Results 261 to 270 of about 6,617,754 (307)

Carbon‐11 radiolabeling of an oligopeptide containing tryptophan hydrochloride via a Pictet‐Spengler reaction using carbon‐11 formaldehyde

Journal of Peptide Science, 2013
A procedure for the synthesis of a11C‐labeled oligopeptide containing [1‐11C]1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylic acid ([1‐11C]Tpi) from the corresponding Trp•HCl‐containing peptides has been developed involving a Pictet‐Spengler reaction with [11C]formaldehyde.
Masayuki, Hanyu, Yuuki, Takada, Hiroki, Hashimoto, Kazunori, Kawamura, Ming-Rong, Zhang, Toshimitsu, Fukumura   +5 more
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The preparation of a carbon-11 labelled neurohormone—[11C]melatonin

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1987
Melatonin, a hormone of the pineal gland, has been labelled with the positron-emitting radionuclide, carbon-11 (t1/2 = 20.4 min), for study in vivo by positron emission tomography. Thus a novel labelling agent, [11C]acetyl chloride, was prepared by the carbonation of methylmagnesium bromide with cyclotron-produced [11C]carbon dioxide followed by ...
D, Le Bars, S K, Luthra, V W, Pike, C L, Duc   +3 more
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Carbon-11 acetate as a tracer of myocardial oxygen consumption

European Journal of Nuclear Medicine, 2001
Estimation of myocardial oxygen consumption (MVO2) and myocardial blood flow (MBF) is important for the understanding of various (patho)physiological mechanisms and diseases. Clearance rates of carbon-11 labelled acetate, determined with positron emission tomography, allow estimation of MVO2 on a segmental level and non-invasively. In addition, MBF can
L J, Klein, F C, Visser, P, Knaapen, J H, Peters, G J, Teule, C A, Visser, A A, Lammertsma   +6 more
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Studies to label alfentanil with carbon-11

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1992
Methodology applicable to the synthesis of no-carrier-added [O-methyl-11C]alfentanil was developed. The sequence consisted of [11C]methylation and propionylation of N-aryl-4-(hydroxymethyl)-4-(N-anilino)-piperidines1a and 1c, followed by the chemoselective hydrolysis of bulk byproducts to facilitate isolation of the NCA carbon-11-labeled product by ...
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Tumor detection with carbon-11-labelled amino acids

European Journal of Nuclear Medicine, 1984
A comparative study of tumor detection with ten 11C-labeled amino acids including four newly synthesized amino acids was carried out to find the most valuable 11C-labeled amino acid for the diagnosis of cancer. 11C-L-methionine showed the highest uptake by the experimental rat hepatoma AH109A (2.7% administered dose/g at 20 min, tumor to blood ratio ...
Kazuo Kubota, Kenji Yamada, Hiroshi Fukada, Satoshi Endo, Masatoshi Ito, Yoshinao Abe, Tatsuo Yamaguchi, Takehiko Fujiwara, Tachio Sato, Kengo Ito, Seiro Yoshioka, Jun Hatazawa, Taiju Matsuzawa, Ren Iwata, Tatsuo Ido   +14 more
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Automated preparation of carbon-11 ethanol and carbon-11 butanol for human studies using positron emission tomography

Journal of Radioanalytical and Nuclear Chemistry, 1986
An automated continuous flow process has been developed for the synthesis of11C-ethanol and11C-butanol. These alcohols were synthesized via the same route. The reaction of11CO2 with methylmagnesium bromide or with n-propylmagnesium chloride, followed by a lithium aluminum hydride reduction and hydrolysis produced respectively11C-ethanol and11C-butanol.
G. Del Fiore, J. M. Peters, L. Quaglia, F. Boudjelida, M. C. Pardon, J. L. Piette, R. Cantineau, Ch. De Landsheere, P. Rigo   +8 more
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Carbon-11 Radiopharmaceuticals - Radiopharmacy Aspects

1992
Examples of the routine production of some 11C-labelled PET radiopharmaceuticals which have been set up for patient application are discussed. This includes recommendations and general guidelines for safety and procedures for the a) preparation of the radionuclide and the primary precursors b) synthesis of some secondary precursors c) synthesis ...
C. Halldin, S-O. Nilsson
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Feasibility of planar myocardial carbon 11-acetate imaging

Journal of Nuclear Cardiology, 2000
Myocardial oxygen consumption can be determined by using carbon 11-acetate (11C-acetate) and positron emission tomography (PET). The aim of this study was to validate planar 11C-acetate scintigraphy in healthy individuals by relating the myocardial clearance rate of dynamic 11C-acetate scintigraphy with the rate-pressure product, which is used as a ...
L J, Klein, F C, Visser, S A, Nurmohamed, A, Vink, J H, Peters, P, Knaapen, P S, Kruijer, J D, Herscheid, G J, Teule, C A, Visser   +9 more
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Imaging Myocardium Enzymatic Pathways with Carbon-11 Radiotracers

2004
Publisher Summary This chapter elaborates the imaging of myocardium enzymatic pathways with carbon-11 radiotracers. Under normal conditions, the heart utilizes a variety of metabolic pathways, such as the oxidation of carbohydrates, fatty acids, lactate, and pyruvate, to meet the high-energy demands of contraction and maintenance of cellular function.
Carmen S, Dence, Pilar, Herrero, Sally W, Schwarz, Robert H, Mach, Robert J, Gropler, Michael J, Welch   +5 more
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Fixation of Carbon-11 in the Cells of Proton-irradiated Blood

Nature, 1965
WHEN considering the possibility of marking cell populations with a short-lived, positron-emitting nuclide, carbon-11 (11C, T½ = 20.5 min) appears to be suitable because, when produced through nuclear reactions in proton-irradiation of cells, it may be expected to react chemically with the intracellular material in the same way as it does with simpler ...
B, Larsson, S, Graffman, B, Jung
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