Results 251 to 260 of about 1,004,004 (297)

Automated preparation of carbon-11 ethanol and carbon-11 butanol for human studies using positron emission tomography

Journal of Radioanalytical and Nuclear Chemistry, 1986
An automated continuous flow process has been developed for the synthesis of11C-ethanol and11C-butanol. These alcohols were synthesized via the same route. The reaction of11CO2 with methylmagnesium bromide or with n-propylmagnesium chloride, followed by a lithium aluminum hydride reduction and hydrolysis produced respectively11C-ethanol and11C-butanol.
G. Del Fiore, J. M. Peters, L. Quaglia, F. Boudjelida, M. C. Pardon, J. L. Piette, R. Cantineau, Ch. De Landsheere, P. Rigo   +8 more
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Imaging Myocardium Enzymatic Pathways with Carbon-11 Radiotracers

2004
Publisher Summary This chapter elaborates the imaging of myocardium enzymatic pathways with carbon-11 radiotracers. Under normal conditions, the heart utilizes a variety of metabolic pathways, such as the oxidation of carbohydrates, fatty acids, lactate, and pyruvate, to meet the high-energy demands of contraction and maintenance of cellular function.
Carmen S, Dence, Pilar, Herrero, Sally W, Schwarz, Robert H, Mach, Robert J, Gropler, Michael J, Welch   +5 more
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Estimation of carbon‐11 in the atmosphere

International Journal of Environmental Studies, 1988
The production of 20 minute C‐11 by interactions of cosmic ray primary and secondary particles with atmospheric nitrogen and oxygen is calculated. We estimate unmeasured C‐11 to be the fifth most active cosmogenic radionuclide in the lower atmosphere with a disintegration rate of 0.014 dpm/m3. Nevertheless, its actual measurement will not prove an easy
Michael J. Tobin, Paul J. Karol
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Carbon-11/carbon-14 kinetic isotope effects

Journal of the American Chemical Society, 1987
Kinetic isotope effect (KIE) measurements employing the isotopes of hydrogen as well as many heavy elements have frequently been utilized in the elucidation of organic and enzymatic reactions mechanisms. In this paper the authors report a method for the determination of /sup 11/C//sup 14/C KIE.
B. Svante Axelsson, Bengt Laangstroem, Olle Matsson   +2 more
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Synthesis of carbon‐11 labelled (R)‐carnitine

Journal of Labelled Compounds and Radiopharmaceuticals, 1991
AbstractA route to 11C‐labelled (R)‐carnitine (1), based on the methylation of the dimethyl derivative (2) is described. Furthermore, a five‐step synthesis for the enantiomerically pure precursor (2) is outlined.
M. Holschbach, W. Hamkens, W. Roden, L. E. Feinendegen   +3 more
openaire   +1 more source

Radiation dose estimates for carbon-11-labelled PET tracers

Nuclear Medicine and Biology, 2012
Carbon-11-labelled positron emission tomography (PET) tracers commonly used in biomedical research expose subjects to ionising radiation. Dosimetry is the measurement of radiation dose, but also commonly refers to the estimation of health risk associated with ionising radiation.
van der Aart, Jasper, Hallett, William A, Rabiner, Eugenii A, Passchier, Jan, Comley, Robert A   +4 more
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Studies to label alfentanil with carbon-11

International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1992
Methodology applicable to the synthesis of no-carrier-added [O-methyl-11C]alfentanil was developed. The sequence consisted of [11C]methylation and propionylation of N-aryl-4-(hydroxymethyl)-4-(N-anilino)-piperidines1a and 1c, followed by the chemoselective hydrolysis of bulk byproducts to facilitate isolation of the NCA carbon-11-labeled product by ...
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Carbon-11 labeled radioligands for imaging brain cannabinoid receptors

Nuclear Medicine and Biology, 2002
Two radioligands, [(11)C] SR149080 and its morpholino analog [(11)C] SR149568, were synthesized by reaction of the respective phenolic precursors with [(11)C] methyl iodide. Both radioligands had appropriate regional brain distribution for cannabinoid receptors in mice with peak target to non-target ratios of 2.2 for [(11)C] SR149080 and 1.6 for [(11)C]
William B, Mathews, Ursula, Scheffel, Paige A, Rauseo, Hayden T, Ravert, Richard A, Frank, George J, Ellames, John M, Herbert, Francis, Barth, Murielle, Rinaldi-Carmona, Robert F, Dannals   +9 more
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Carbon-11-methionine positron emission tomography imaging of chordoma

Skeletal Radiology, 2004
Chordoma is a rare malignant bone tumor that arises from notochord remnants. This is the first trial to investigate the utility of (11)C-methionine (MET) positron emission tomography (PET) in the imaging of chordoma before and after carbon-ion radiotherapy (CIRT).Fifteen patients with chordoma were investigated with MET-PET before and after CIRT and ...
Hong, Zhang, Kyosan, Yoshikawa, Katsumi, Tamura, Kenji, Sagou, Mei, Tian, Tetsuya, Suhara, Susumu, Kandatsu, Kazutoshi, Suzuki, Shuji, Tanada, Hirohiko, Tsujii   +9 more
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Transverse Section Imaging with Carbon-11 Labeled Carbon Monoxide

Journal of Computer Assisted Tomography, 1978
The inhalation of small quantities of carbon-11 labeled carbon monoxide results in a useful red cell label to identify vascular structures in the body and quantitate red cell concentration in tissues. Transverse section images are obtained using PC-II, the Massachusetts General Hospital (MGH) Positron Camera.
G L, Brownell, S, Cochavi
openaire   +2 more sources