Results 51 to 60 of about 6,617,754 (307)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Synthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation

Molecules, 2017
Positron emission tomography is an imaging technique with applications in clinical settings as well as in basic research for the study of biological processes.
Sara Roslin, Peter Brandt, Patrik Nordeman, Mats Larhed, Luke R. Odell, Jonas Eriksson   +5 more
doaj   +1 more source

Degradation changes stable carbon isotope depth profiles in palsa peatlands [PDF]

, 2014
Palsa peatlands are a significant carbon pool in the global carbon cycle and are projected to change by global warming due to accelerated permafrost thaw. Our aim was to use stable carbon isotopes as indicators of palsa degradation.
Leifeld, J., C. Alewell, J. P. Krüger, Alewell, C., Krueger, J. P., J. Leifeld   +5 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Effect of Different Pore-Forming Additives on the Formation of PVDF Microporous Membranes for Bucky-Gel Actuator

Eurasian Chemico-Technological Journal, 2020
The microporous polyvinylidene fluoride (PVDF) membranes were prepared by the solvent evaporation method using 50 wt.% of different pore-forming additives: poly(1-ethyl-3-vinylimidazolium tetrafluoroborate) (PIL-BF4), polyethylene glycol 3000 (PEG-3K ...
O. S. Morozov, S. S. Shachneva, B. A. Bulgakov, A. V. Babkin, A. V. Kepman   +4 more
doaj   +1 more source

Decreased carbon-11-flumazenil binding in early Alzheimer’s disease [PDF]

Brain, 2012
Neuronal loss in Alzheimer's disease, a better correlate of cognitive impairment than amyloid deposition, is currently gauged by the degree of regional atrophy. However, functional markers, such as GABA(A) receptor density, a marker of neuronal integrity, could be more sensitive.
Pascual, Belen, Prieto, Elena, Arbizu, Javier, Marti-Climent, Josep M., Peñuelas, Ivan, Quincoces, Gemma, Zarauza, Rosina, Pappatà, Sabina, Masdeu, Joseph C.   +8 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Data on compressibility of NBR samples with various cross-linking degree and zinc oxide content immersed in gasoline and oil

Data in Brief, 2020
NBR materials are widely used in oil refining, automotive industry and aviation due to the high tensile strength and elasticity, resistance to dilute acids.
Ilya Karzov, Anton Nashchokin, Nikolay Tikhonov, Denis Kalugin, Artem Malakho   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling

Molecules, 2018
Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation.
Michelle Y. Cortes-Salva, Stal Shrestha, Prachi Singh, Cheryl L. Morse, Kimberly J. Jenko, Jose A. Montero Santamaria, Sami S. Zoghbi, Robert B. Innis, Victor W. Pike   +8 more
doaj   +1 more source