Hybrid method sequences carbohydrates
C&EN Global Enterprise, 2017Methods for routine sequencing of carbohydrates lag behind those for sequencing nucleic acids and proteins. The lack of such methods makes fully characterizing carbohydrates difficult. Sequencing a carbohydrate is a challenge because many of the sugar building blocks are isomers of one another, making it hard to distinguish between them, and the ...
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LINUCS: LInear Notation for Unique description of Carbohydrate Sequences
Carbohydrate Research, 2001The use of proteomics databases has become indispensable for daily work of molecular biologists, but this situation has not yet been achieved for carbohydrate applications. One obvious reason is that existing data collections are only rarely annotated and no cross-linking to other resources exists.
A, Bohne-Lang +3 more
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Carbohydrate sequences detected by murine monoclonal antibodies
Chemistry and Physics of Lipids, 1986The carbohydrate sequences of cell surface glycolipids change during differentiation and oncogenic transformation. To detect these structural changes, murine monoclonal antibodies have been produced in many different laboratories. Some of these antibodies are used to distinguish various cell types such as normal and transformed cells, while others are ...
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Sequence-Specific Peptide−Carbohydrate Interactions in an Asparagine-Linked Glycopeptide
The Journal of Organic Chemistry, 1996Asparagine glycosylation (N-glycosylation) of the AsnXaa-Ser/Thr sequence is a cotranslational process that can affect protein structure and function.1,2 Little is known, however, about glycosylation’s influence on the structure of flexible N-glycopeptides.3-7 Fluorescence studies show that N-glycosylation can alter peptide backbone conformation.6 ...
Kwun-Chi, Lee +2 more
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CabosDB: Carbohydrate Sequencing Database
2009High-throughput methods for sequencing biomolecules such as DNA, RNA and proteins, and for profiling their patterns of expression have accelerated genome-wide analyses in living organisms. Further, they have enabled molecular biologists and biochemists to investigate biological functions and disorders, the so-called -omics studies. Glycomics, which has
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Human Urinary Kallikrein: Amino Acid Sequence and Carbohydrate Attachment Sites
1989The amino acid sequence of human urinary kallikrein was determined by protein-chemical methods. The peptide chain contains 238 amino acid residues. Ten half-cystine residues form five disulfide bridges. Six carbohydrate side chains could be identified, three of them are N-glycosidically linked to asparagine which is present in the acceptor sequon Asn ...
J, Kellermann +3 more
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Sequencing methods for carbohydrates and their biological applications
Trends in Biotechnology, 1989Abstract The diversity of oligosaccharide structures may confer the specificity inherent in many molecular and cellular interactions. Scientists from numerous disciplines are faced with the challenge of determining their sequence and deciphering their function.
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Glycoprofiling by DNA Sequencer-Aided Fluorophore-Assisted Carbohydrate Electrophoresis
2007In recent years, the importance of glycosylation has been realized. Carbohydrates not only serve as decoration for proteins and lipids but also form an integral part of the glycoconjugate, adding to its functional and structural properties. The specific type of glycosylation may change with altering physiological conditions, such as disease.
Wouter Laroy, Roland Contreras
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Sequence-Based Prediction of Protein–Carbohydrate Binding Sites Using Support Vector Machines
Journal of Chemical Information and Modeling, 2016Carbohydrate-binding proteins play significant roles in many diseases including cancer. Here, we established a machine-learning-based method (called sequence-based prediction of residue-level interaction sites of carbohydrates, SPRINT-CBH) to predict carbohydrate-binding sites in proteins using support vector machines (SVMs).
Taherzadeh, Ghazaleh +3 more
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The double‐DANTE sequence applied to NMR of complex carbohydrates
Magnetic Resonance in Chemistry, 1991AbstractThe double‐DANTE sequence was implemented in 1D TOCSY and NOESY experiments to overcome some typical problems in the NMR of carbohydrates. In the 1D TOCSY experiment the double‐DANTE sequence serves to invert simultaneously two resonances belonging to the same scalar‐coupled spin system, thereby substantially increasing the sensitivity of the ...
Leszek Poppe, Herman van Halbeek
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